Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ryoko Takimoto"'
Autor:
Damien Colas, Janice S. Valletta, Ryoko Takimoto-Kimura, Seiji Nishino, Nobuhiro Fujiki, William C. Mobley, Emmanuel Mignot
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 1, Pp 1-7 (2008)
Down syndrome is characterized by a host of behavioral abnormalities including sleep disturbances. Sleep and EEG was studied at the age of 3 months in two mouse models of the condition, Ts65Dn and Ts1Cje, carrying one extra copy of partially overlapp
Externí odkaz:
https://doaj.org/article/7818cf84556d47658b6aac984ae481d1
Autor:
Ryoko Takimoto-Kimura, Ahmad Salehi, Eliezer Masliah, William C. Mobley, Chengbiao Wu, Pavel V. Belichenko, Alexander M. Kleschevnikov
Publikováno v:
J Comp Neurol
Down syndrome (DS) is a neurological disorder causing impaired learning and memory. Partial trisomy 16 mice (Ts65Dn) are a genetic model for DS. Previously, we demonstrated widespread alterations of pre- and postsynaptic elements and physiological ab
Autor:
Ryoko Takimoto-Kimura, Janice S. Valletta, Damien Colas, Emmanuel Mignot, William C. Mobley, Seiji Nishino, Nobuhiro Fujiki
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 1, Pp 1-7 (2008)
Down syndrome is characterized by a host of behavioral abnormalities including sleep disturbances. Sleep and EEG was studied at the age of 3 months in two mouse models of the condition, Ts65Dn and Ts1Cje, carrying one extra copy of partially overlapp
Publikováno v:
Mechanisms of Development. 120:227-240
Patterning events along the anterior-posterior (AP) axis of vertebrate embryos result in the distribution of muscle and bone forming a highly effective functional system. A key aspect of regionalized AP patterning results from variation in the migrat
Autor:
Ryoko Takimoto-Kimura, Alexander M. Kleschevnikov, Ahmad Salehi, Mehrdad Shamloo, J. Laguna, Damien Colas, Mehrdad Faizi, Janice S. Valletta, Paul S. Aisen, William C. Mobley, Steven L. Wagner
Publikováno v:
Science translational medicine. 1(7)
Down syndrome (trisomy 21) is the most common cause of mental retardation in children and leads to marked deficits in contextual learning and memory. In rodents, these tasks require the hippocampus and are mediated by several inputs, particularly tho
Autor:
Mehrdad Faizi, Janice S. Valletta, Ahmad Salehi, Ryoko Takimoto, William C. Mobley, Anne M. Danks
Publikováno v:
Alzheimer's & Dementia. 4
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 236(9)
We describe recent advances in the understanding of patterning in the vertebrate post-cranial mesoderm. Specifically, we discuss the integration of local information into global level information that results in the overall coordination along the ant
Publikováno v:
Developmental Dynamics; Sep2007, Vol. 236 Issue 9, p2371-2381, 11p
Autor:
Charles J. Epstein, Ryoko Takimoto-Kimura, Angela J. Villar, Weiming Xia, Pavel V. Belichenko, Bruce T. Lamb, Ralph A. Nixon, Ahmad Salehi, Gorazd B. Stokin, Janice S. Valletta, Lawrence S.B. Goldstein, Alexander M. Kleschevnikov, William A. Campbell, Kumar Sambamurti, Laura Shapiro Kulnane, William C. Mobley, Jean Dominique Delcroix, Peter Chung, Ke Zhan, Chengbiao Wu
Publikováno v:
Neuron. (1):29-42
SummaryDegeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and Ts1Cje mouse models of DS to show that the increased dose of the amyloid