Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Ryszard Kierzek"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 64-74 (2022)
The naturally occurring structure and biological functions of RNA are correlated, which includes hammerhead ribozymes. We proposed new variants of hammerhead ribozymes targeting conserved structural motifs of segment 5 of influenza A virus (IAV) (+)R
Externí odkaz:
https://doaj.org/article/c3b9450fc42640b1a7cb711e7219f250
Autor:
Elzbieta Kierzek, Xiaoju Zhang, Richard M. Watson, Scott D. Kennedy, Marta Szabat, Ryszard Kierzek, David H. Mathews
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
RNA folding free energy nearest neighbor parameters were determined for sequences with the nucleotide m6A. The RNAstructure software package can accommodate modified nucleotides, enabling secondary structure prediction of sequences with m6A.
Externí odkaz:
https://doaj.org/article/36487304e62d424d88d28d128569910f
Autor:
Marta Soszynska-Jozwiak, Agnieszka Ruszkowska, Ryszard Kierzek, Collin A. O’Leary, Walter N. Moss, Elzbieta Kierzek
Publikováno v:
Viruses, Vol 14, Iss 2, p 322 (2022)
SARS-CoV-2 belongs to the Coronavirinae family. Like other coronaviruses, SARS-CoV-2 is enveloped and possesses a positive-sense, single-stranded RNA genome of ~30 kb. Genomic RNA is used as the template for replication and transcription. During thes
Externí odkaz:
https://doaj.org/article/9938f5610965473687afdd90a403215c
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract The occurrence of triplexes in vivo has been well documented and is determined by the presence of long homopurine-homopyrimidine tracts. The formation of these structures is the result of conformational changes that occur in the duplex, whic
Externí odkaz:
https://doaj.org/article/c556e732ad6a44c9aecdd40fa9be3673
Autor:
Weronika Kotkowiak, Jolanta Lisowiec-Wachnicka, Jakub Grynda, Ryszard Kierzek, Jesper Wengel, Anna Pasternak
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 304-316 (2018)
Thrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I. This 15-nt DNA o
Externí odkaz:
https://doaj.org/article/4fb784a3730b4c62b82c7cf5dcfb64e8
Autor:
Dorota Gudanis, Karolina Zielińska, Daniel Baranowski, Ryszard Kierzek, Piotr Kozłowski, Zofia Gdaniec
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1236 (2021)
In this paper, a method to discriminate between two target RNA sequences that differ by one nucleotide only is presented. The method relies on the formation of alternative structures, i.e., quadruplex–duplex hybrid (QDH) and duplex with dangling en
Externí odkaz:
https://doaj.org/article/79085307652a44afbc1eac5e7892b474
Autor:
Dagny Lorent, Rafal Nowak, Carolina Roxo, Elzbieta Lenartowicz, Aleksandra Makarewicz, Bartosz Zaremba, Szymon Nowak, Lukasz Kuszel, Jerzy Stefaniak, Ryszard Kierzek, Pawel Zmora
Publikováno v:
Vaccines, Vol 9, Iss 6, p 541 (2021)
In comparison to other European countries, during the first months of the COVID-19 pandemic, Poland reported a relatively low number of confirmed cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. To estimate the scale
Externí odkaz:
https://doaj.org/article/83b267b0e71a48f9bef8bd8b54a22037
Autor:
Paula Michalak, Julita Piasecka, Barbara Szutkowska, Ryszard Kierzek, Ewa Biala, Walter N. Moss, Elzbieta Kierzek
Publikováno v:
Viruses, Vol 13, Iss 3, p 525 (2021)
The functionality of RNA is fully dependent on its structure. For the influenza A virus (IAV), there are confirmed structural motifs mediating processes which are important for the viral replication cycle, including genome assembly and viral packagin
Externí odkaz:
https://doaj.org/article/5c1ae760fe7f41beb14aede7b3bf1ba8
Autor:
Marta Szabat, Dagny Lorent, Tomasz Czapik, Maria Tomaszewska, Elzbieta Kierzek, Ryszard Kierzek
Publikováno v:
Pathogens, Vol 9, Iss 11, p 925 (2020)
Influenza is an important research subject around the world because of its threat to humanity. Influenza A virus (IAV) causes seasonal epidemics and sporadic, but dangerous pandemics. A rapid antigen changes and recombination of the viral RNA genome
Externí odkaz:
https://doaj.org/article/6598574638c84563987401969d662228
Autor:
Szymon P. Nowak, Paweł Zmora, Łukasz Pielok, Łukasz Kuszel, Ryszard Kierzek, Jerzy Stefaniak, Małgorzata Paul
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 9, Pp 1772-1773 (2019)
We report a case of Plasmodium knowlesi malaria imported to central Europe from Southeast Asia. Laboratory suspicion of P. knowlesi infection was based on the presence of atypical developmental forms of the parasite in Giemsa-stained microscopic smea
Externí odkaz:
https://doaj.org/article/0690ac81a31b42039787d76576471ec8