Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Ryou-u Takahashi"'
Autor:
Yuki Yamamoto, Ryou-u Takahashi, Masaki Kinehara, Kimiyoshi Yano, Tatsuya Kuramoto, Akira Shimamoto, Hidetoshi Tahara
Publikováno v:
Genes, Vol 15, Iss 5, p 543 (2024)
Cellular senescence is an irreversible growth arrest that acts as a barrier to cancer initiation and progression. Histone alteration is one of the major events during replicative senescence. However, little is known about the function of H3.3 in cell
Externí odkaz:
https://doaj.org/article/6913d6121c284a4895cd746f405cad73
Autor:
Jiayan Han, Soichiro Hayashi, Ryou-u Takahashi, Ryosuke Hirohata, Tomoaki Kurokawa, Mizuki Tashiro, Yuki Yamamoto, Morihito Okada, Hidetoshi Tahara
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 24, p 7385 (2022)
Despite significant advances in therapeutics for esophageal cancer (ESC) in the past decade, it remains the sixth most fatal malignancy, with a poor 5-year survival rate (approximately 10%). There is an urgent need to improve the timely diagnosis to
Externí odkaz:
https://doaj.org/article/54d1941cb0724136b77fdcc977d76ab7
Autor:
Yoshitomo Shiroma, Go Fujita, Takuya Yamamoto, Ryou-u Takahashi, Ashutosh Kumar, Kam Y. J. Zhang, Akihiro Ito, Hiroyuki Osada, Minoru Yoshida, Hidetoshi Tahara
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9150 (2020)
Nuclear factor-κB (NF-κB) is an important transcription factor involved in various biological functions, including tumorigenesis. Hence, NF-κB has attracted attention as a target factor for cancer treatment, leading to the development of several i
Externí odkaz:
https://doaj.org/article/bd43e8cc63f8408a916d55569c0be2ab
Autor:
Marta Prieto-Vila, Iwao Shimomura, Akiko Kogure, Wataru Usuba, Ryou-u Takahashi, Takahiro Ochiya, Yusuke Yamamoto
Publikováno v:
Molecules, Vol 25, Iss 11, p 2576 (2020)
Drug resistance is a major problem for breast cancer patients. Docetaxel is an anti-mitotic agent that serves as first line of treatment in metastatic breast cancer, however it is susceptible to cellular drug resistance. Drug-resistant cells are able
Externí odkaz:
https://doaj.org/article/af604e2336964818bcdd5b56e9236350
Autor:
Junichiro Chikuda, Kurataka Otsuka, Iwao Shimomura, Kagenori Ito, Hiroaki Miyazaki, Ryou-u Takahashi, Masahiro Nagasaki, Yoshiki Mukudai, Takahiro Ochiya, Toshikazu Shimane, Tatsuo Shirota, Yusuke Yamamoto
Publikováno v:
Cancers, Vol 12, Iss 4, p 856 (2020)
Cisplatin (cis-diamminedichloroplatinum II [CDDP] ) is a well-known chemotherapeutic drug that has been used for the treatment of various types of human cancers, including head and neck cancer. Cisplatin exerts anticancer effects by causing DNA damag
Externí odkaz:
https://doaj.org/article/50ea540c513f45939c65b1fd15954542
Publikováno v:
Cancers, Vol 7, Iss 2, Pp 598-616 (2015)
MicroRNAs (miRNAs) constitute a large family of small, approximately 20–22 nucleotide, non-coding RNAs that regulate the expression of target genes, mainly at the post-transcriptional level. Accumulating lines of evidence have indicated that miRNAs
Externí odkaz:
https://doaj.org/article/e615415275f0483893a1c606c0a603f3
Autor:
Ai Hironaka-Mitsuhashi, Juntaro Matsuzaki, Ryou-U Takahashi, Masayuki Yoshida, Yutaka Nezu, Yusuke Yamamoto, Sho Shiino, Takayuki Kinoshita, Toshikazu Ushijima, Nobuyoshi Hiraoka, Chikako Shimizu, Kenji Tamura, Takahiro Ochiya
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187638 (2017)
Since breast cancers in young women are generally aggressive, young patients tend to be intensively treated with anti-cancer drugs. To optimize the strategy for treatment, particularly in young women, prognostic biomarkers are urgently required. The
Externí odkaz:
https://doaj.org/article/22c9b3dad7134c4d891bf62de6921338
Autor:
Takahiro Ochiya, Ryo Matoba, Shoji Tajima, Kenta Nakai, Asao Fujiyama, Mika Kimura, Takuro Horii, Atsushi Toyoda, Riu Yamashita, Ryou-u Takahashi, Sumiyo Morita, Izuho Hatada
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 7, Pp 8259-8272 (2012)
DNA methylation of promoters is linked to transcriptional silencing of protein-coding genes, and its alteration plays important roles in cancer formation. For example, hypermethylation of tumor suppressor genes has been seen in some cancers. Alterati
Externí odkaz:
https://doaj.org/article/7cfdae1dfc6f4d9585448f34e0228723
Publikováno v:
Cancers, Vol 3, Iss 1, Pp 1311-1328 (2011)
The cancer stem cell (CSC) theory is generally acknowledged as an important field of cancer research, not only as an academic matter but also as a crucial aspect of clinical practice. CSCs share a variety of biological properties with normal somatic
Externí odkaz:
https://doaj.org/article/6fb5fabce7884136832c4165c49a7be6
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2574 (2017)
Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem cells (CSCs), a subset of cells within the tumor with the potential for self-renewal, differentiation and tumorigenicity, are thought to be the major cause of
Externí odkaz:
https://doaj.org/article/fdd7ef0e6ba54bd780802e7d2fc8cdaa