Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ryouta Maeda"'
Autor:
Tomohiro Onishi, Ryouta Maeda, Michiko Terada, Sho Sato, Takahiro Fujii, Masahiro Ito, Kentaro Hashikami, Tomohiro Kawamoto, Maiko Tanaka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Accumulation of tau protein is a key pathology of age-related neurodegenerative diseases such as Alzheimer's disease and progressive supranuclear palsy. Those diseases are collectively termed tauopathies. Tau pathology is associated with axo
Externí odkaz:
https://doaj.org/article/67cf6d93ad1a49af82682f07692cec8c
Autor:
Takao Mandai, Yuu Sako, Emi Kurimoto, Yuji Shimizu, Minoru Nakamura, Makoto Fushimi, Ryouta Maeda, Maki Miyamoto, Haruhide Kimura
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract M1 muscarinic acetylcholine receptor (M1R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M1R activation causes gastrointestinal (GI) side effects in an
Externí odkaz:
https://doaj.org/article/1996db5c1bb74209a2c1a0e72f2d9b18
Autor:
Tomohiro Ohashi, Tomoteru Yamasaki, Yasuyuki Debori, Tatsuki Koike, Tomokazu Kusumoto, Ryouta Maeda, Masayuki Fujinaga, Akito Hata, Takeshi Wakabayashi, Yasushi Hattori, Ming-Rong Zhang, Miyanohana Yuhei, Ryo Yamashita, Maki Miyamoto, Yiding Zhang, Hidekatsu Wakizaka
Publikováno v:
Journal of Medicinal Chemistry. 64:11990-12002
Diacylglycerol kinase gamma (DGKγ) is a subtype of DGK enzyme, which catalyzes ATP-dependent conversion of diacylglycerol to phosphatidic acid. DGKγ, localized in the brain, plays an important role in the central nervous system. However, its functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fed7abf826a7d32a1858fd3c81b3bef
https://doi.org/10.1021/acs.jmedchem.1c00584
https://doi.org/10.1021/acs.jmedchem.1c00584
Autor:
Yasushi, Hattori, Tomoteru, Yamasaki, Tomohiro, Ohashi, Yuhei, Miyanohana, Tomokazu, Kusumoto, Ryouta, Maeda, Maki, Miyamoto, Yasuyuki, Debori, Akito, Hata, Yiding, Zhang, Hidekatsu, Wakizaka, Takeshi, Wakabayashi, Masayuki, Fujinaga, Ryo, Yamashita, Ming-Rong, Zhang, Tatsuki, Koike
Publikováno v:
Journal of medicinal chemistry. 64(16)
Diacylglycerol kinase gamma (DGKγ) is a subtype of DGK enzyme, which catalyzes ATP-dependent conversion of diacylglycerol to phosphatidic acid. DGKγ, localized in the brain, plays an important role in the central nervous system. However, its functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::637daea17022fe867db87f04fa2bb855
https://pubmed.ncbi.nlm.nih.gov/34347478
https://pubmed.ncbi.nlm.nih.gov/34347478
Autor:
Yuji Shimizu, Yuu Sako, Takao Mandai, Haruhide Kimura, Emi Kurimoto, Ryouta Maeda, Maki Miyamoto, Makoto Fushimi, Minoru Nakamura
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
M1 muscarinic acetylcholine receptor (M1R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M1R activation causes gastrointestinal (GI) side effects in animals. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72150c40b53a4ad05b7794f62f164063
https://doaj.org/article/1996db5c1bb74209a2c1a0e72f2d9b18
https://doaj.org/article/1996db5c1bb74209a2c1a0e72f2d9b18
Autor:
Takao, Mandai, Yuu, Sako, Emi, Kurimoto, Yuji, Shimizu, Minoru, Nakamura, Makoto, Fushimi, Ryouta, Maeda, Maki, Miyamoto, Haruhide, Kimura
Publikováno v:
Pharmacology Research & Perspectives
M1 muscarinic acetylcholine receptor (M1R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M1R activation causes gastrointestinal (GI) side effects in animals. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37e078f1c932cf86cd270bd3cd9e9cd6
https://pubmed.ncbi.nlm.nih.gov/31990455
https://pubmed.ncbi.nlm.nih.gov/31990455
Autor:
Takao Mandai, Yuu Sako, Emi Kurimoto, Yuji Shimizu, Minoru Nakamura, Makoto Fushimi, Ryouta Maeda, Maki Miyamoto, Haruhide Kimura
Publikováno v:
Pharmacology Research & Perspectives; Feb2020, Vol. 8 Issue 1, p1-17, 17p
Autor:
Yuki Ooshima, Yoshio Matsumoto, Takashi Yano, Satoshi Yamamoto, Tadatoshi Hashimoto, Michiyasu Takeyama, Kunio Matsuoka, Hideki Takahashi, Ryouta Maeda, Mitsugu Nakata, Sayuri Watanabe
Publikováno v:
Transgenic Research. 22:537-547
Gene-targeting technology using mouse embryonic stem (ES) cells has become the "gold standard" for analyzing gene functions and producing disease models. Recently, genetically modified mice with multiple mutations have increasingly been produced to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa09fb68d75d1d71d07c9357e266b735
https://doi.org/10.1007/s11248-012-9651-x
https://doi.org/10.1007/s11248-012-9651-x
Autor:
Shunsuke Hasegawa, Nori Mamiya, Emiko Okano, Ryouta Maeda, Valentina Mercaldo, Akinobu Suzuki, Long Jun Wu, Ming Gao Zhao, Takuya Mukawa, Hiroki Toyoda, Hotaka Fukushima, Yue Zhang, Satoshi Kida, Kengo Endoh, Hui Xu, Min Zhuo, Yuze Shang, Sheena A. Josselyn, Miho Ohta, Taku Iwamoto
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(24)
Unraveling the mechanisms by which the molecular manipulation of genes of interest enhances cognitive function is important to establish genetic therapies for cognitive disorders. Although CREB is thought to positively regulate formation of long-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2c13834ca96184dcf408c7825f058b
https://pubmed.ncbi.nlm.nih.gov/21677163
https://pubmed.ncbi.nlm.nih.gov/21677163
Autor:
Junji Matsui, Makiko Kawamoto, Jun Terauchi, Mitsuhiro Hirode, Mitsuru Kakihana, Naoki Tarui, Hideki Takahashi, Masaomi Miyamoto, Masumi Sagayama, Kazuko Hirai, Kaneyoshi Kato, Hiroaki Fukumoto, Yasufumi Sakura, Ryouta Maeda, Takeshi Iwatsubo, Taisuke Tomita
We discovered a nonpeptidic compound, TAK-070, that inhibited BACE1, a rate-limiting protease for the generation of Abeta peptides that are considered causative for Alzheimer's disease (AD), in a noncompetitive manner. TAK-070 bound to full-length BA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29ac9e4a1db650c8681edf0c0ee46c3
https://europepmc.org/articles/PMC6633483/
https://europepmc.org/articles/PMC6633483/
