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Akademický článek

Systemic treatment with a novel basic fibroblast growth factor mimic small-molecule compound boosts functional recovery after spinal cord injury.

Autor: Shiro Imagama, Ryoko Ogino, Shinya Ueno, Norihito Murayama, Naohiro Takemoto, Yoshiari Shimmyo, Taisuke Kadoshima, Shigeki Tamura, Mariko Kuroda, Yukihiro Matsuyama, Kenji Kadomatsu, Yasuhiro Morita, Teruyoshi Inoue, Naoki Ishiguro

Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0236050 (2020)

Neurotrophic factors have been regarded having promising potentials for neuronal protection and regeneration, and thus promoting beneficial effects of kinesiological functions. They can be suspected to play important roles in cell/tissue grafting for

Externí odkaz: https://doaj.org/article/b9a2abefb34d4602b1df52f9a28574d4

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Akademický článek

Metabolite profiles correlate closely with neurobehavioral function in experimental spinal cord injury in rats.

Autor: Yusuke Fujieda, Shinya Ueno, Ryoko Ogino, Mariko Kuroda, Thomas J Jönsson, Lining Guo, Takeshi Bamba, Eiichiro Fukusaki

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43152 (2012)

Traumatic spinal cord injury (SCI) results in direct physical damage and the generation of local factors contributing to secondary pathogenesis. Untargeted metabolomic profiling was used to uncover metabolic changes and to identify relationships betw

Externí odkaz: https://doaj.org/article/d354b88387854db3830541ebe3974917

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Systemic treatment with a novel basic fibroblast growth factor mimic small-molecule compound boosts functional recovery after spinal cord injury

Autor: Norihito Murayama, Naoki Ishiguro, Naohiro Takemoto, Kenji Kadomatsu, Shigeki Nara-shi Tamura, Taisuke Kadoshima, Yoshiari Shimmyo, Shinya Ueno, Yasuhiro Morita, Teruyoshi Inoue, Ryoko Ogino, Shiro Imagama, Yukihiro Matsuyama, Mariko Kuroda

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0236050 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d658c31b2d49203be77bcb430de3647f
https://doi.org/10.1371/journal.pone.0236050

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SUN11602-induced hyperexpression of calbindin D-28k is pivotal for the survival of hippocampal neurons under neurotoxic conditions

Autor: Ryoko Ogino, Nobuhiro Ueno, Yasuhiro Morita, Toyofumi Masuda, Tetsushi Oka, Teruyoshi Inoue, Shinya Ueno, Taisuke Kadoshima, Tetsuya Toba, Takafumi Noshita, Norihito Murayama, Naohiro Takemoto, Yoshiyuki Igawa, Wiebke Schulze

Publikováno v: Brain Research. 1594:71-81

Basic fibroblast growth factor (FGF-2/bFGF) possesses neuroprotective activity and promotes cell proliferation. In this study, the novel synthetic compound 4-({4-[[(4-amino-2,3,5,6-tetramethylanilino)acetyl](methyl)amino]-1-piperidinyl}methyl)benzami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c955fa82dd2f43f9a7c294da8689209
https://doi.org/10.1016/j.brainres.2014.10.066

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SUN11602 has basic fibroblast growth factor-like activity and attenuates neuronal damage and cognitive deficits in a rat model of Alzheimer׳s disease induced by amyloid β and excitatory amino acids

Autor: Nobuhiro Narii, Tetsushi Oka, Ryoko Ogino, Naohiro Takemoto, Sayaka Yoshida, Norihito Murayama, Nobuhiro Ueno, Takafumi Noshita, Teruyoshi Inoue, Tetsuya Toba

Publikováno v: Brain Research. 1585:159-166

Basic fibroblast growth factor (bFGF/FGF-2) is known to possess neuroprotective and neurite outgrowth activity properties. In this study, the effects of a novel synthetic compound that mimics the neuroprotective properties of bFGF – SUN11602 – we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83357917c09d7df158d1d40b26e58b67
https://doi.org/10.1016/j.brainres.2014.08.023

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Effect of bFGF on neuronal damage induced by sequential treatment of amyloid β and excitatory amino acid in vitro and in vivo

Autor: Shizuo Nakamura, Takafumi Noshita, Norihito Murayama, Teruyoshi Inoue, Tetsushi Oka, Ryoko Ogino

Publikováno v: European Journal of Pharmacology. 695:76-82

Effects of basic fibroblast growth factor (bFGF), a potent neurotrophin, on neuronal damage induced by sequential treatment of amyloid β (Aβ) peptide and excitatory amino acid were examined in vitro and in vivo. Treatment of rat primary cortical ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bee3236ca072b938130448206b3375c
https://doi.org/10.1016/j.ejphar.2012.09.020

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Studies of Cerebral Protective Agents. Preparation and Pharmacological Evaluation of 1-(1,4-Benzoquinon-2-yl)-1,2,3,4-tetrahydronaphthalenes as Potent Cerebral Protective Agents

Autor: Toshio Tatsuoka, Tomochika Ohno, Kenji Suzuki, K. Aisaka, Fumio Satoh, Seiji Miyano, Takafumi Ishihara, Kunihiro Sumoto, Ryoko Ogino, Manami Kuroki

Publikováno v: Chemical and Pharmaceutical Bulletin. 44:132-138

Two new series of 1-(1, 4-benzoquinon-2-yl)-1, 2, 3, 4-tetrahydronaphthalenes (3, 4) were synthesized for evaluation of their pharmacological activities. These compounds showed significant anti-lipid peroxidation (ALP) activities with rat brain homog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9053ec5c19265d60bddf51d009236980
https://doi.org/10.1248/cpb.44.132

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SUN11602, a Novel Aniline Compound, Mimics the Neuroprotective Mechanisms of Basic Fibroblast Growth Factor

Autor: Taisuke Kadoshima, Yoshiari Shimmyo, Mariko Kuroda, Ryoko Ogino, Tetsuya Toba, Norihito Murayama, Shiho Kodama, Naohiro Takemoto, Teruyoshi Inoue, Shinya Ueno, Takafumi Noshita, Tetsushi Oka, Yasuhiro Morita

Basic fibroblast growth factor (bFGF) offers some measure of protection against excitotoxic neuronal injuries by upregulating the expression of the calcium-binding protein calbindin-D28k (Calb). The newly synthesized small molecule 4-({4-[[(4-amino-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e3a249b9bf7dad203e2be0ff50e9cc
https://europepmc.org/articles/PMC3582292/