Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Ryosuke Arakawa"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Intellectual drug doping in athletics by using stimulants that affect central nervous system functions has been diversified. Stimulants are regulated by the World Anti-Doping Agency according to their levels of urinary concentration. Positro
Externí odkaz:
https://doaj.org/article/fe18c220204b45ccbb616173b7bcafda
Publikováno v:
Frontiers in Human Neuroscience, Vol 18 (2024)
IntroductionMental rotation (MR) tasks of body parts involve anatomically interconnected brain systems. The systems are implicated in sensorimotor information integration and activate cortical motor-related areas, corresponding to the execution of si
Externí odkaz:
https://doaj.org/article/48b4fc63bacb42f496f7da6e34125ec9
Autor:
Sangram Nag, Kevin Jia, Ryosuke Arakawa, Prodip Datta, Daniel Scott, Christopher Shaffer, Mohammad Mahdi Moein, Matthew Hutchison, Maciej Kaliszczak, Christer Halldin
Publikováno v:
Molecules, Vol 29, Iss 2, p 427 (2024)
The aim of this study was to measure the brain penetrance and kinetics of BIIB104, a first-in-class AMPA receptor potentiator developed for cognitive impairment associated with schizophrenia. It was recently halted in phase 2 clinical development, an
Externí odkaz:
https://doaj.org/article/f95b2e1bd7d446fcb43ef2d6722832ad
Autor:
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca, John Litchfield, Timothy McCarthy, Richard E. Carson, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a
Externí odkaz:
https://doaj.org/article/0b2d2f0ac72047df80a3f5d00a8935c1
Publikováno v:
BMC Psychiatry, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Background Connecting individuals in need of psychiatric treatment with adequate medical services has been a major strategy for suicide prevention in Japan. By investigating serious suicide attempters admitted to our Critical Care Medical Ce
Externí odkaz:
https://doaj.org/article/e97217864e334aecb8a3b0f37886a570
Autor:
Sangram Nag, Ryosuke Arakawa, Zhisheng Jia, Erik Lachapelle, Lei Zhang, Kevin Maresca, Laigao Chen, Mahabuba Jahan, Timothy Mccarthy, Christer Halldin
Publikováno v:
Molecules, Vol 28, Iss 12, p 4612 (2023)
Muscarinic acetylcholine receptors (mAChR), including M4, draw attention as therapeutic targets for several neurodegenerative diseases including Alzheimer’s disease (AD). PET imaging of M4 positive allosteric modulator (PAM) allows qualification of
Externí odkaz:
https://doaj.org/article/c786115b08284d89ace0c5db57d9ce81
Autor:
Tsuyoshi Nogami, Ryosuke Arakawa, Takeshi Sakayori, Yumiko Ikeda, Yoshiro Okubo, Amane Tateno
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
RationaleSince ephedrine has a dopamine transporter (DAT) inhibitory effect similar to amphetamine, dl-methylephedrine, a derivative of ephedrine, is considered to have the characteristics of a central nervous system stimulant due to the DAT inhibito
Externí odkaz:
https://doaj.org/article/2b36c1e6ce5d474ca6646a6eeb1c9154
Publikováno v:
Neuropsychopharmacology Reports, Vol 40, Iss 2, Pp 114-121 (2020)
Abstract Positron emission tomography (PET) is a non‐invasive imaging method to measure the molecule in vivo. PET imaging can evaluate the central nervous system drugs as target engagement in the human brain. For antipsychotic drugs, adequate dopam
Externí odkaz:
https://doaj.org/article/572320dcf5b84a2e9c3fc24c7a437004
Autor:
Anton Lindberg, Ryosuke Arakawa, Tsuyoshi Nogami, Sangram Nag, Magnus Schou, Charles S. Elmore, Lars Farde, Victor W. Pike, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-8 (2019)
Abstract Background Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist li
Externí odkaz:
https://doaj.org/article/10bc2306d18e432dbaa5a6c3fa933174
Autor:
Ryosuke Arakawa, Per Stenkrona, Akihiro Takano, Sangram Nag, Rafael S. Maior, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Background [11C]-l-deprenyl-D2 is a positron emission tomography (PET) radioligand for measurement of the monoamine oxidase B (MAO-B) activity in vivo brain. The estimation of the test-retest reproducibility is important for accurate interpr
Externí odkaz:
https://doaj.org/article/3baa5c1af8384fa88285f083c1390b49