Involvement of Mediterranean fever gene mutations in colchicine-responsive enterocolitis: a retrospective cohort studyResearch in context

Autor: Hiroshi Nakase, Kohei Wagatsuma, Taku Kobayashi, Takayuki Matsumoto, Motohiro Esaki, Kenji Watanabe, Reiko Kunisaki, Teruyuki Takeda, Katsuhiro Arai, Takashi Ibuka, Dai Ishikawa, Yuichi Matsuno, Hirotake Sakuraba, Nobuhiro Ueno, Kaoru Yokoyama, Masayuki Saruta, Ryota Hokari, Junji Yokoyama, Shu Tamano, Masanori Nojima, Tadakazu Hisamatsu, Shusaku Yoshikawa, Sohachi Nanjo, Akira Andoh, Takeshi Kimura, Makoto Ooi, Ryosuke Kiyomori, Nobuo Aoyama, Fumihito Hirai, Atsushi Yamaushi, Masanao Nakamura, Fumikazu Koyama, Shuhei Hosomi, Kazuki Kakimoto, Satoshi Motoya, Ryosuke Sakemi, Hideo Suzuki, Tadashi Hosoya, Ken Takeuchi, Manabu Shiraki, Hideyuki Koide, Ichiro Takeuchi, Yosuke Furui, Kento Yoshida, Ayaka Minemura, Asami Matsumoto, Kentaro Oka

Publikováno v: EBioMedicine, Vol 110, Iss , Pp 105454- (2024)

Summary: Background: The involvement of Mediterranean fever (MEFV) gene mutations in patients with inflammatory bowel disease unclassified (IBDU) remains unclear. This study aimed to determine the clinical characteristics and responsiveness to colchi

Externí odkaz: https://doaj.org/article/65aa18ec7b90480d9069fe49057c33ed

Final Analysis of COVID-19 Patients With Inflammatory Bowel Disease in Japan (J-COSMOS): A Multicenter Registry Cohort Study

Autor: Hiroshi Nakase, Yuki Hayashi, Yoshihiro Yokoyama, Takayuki Matsumoto, Minoru Matsuura, Hideki Iijima, Katsuyoshi Matsuoka, Naoki Ohmiya, Shunji Ishihara, Fumihito Hirai, Daiki Abukawa, Tadakazu Hisamatsu, Makoto Sasaki, Masahiro Iizuka, Mikihiro Fujiya, Fukunori Kinjo, Shiro Nakamura, Noriko Kamata, Yuri Etani, Fumiaki Ueno, Sakiko Hiraoka, Takeo Kondo, Takashi Kagaya, Makoto Naganuma, Kiyonori Kobayashi, Taku Kobayashi, Shuji Yamamoto, Yuji Naito, Yoki Furuta, Keichi Mitsuyama, Yu Hashimoto, Katsuhiro Arai, Shingo Kato, Itaru Iwama, Motohiro Esaki, Hiroki Tanaka, Satoshi Motoya, Atsuo Maemoto, Toshifumi Ashida, Nobuaki Nishimata, Shigeaki Aono, Akira Andoh, Hironori Yamamoto, Toshiaki Shimizu, Maeda Yasuharu, Kenji Kinoshita, Katuyuki Fukuda, Jun Kato, Ken Takeuchi, Masakazu Nagahori, Masakatsu Fukuzawa, Masayuki Saruta, Takayoshi Suzuki, Michio Itabashi, Masaru Shinozaki, Soichiro Ishihara, Naoki Yoshimura, Yoichi Kakuta, Kenichi Takahashi, Keiichi Tominaga, Ryosuke Sakemi, Sohachi Nanjo, Shusaku Yoshikawa, Keiji Ozeki, Ayako Fuchigami, Takehiko Katsurada, Kenji Watanabe, Hirotake Sakuraba, Takashi Hisabe, Shigeru Iwase, Ryota Hokari, Katsuhiko Nakai, Takeshi Ueda, Shojiro Yamamoto, Kazutaka Koganei, Reiko Kunisaki, Akira Hokama

Publikováno v: Gastro Hep Advances, Vol 2, Iss 8, Pp 1056-1065 (2023)

Background and Aims: Japan has experienced 8 waves of the coronavirus disease 2019 (COVID-19) outbreak over the past 3 years, resulting in an increasing number of deaths and incidence of severe infections. This study aimed to analyze the data from th

Externí odkaz: https://doaj.org/article/6dc0fa435835412099a962069329f0e1

The role of lymphatics in intestinal inflammation

Autor: Ryota Hokari, Akira Tomioka

Publikováno v: Inflammation and Regeneration, Vol 41, Iss 1, Pp 1-7 (2021)

Abstract The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vascular defects have been revealed

Externí odkaz: https://doaj.org/article/880ae1c9dd8347d5a022ddb80456e0f4

Immunoglobulin G4‐related disease accompanying a small intestinal ulcer: A case

Autor: Yuta Yoshidome, Akinori Mizoguchi, Kazuyuki Narimatsu, Shun Takahashi, Dai Hirata, Shinji Ono, Yusuke Onoyama, Seiya Suzuki, Tomoaki Horiuchi, Nanoka Chiya, Keisuke Ikeyama, Hiroyuki Tahara, Akira Tomioka, Suguru Ito, Rina Tanemoto, Shin Nishii, Kenichi Inaba, Nao Sugihara, Yoshinori Hanawa, Kazuki Horiuchi, Akinori Wada, Yoshihiro Akita, Masaaki Higashiyama, Shunsuke Komoto, Kengo Tomita, Shinya Yoshimatsu, Susumu Matsukuma, Ryota Hokari

Publikováno v: DEN Open, Vol 2, Iss 1, Pp n/a-n/a (2022)

Abstract Immunoglobulin (Ig)G4‐related disease (IgG4‐RD) is a systemic condition associated with fibroinflammatory lesions and is characterized by elevated serum IgG4 levels and IgG4‐positive cell infiltration into the affected tissues. It has

Externí odkaz: https://doaj.org/article/e28aba9303aa4dafbcb427ce6d34c107

Lipoprotein Lipase Up‐regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice

Autor: Toshiaki Teratani, Kengo Tomita, Hirotaka Furuhashi, Nao Sugihara, Masaaki Higashiyama, Makoto Nishikawa, Rie Irie, Takeshi Takajo, Akinori Wada, Kazuki Horiuchi, Kenichi Inaba, Yoshinori Hanawa, Naoki Shibuya, Yoshikiyo Okada, Chie Kurihara, Shin Nishii, Akinori Mizoguchi, Hideaki Hozumi, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Junji Yamamoto, Soichiro Miura, Ryota Hokari, Tananori Kanai

Publikováno v: Hepatology Communications, Vol 3, Iss 8, Pp 1098-1112 (2019)

Lipoprotein lipase (LPL) plays a central role in incorporating plasma lipids into tissues and regulates lipid metabolism and energy balance in the human body. Conversely, LPL expression is almost absent in normal adult livers. Therefore, its physiolo

Externí odkaz: https://doaj.org/article/5122bbf478584d92b6b14cf523dfdf52