Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ryu Okumura"'
Autor:
Ryu Okumura, Kiyoshi Takeda
Publikováno v:
Inflammation and Regeneration, Vol 38, Iss 1, Pp 1-8 (2018)
Abstract Background The intestine is inhabited by a tremendous number of microorganisms, which provide many benefits to nutrition, metabolism and immunity. Mucosal barriers by intestinal epithelial cells make it possible to maintain the symbiotic rel
Externí odkaz:
https://doaj.org/article/f5f107cc41d148f4a9108b2993c7b6c1
Publikováno v:
Inflammation and Regeneration, Vol 37, Iss 1, Pp 1-9 (2017)
Abstract Background We previously reported that the mouse Ly6/Plaur domain containing 8 (mLypd8), a GPI-anchored protein highly and selectively expressed on colonic epithelia, contributes to segregation of intestinal microbiota and intestinal epithel
Externí odkaz:
https://doaj.org/article/20223a6d26024c5d8a0bfc143c65e18d
Autor:
Kayo Ikeda, Makoto Kinoshita, Hisako Kayama, Shushi Nagamori, Pornparn Kongpracha, Eiji Umemoto, Ryu Okumura, Takashi Kurakawa, Mari Murakami, Norihisa Mikami, Yasunori Shintani, Satoko Ueno, Ayatoshi Andou, Morihiro Ito, Hideki Tsumura, Koji Yasutomo, Keiichi Ozono, Seiji Takashima, Shimon Sakaguchi, Yoshikatsu Kanai, Kiyoshi Takeda
Publikováno v:
Cell Reports, Vol 21, Iss 7, Pp 1824-1838 (2017)
Summary: Foxp3+ regulatory T (Treg) cells, which suppress immune responses, are highly proliferative in vivo. However, it remains unclear how the active replication of Treg cells is maintained in vivo. Here, we show that branched-chain amino acids (B
Externí odkaz:
https://doaj.org/article/2f6375032a6040699398008e3fa35d9a
Autor:
Yoki Furuta, Shih-Han Tsai, Makoto Kinoshita, Kosuke Fujimoto, Ryu Okumura, Eiji Umemoto, Yosuke Kurashima, Hiroshi Kiyono, Hisako Kayama, Kiyoshi Takeda
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172509 (2017)
Extracellular adenosine 5'-triphosphate (ATP) performs multiple functions including activation and induction of apoptosis of many cell types. The ATP-hydrolyzing ectoenzyme ecto-nucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP3) regulates ATP-de
Externí odkaz:
https://doaj.org/article/47dd530950804d9591d889c31d2717dc
Autor:
Seong Gyu Jeon, Hisako Kayama, Yoshiyasu Ueda, Takuya Takahashi, Takashi Asahara, Hirokazu Tsuji, Noriko M Tsuji, Hiroshi Kiyono, Ji Su Ma, Takashi Kusu, Ryu Okumura, Hiromitsu Hara, Hiroki Yoshida, Masahiro Yamamoto, Koji Nomoto, Kiyoshi Takeda
Publikováno v:
PLoS Pathogens, Vol 8, Iss 5, p e1002714 (2012)
Specific intestinal microbiota has been shown to induce Foxp3(+) regulatory T cell development. However, it remains unclear how development of another regulatory T cell subset, Tr1 cells, is regulated in the intestine. Here, we analyzed the role of t
Externí odkaz:
https://doaj.org/article/a42b9d4caefb44839522cef5494673c1
Autor:
Takahisa Matsuzaki, Daigo Terutsuki, Shoma Sato, Kohei Ikarashi, Kohei Sato, Hidefumi Mitsuno, Ryu Okumura, Yudai Yoshimura, Shigeyoshi Usami, Yusuke Mori, Mai Fujii, Shota Takemi, Seiichiro Nakabayashi, Hiroshi Y. Yoshikawa, Ryohei Kanzaki
Publikováno v:
The journal of physical chemistry letters. 13(40)
Cell-coupled field-effect transistor (FET) biosensors have attracted considerable attention because of their high sensitivity to biomolecules. The use of insect cells (Sf21) as a core sensor element is advantageous due to their stable adhesion to sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f27e2b93ce8afdb9737c527072f17dd
https://pubmed.ncbi.nlm.nih.gov/36201238
https://pubmed.ncbi.nlm.nih.gov/36201238
Autor:
Takuro Nii, Yuichi Maeda, Daisuke Motooka, Mariko Naito, Yuki Matsumoto, Takao Ogawa, Eri Oguro-Igashira, Toshihiro Kishikawa, Makoto Yamashita, Satoshi Koizumi, Takashi Kurakawa, Ryu Okumura, Hisako Kayama, Mari Murakami, Taiki Sakaguchi, Bhabatosh Das, Shota Nakamura, Yukinori Okada, Atsushi Kumanogoh, Kiyoshi Takeda
Publikováno v:
Annals of the Rheumatic Diseases. 82:621-629
ObjectivesPrevotella copriis considered to be a contributing factor in rheumatoid arthritis (RA). However, in some non-Westernised countries, healthy individuals also harbour an abundance ofP. copriin the intestine. This study investigated the pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb71c65be41b0b537ad697b56170105
https://doi.org/10.1136/ard-2022-222881
https://doi.org/10.1136/ard-2022-222881
Autor:
Natsuki Nakagawa, Yoshiko Hashii, Hisako Kayama, Ryu Okumura, Hiroko Nakajima, Hikaru Minagawa, Soyoko Morimoto, Fumihiro Fujiki, Jun Nakata, Toshiro Shirakawa, Takane Katayama, Kiyoshi Takeda, Akihiro Tsuboi, Keiichi Ozono
Publikováno v:
Cancer Immunology, Immunotherapy. 72:39-53
Wilms’ tumor 1 (WT1) is a promising tumor-associated antigen for cancer immunotherapy. We developed an oral protein vaccine platform composed of WT1-anchored, genetically engineered Bifidobacterium longum (B. longum) and conducted an in vivo study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b62b2f682184424c4cdfae1acae8f1
https://doi.org/10.1007/s00262-022-03214-4
https://doi.org/10.1007/s00262-022-03214-4
Autor:
Thanyakorn Chalalai, Naganori Kamiyama, Benjawan Saechue, Nozomi Sachi, Sotaro Ozaka, Shimpei Ariki, Astri Dewayani, Yasuhiro Soga, Yomei Kagoshima, Supanuch Ekronarongchai, Ryu Okumura, Hisako Kayama, Kiyoshi Takeda, Takashi Kobayashi
Publikováno v:
Biochemical and Biophysical Research Communications.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d53f9fc919741f0595ca599417c213f
https://doi.org/10.1016/j.bbrc.2023.05.059
https://doi.org/10.1016/j.bbrc.2023.05.059
Autor:
Qizhi Liu, Eiji Umemoto, Naoki Morita, Hisako Kayama, Yoshihiro Baba, Tomohiro Kurosaki, Ryu Okumura, Kiyoshi Takeda
Publikováno v:
International Immunology. 34:343-352
CX3CR1high myeloid cells in the small intestine mediate the induction of oral tolerance by driving regulatory T (Treg) cells. Bacterial metabolites, e.g. pyruvate and lactate, induce a dendrite extension of CX3CR1high myeloid cells into the intestina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2816dadd72b98276b52003e6211c2461
https://doi.org/10.1093/intimm/dxac010
https://doi.org/10.1093/intimm/dxac010