Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Ryu, Nagata"'
Autor:
Sayaka Oda, Kazuhiro Nishiyama, Yuka Furumoto, Yohei Yamaguchi, Akiyuki Nishimura, Xiaokang Tang, Yuri Kato, Takuro Numaga-Tomita, Toshiyuki Kaneko, Supachoke Mangmool, Takuya Kuroda, Reishin Okubo, Makoto Sanbo, Masumi Hirabayashi, Yoji Sato, Yasuaki Nakagawa, Koichiro Kuwahara, Ryu Nagata, Gentaro Iribe, Yasuo Mori, Motohiro Nishida
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Baroreflex control of cardiac contractility is essential to maintain cardiocirculatory homeostasis. Here, Oda et al show that α1 adrenoceptor-stimulated Zn2+ entry through TRPC6 channels boosts β adrenoceptor-dependent myocardial positive inotropy.
Externí odkaz:
https://doaj.org/article/e32d11cf533d41b3a910892e7315812a
Autor:
Sayaka, Oda, Kazuhiro, Nishiyama, Yuka, Furumoto, Yohei, Yamaguchi, Akiyuki, Nishimura, Xiaokang, Tang, Yuri, Kato, Takuro, Numaga-Tomita, Toshiyuki, Kaneko, Supachoke, Mangmool, Takuya, Kuroda, Reishin, Okubo, Makoto, Sanbo, Masumi, Hirabayashi, Yoji, Sato, Yasuaki, Nakagawa, Koichiro, Kuwahara, Ryu, Nagata, Gentaro, Iribe, Yasuo, Mori, Motohiro, Nishida
Publikováno v:
Nature communications. 13(1)
Baroreflex control of cardiac contraction (positive inotropy) through sympathetic nerve activation is important for cardiocirculatory homeostasis. Transient receptor potential canonical subfamily (TRPC) channels are responsible for α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::681c70d92cd60279bef1bfe186021bdb
https://pubmed.ncbi.nlm.nih.gov/36289215
https://pubmed.ncbi.nlm.nih.gov/36289215
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 96:2-B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7145d28b0910439004ff3b66d529b4af
https://doi.org/10.1254/jpssuppl.96.0_2-b-p-160
https://doi.org/10.1254/jpssuppl.96.0_2-b-p-160
Autor:
Masahito Shimojo, Yasuo Mori, Satoshi Obika, Motohiro Nishida, Yuuya Kasahara, Ryu Nagata, Tomorrow Amatani
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 94:3-P2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a522de57efe0f4f50bddabefeb76c4e1
https://doi.org/10.1254/jpssuppl.94.0_3-p2-42
https://doi.org/10.1254/jpssuppl.94.0_3-p2-42
Autor:
Hiroshi Nakagawa, Hideharu Hase, Seishiro Sawamura, Masayuki X. Mori, Kyosuke Hino, Akito Nakao, Ryuji Inoue, Jun Tanikawa, Shigeki Kiyonaka, Mitsuru Hirano, Yaopeng Hu, Rachapun Rotrattanadumrong, Yasuo Mori, Motohiro Nishida, Ryu Nagata, Masahiko Hatano, Yoshinori Takada, Tetsuya Kawamura
Publikováno v:
Molecular Pharmacology. 89:348-363
Transient receptor potential canonical (TRPC) proteins form Ca(2+)-permeable cation channels activated upon stimulation of metabotropic receptors coupled to phospholipase C. Among the TRPC subfamily, TRPC3 and TRPC6 channels activated directly by dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7503c04cc9e9d671ffebcb7e1d3ba0
https://doi.org/10.1124/mol.115.102863
https://doi.org/10.1124/mol.115.102863
Autor:
Tomoko Horisawa, Kumiko Tokuda, Osamu Ichikawa, Kazuhiko Okazaki, Hiroyuki Nakahira, Kazuto Yamazaki, Megumi Maruyama, Ryu Nagata
Publikováno v:
Neurochemistry International. 61:1133-1143
Lurasidone is a novel antipsychotic agent with high affinity for dopamine D(2), 5-hydroxyltryptamine 5-HT(2A), and 5-HT(7) receptors. Lurasidone has negligible affinity for histamine H(1) and muscarinic M(1) receptors, which are thought to contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e167b39123352b2e47c94d2c8dc8a1c1
https://doi.org/10.1016/j.neuint.2012.08.005
https://doi.org/10.1016/j.neuint.2012.08.005
Autor:
Eiji Sugaru, Mutsuo Taiji, Teruhisa Tokunaga, Jun Nagamine, Makoto Kitoh, Michiko Ono-Kishino, Ryu Nagata, Tsutomu Nakagawa, Tsuyoshi Tsujimura
Publikováno v:
Biomedical Research. 30:177-182
Pulmonary fibrosis is a progressive and lethal lung disease characterized by accumulation of ECM and loss of pulmonary function. However, no cure exists for this disease, and current treatments often fail to slow its progression or relieve its sympto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cf8a4ead6f3be3cc2108de5226fe4e
https://doi.org/10.2220/biomedres.30.177
https://doi.org/10.2220/biomedres.30.177
Autor:
Mutsuo Taiji, Makoto Kitoh, Tsutomu Nakagawa, Eiji Sugaru, Jun Nagamine, Tsuyoshi Tsujimura, Michiko Ono-Kishino, Ryu Nagata, Teruhisa Tokunaga
Publikováno v:
Biological and Pharmaceutical Bulletin. 32:1991-1996
The number of patients with chronic kidney disease (CKD) has continuously grown worldwide. Treatment with antihypertensive agents reduces the rate of progression of CKD, however, there is still a large unmet need to develop strategies for the treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcef10ef2d8f297b858a18927bc126a8
https://doi.org/10.1248/bpb.32.1991
https://doi.org/10.1248/bpb.32.1991
Autor:
Eiji Sugaru, Jun Nagamine, Tsuyoshi Tsujimura, Ryu Nagata, Michiko Ono-Kishino, Makoto Kitoh, Tsutomu Nakagawa, Teruhisa Tokunaga, Mutsuo Taiji
Publikováno v:
Nephron Experimental Nephrology. 110:I-VI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52723a0684c51a3d50d27ce0c239b776
https://doi.org/10.1159/000187123
https://doi.org/10.1159/000187123
Autor:
Jun Nagamine, Ryu Nagata, W. Ewan Hume, Mutsuo Taiji, Eiji Sugaru, Makoto Kitoh, Michiko Ono-Kishino, Tsutomu Nakagawa, Teruhisa Tokunaga
Publikováno v:
Nephron Experimental Nephrology. 105:e45-e52
Background/Aims: Diabetic nephropathy is the main cause of end-stage renal disease. Previously we have demonstrated that SMP-534 (an antifibrotic agent) prevents the development of diabetic nephropathy in db/db mouse and that combined treatment with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9467a4af139c1cbc5db0c4c50e1cea53
https://doi.org/10.1159/000097603
https://doi.org/10.1159/000097603