Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ryotaro Yabe"'
Autor:
Ryotaro Yabe, Shunya Tsuji, Satoru Mochida, Tsuyoshi Ikehara, Tatsuya Usui, Takashi Ohama, Koichi Sato
Publikováno v:
FEBS Open Bio, Vol 8, Iss 9, Pp 1486-1496 (2018)
Reversible methyl‐esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme. Accumulating evidence links PP2Ac methylation to diseases, including cancer
Externí odkaz:
https://doaj.org/article/aa84b8c027ea43db99e5813fce983440
Autor:
Satoru Kake, Shunya Tsuji, Shuhei Enjoji, Sayaka Hanasaki, Hiroshi Hayase, Ryotaro Yabe, Yuiko Tanaka, Takayuki Nakagawa, Hao-Ping Liu, Shih-Chieh Chang, Tatsuya Usui, Takashi Ohama, Koichi Sato
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Canine mammary tumor is the most common neoplasm in female dogs, and it has generated considerable attention as a translational model for human breast cancer. Ser/Thr protein phosphatase 2A (PP2A) plays a critical role as a tumor suppressor,
Externí odkaz:
https://doaj.org/article/9d3996734a2e4ea98d3f019b4c72c5de
Autor:
Tatsuya Usui, Masashi Sakurai, Shuhei Enjoji, Hideyoshi Kawasaki, Koji Umata, Takashi Ohama, Nobuyuki Fujiwara, Ryotaro Yabe, Shunya Tsuji, Hideyuki Yamawaki, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Koichi Sato
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Tumor microenvironment has been implicated in tumor development and progression. As a three-dimensional tumor microenvironment model, air liquid interface (ALI) organoid culture from oncogene transgenic mouse gastrointestinal tissues was recently pro
Externí odkaz:
https://doaj.org/article/fc8bb372c4704bf9b693b80671eeaa11
Autor:
Ryotaro Yabe, Akane Miura, Tatsuya Usui, Ingrid Mudrak, Egon Ogris, Takashi Ohama, Koichi Sato
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145226 (2015)
Protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent signaling pathways. Protein phosphatase methyl esterase (PME-1) catalyzes specifically the d
Externí odkaz:
https://doaj.org/article/b9e1f577414e4c8a9b168a027e3190a8
Autor:
Sana Ando, Masashi Sakurai, Shusaku Shibutani, Nobuyuki Kimura, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Ryotaro Yabe, Takashi Ohama, Koichi Sato
Publikováno v:
The Journal of Biochemistry. 173:435-445
The abnormal activity of PP2A, a dominant member of type 2A serine/threonine protein phosphatase, has been implicated in the development of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). PP2A is a holoenzyme, and protein methylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cbf9500db5e8348d22fd2230b76d7af
https://doi.org/10.1093/jb/mvad006
https://doi.org/10.1093/jb/mvad006
Autor:
Koichi Sato, Takashi Ohama, Tatsuya Usui, Yoshitaka Hippo, Tetsuya Matsuura, Michael P. Vitek, Masanobu Oshima, Hiroko Oshima, Hiroaki Nagano, Shoichi Hazama, Shigefumi Yoshino, Hiroko Takenouchi, Yusuke Sakai, Masashi Sakurai, Hideyoshi Kawasaki, Kazuhiro Yoshimura, Shunya Tsuji, Ryotaro Yabe, Shuhei Enjoji
Gastric cancer is the fifth most common malignancy and the third leading cause of cancer-related deaths worldwide. Chemotherapies against gastric cancer often fail, with cancer recurrence due potentially to the persistence of cancer stem cells. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a864b489e0b4324020de729a78cd2f2
https://doi.org/10.1158/1541-7786.c.6540399.v1
https://doi.org/10.1158/1541-7786.c.6540399.v1
Autor:
Koichi Sato, Takashi Ohama, Tatsuya Usui, Yoshitaka Hippo, Tetsuya Matsuura, Michael P. Vitek, Masanobu Oshima, Hiroko Oshima, Hiroaki Nagano, Shoichi Hazama, Shigefumi Yoshino, Hiroko Takenouchi, Yusuke Sakai, Masashi Sakurai, Hideyoshi Kawasaki, Kazuhiro Yoshimura, Shunya Tsuji, Ryotaro Yabe, Shuhei Enjoji
This file contains detailed material and methods, and supplemental data related with Fig. 1g, Fig. 2a, b, Fig. 3c, d, Fig. 4a, b, c, Fig. 5c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7502b222c7bf4262af1a17c9faaee87c
https://doi.org/10.1158/1541-7786.22512972
https://doi.org/10.1158/1541-7786.22512972
Autor:
Tsuyoshi Ikehara, Ryotaro Yabe, Shunya Tsuji, Tatsuya Usui, Koichi Sato, Satoru Mochida, Takashi Ohama
Publikováno v:
FEBS Open Bio
Reversible methyl-esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme. Accumulating evidence links PP2Ac methylation to diseases, including cancer an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0b3115f93b0214a1a50d958314a8c0
http://europepmc.org/articles/PMC6120246
http://europepmc.org/articles/PMC6120246
Publikováno v:
The Journal of Veterinary Medical Science
Lymphoma is one of the most common malignant tumors in canine. Protein phosphatase 2A (PP2A), a well-conserved serine/threonine phosphatase, plays a critical role as a tumor suppressor. Perphenazine (PPZ) is one of the phenothiazines and widely used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721aff87961a14d24da9d95093eb8355
https://doi.org/10.1292/jvms.15-0707
https://doi.org/10.1292/jvms.15-0707
Publikováno v:
The Journal of Veterinary Medical Science
SET is an endogenous protein phosphatase 2A (PP2A) inhibitor and is associated with a poor prognosis in human leukemia. Previously, we reported increased SET protein levels in canine lymphoma cell lines and the potential therapeutic application of SE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cfa18dd8846229fafc4125528c7399
https://doi.org/10.1292/jvms.14-0209
https://doi.org/10.1292/jvms.14-0209