Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ryoukichi Koyama"'
Autor:
Junya Shirai, Yoshiyuki Fukase, Keiko Koga, Ryoukichi Koyama, Hideyuki Nakagawa, Isaac Hoffman, Bi-Ching Sang, Mitsunori Kono, Toshitake Okui, Satoshi Yamamoto, Yasushi Fujitani, Masaharu Nakayama, Yoshihide Tomata, Robert J. Skene, Kazuko Yonemori, Atsuko Ochida, Masashi Yamasaki, Ayumu Sato
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:721-736
Novel small molecules were synthesized and evaluated as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for the treatment of inflammatory and autoimmune diseases. A hit compound, 1, was discovered by high-throughput s
Autor:
Ryoukichi Koyama, Geza Ambrus-Aikelin, Hideyuki Nakagawa, Satoshi Yamamoto, Masaharu Nakayama, Junya Shirai, Bi-Ching Sang, Atsuko Ochida, Yusuke Kamada, Mitsunori Kono
Publikováno v:
Pharmacology. 102(5-6)
Background/Aims: Retinoid-related orphan receptor gamma t (RORγt) is a master regulator of T helper 17 cells that plays a pivotal role in the production of inflammatory cytokines including interleukin (IL)-17. Therefore, RORγt has attracted much at
Autor:
Atsuko Ochida, Yoshihide Tomata, Wes Lane, Isaac Hoffman, Masaharu Nakayama, Hideyuki Nakagawa, Ayumu Sato, Tetsuji Kawamoto, Mitsunori Kono, Toshitake Okui, Shinichi Masada, Mikio Shirasaki, Masashi Yamasaki, Yasushi Fujitani, Akira Shibata, Keiko Uga, Junya Shirai, Yoshiyuki Fukase, Kazuko Yonemori, Ryoukichi Koyama, Bi-Ching Sang, Robert J. Skene, Keiko Koga, Satoshi Yamamoto
Publikováno v:
Bioorganicmedicinal chemistry. 26(2)
A series of novel phenylglycinamides as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists were discovered through optimization of a high-throughput screen hit 1. (R)-N-(2-((3,5-Difluoro-4-(trimethylsilyl)phenyl) amino)-
Autor:
Noriyuki Nii, Nobuyuki Negoro, Shinkichi Suzuki, Ryoukichi Koyama, Taisuke Katoh, Masato Yoshikawa, Ryosuke Arai, Takatoshi Yogo, Yoshihide Tomata, Takeshi Yamamoto
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(5)
We describe a methodology for quick development of fluorescent probes with the desired potency for the target of interest by using a method of parallel synthesis, termed as Parallel Fluorescent Probe Synthesis (Parallel-FPS). BODIPY FL propionic acid
Autor:
Natalia Nikolaevna Samsonova, Hiroyuki Yamanaka, Tomohiro Kodera, Junichi Mano, Takashi Kawashima, Sakayu Shimizu, Ryoukichi Koyama, Jun Ogawa, Kenzo Yokozeki, Sergey Vasilievich Smirnov, Makoto Hibi
Publikováno v:
Applied Microbiology and Biotechnology. 89:1929-1938
4-Hydroxyisoleucine (HIL) found in fenugreek seeds has insulinotropic and anti-obesity effects and is expected to be a novel orally active drug for insulin-independent diabetes. Here, we show that the newly isolated strain Bacillus thuringiensis 2e2