Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ryosuke Misu"'
Autor:
Daisuke Nishiyama, Haruka Sekiguchi, Nobutaka Fujii, Shinya Oishi, Hiroaki Ohno, Hiroaki Chiba, Yuki Sakai, Ryosuke Misu
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:996-1003
A series of novel 3,4,7-trisubstituted benzofuran derivatives were synthesized, and their binding affinity to κ- (KOR) and μ-opioid receptors (MOR) were evaluated. Several aryl ethers showed moderate binding activities to KOR (IC50=3.9-11 µM) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d635e7aabcc0cbec99854c0f8f0d41c3
https://doi.org/10.1248/cpb.c16-00302
https://doi.org/10.1248/cpb.c16-00302
Autor:
Taro Noguchi, Koki Yamamoto, Shinya Oishi, Hiroaki Okamura, Hiroaki Ohno, Nobutaka Fujii, Fuko Matsuda, Ai Yamada, Takashi Yamamura, Satoshi Ohkura, Ryosuke Misu
Publikováno v:
MedChemComm. 6(3):469-476
Neurokinin B (NKB) regulates the secretion of gonadotropin-releasing hormone (GnRH) in the hypothalamus via activation of the cognate neurokinin-3 receptor (NK3R). The stimulatory effect of NKB and the derivatives on gonadotropin secretion can potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a765d8720b236844131ea3e843f0f8c
http://hdl.handle.net/2433/198453
http://hdl.handle.net/2433/198453
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:6156-6162
There are many natural peptides with multiple N-methylamino acids that exhibit potent attractive biological activities. N-methylation of a peptide bond(s) is also one of the standard approaches in medicinal chemistry of bioactive peptides, to improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c31b6d3b29548abd0d0532d40c5326
https://doi.org/10.1016/j.bmc.2014.08.036
https://doi.org/10.1016/j.bmc.2014.08.036
Autor:
Nobutaka Fujii, Ryosuke Misu, Hiroaki Ohno, Shinya Oishi, Akira Hirasawa, Nahoko Ieda, Kei-ichiro Maeda, Masato Kaneda, Hiroko Tsukamura, Yoshihisa Uenoyama
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3325-3330
Kisspeptins are neuropeptides that induce the secretion of gonadotropin-releasing hormone via the activation of the cognate receptor, G-protein coupled receptor 54 (GPR54). The kisspeptin-GPR54 axis is associated with the onset of puberty and the mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55aa4dad32644e5b34c2cf5d6f54694a
https://doi.org/10.1016/j.bmc.2014.04.052
https://doi.org/10.1016/j.bmc.2014.04.052
Autor:
Masato Kaneda, Nobutaka Fujii, Hiroaki Ohno, Isao Nakanishi, Akira Asai, Ryosuke Misu, Shinya Nakamura, Tomoki Takeuchi, Shinya Oishi, Jun-ichi Sawada
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3171-3179
Structure–activity relationship studies of diaryl amine-type KSP inhibitors were carried out. Diaryl amine derivatives with a pyridine ring or urea group were less active when compared with the parent carboline and carbazole derivatives. Optimizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b5cb9864b42bb45382bea3152e397d
https://doi.org/10.1016/j.bmc.2014.04.008
https://doi.org/10.1016/j.bmc.2014.04.008
Autor:
Stephen C. Peiper, Taro Noguchi, Masato Kaneda, Shohei Setsuda, Nobutaka Fujii, Shinya Oishi, Barry J. Evans, Ryosuke Misu, Hiroaki Ohno, Jean-Marc Navenot
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2628-2631
Kisspeptins, endogenous peptide ligands for GPR54, play an important role in GnRH secretion. Since in vivo administration of kisspeptins induces increased plasma LH levels, GPR54 agonists hold promise as therapeutic agents for the treatment of hormon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d804c17773d6d8c8d8a6e047d4c67696
https://doi.org/10.1016/j.bmcl.2013.02.098
https://doi.org/10.1016/j.bmcl.2013.02.098
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2413-2417
Neurokinin B (NKB) is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R). NKB with the consensus sequence of the tachykinin peptide family also binds to other tachykin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435cd374b5a0c8bd854693509959fc5e
https://doi.org/10.1016/j.bmc.2013.01.036
https://doi.org/10.1016/j.bmc.2013.01.036
Autor:
Yamato Suzuki, Akira Hirasawa, Zengye Hou, Nobutaka Fujii, Misato Yasue, Gozoh Tsujimoto, Yoshinori Takei, Tatsuhide Kure, Isao Nakanishi, Takayoshi Kinoshita, Shinya Oishi, Ryosuke Misu, Kazuo Kitaura, Hiroaki Ohno, Katsumi Murata, Shinya Nakamura
Publikováno v:
Journal of Medicinal Chemistry. 55:2899-2903
Protein kinase CK2 (CK2) is a ubiquitous serine/threonine protein kinase for hundreds of endogenous substrates. CK2 has been considered to be involved in many diseases, including cancers. Herein we report the discovery of a novel ATP-competitive CK2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29572544d81d31e7ef454a4d05e0f42c
https://doi.org/10.1021/jm2015167
https://doi.org/10.1021/jm2015167
Publikováno v:
Journal of neurophysiology. 114(5)
Animals change their behavior in response to sensory cues in the environment as well as their physiological status. For example, it is generally accepted that their sexual behavior is modulated according to seasonal environmental changes or the indiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70914aec8acca510b0ba18f5cf098bb
https://pubmed.ncbi.nlm.nih.gov/26354319
https://pubmed.ncbi.nlm.nih.gov/26354319
Autor:
Nobutaka Fujii, Hiroaki Ohno, Ryota Nabika, Shinya Oishi, Jane E. Ishmael, Takashi L. Suyama, Kerry L. McPhail, Andrew M. Hau, Ryosuke Misu
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(2)
Coibamide A is a highly potent antiproliferative cyclic depsipeptide, which was originally isolated from a Panamanian marine cyanobacterium. In this study, the synthesis of coibamide A has been investigated using Fmoc-based solid-phase peptide synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcf98fefd0bd29056ba6c9dd236f20f
https://pubmed.ncbi.nlm.nih.gov/25488840
https://pubmed.ncbi.nlm.nih.gov/25488840