Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ryokichi Koyama"'
The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
Autor:
Yusuke Moritoh, Shin-ichi Abe, Hiroki Akiyama, Akihiro Kobayashi, Ryokichi Koyama, Ryoma Hara, Shizuo Kasai, Masanori Watanabe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Inositol hexakisphosphate kinase (IP6K) is involved in diverse cellular signalling pathways, but the physiological roles of IP6K in vivo remain unknown in mammals. Here, the authors show that the enzymatic activity of IP6K is essential for phosphate
Externí odkaz:
https://doaj.org/article/6758204230a747738df3dd582c9c832d
Publikováno v:
Molecular Pharmacology. 99:286-293
Full agonist-mediated activation of free fatty acid receptor 1 (FFAR1/GPR40) alleviates diabetes in rodents. Considering that diabetes is a chronic disease, assessment of treatment durability of chronic exposure to a GPR40 full agonist is pivotal for
Autor:
Mitsugi Ookawara, Masanori Watanabe, Ryokichi Koyama, Satoshi Sasaki, Koji Watanabe, Yusuke Moritoh
Publikováno v:
The FASEB Journal. 35
Autor:
Ryokichi Koyama, Geza Ambrus-Aikelin, Darbi Witmer, Bi-Ching Sang, Yasunori Fukuda, Hidehisa Iwata, Hideyuki Nakagawa, Masaharu Nakayama, Yusuke Kamada
Publikováno v:
ASSAY and Drug Development Technologies. 16:194-204
The retinoic acid-related orphan receptor gamma T (RORγt) plays an important role in Th17 cell proliferation and functionality. Thus, RORγt inverse agonists are thought to be potent therapeutic agents for Th17-mediated autoimmune diseases, such as
Autor:
Osamu Ujikawa, Yoko Morita, Kenichiro Shimokawa, Takayuki Hattori, Masahiro Ito, Tomoya Sameshima, Keiichiro Okuhira, Katsunori Nagai, Ikuo Fujimori, Yasuhiro Imaeda, Hiroshi Nara, Ryokichi Koyama, Mikihiko Naito, Youji Hayase, Nobuo Cho, Nobumichi Ohoka, Norihito Shibata, Osamu Sano
Publikováno v:
Journal of Biological Chemistry. 293:6776-6790
Aberrant expression of proteins often underlies many diseases, including cancer. A recently developed approach in drug development is small molecule-mediated, selective degradation of dysregulated proteins. We have devised a protein-knockdown system
Publikováno v:
Biochemical Pharmacology. 140:105-114
GPR39, a G-protein-coupled receptor activated by zinc, reportedly activates multiple intracellular signaling pathways via Gs, Gq, G12/13, and β-arrestin, but little is known about downregulation of the receptor upon its activation. To our knowledge,
Autor:
Nobumichi Ohoka, Norihito Shibata, Mikihiko Naito, Kenichiro Shimokawa, Nobuo Cho, Hiroshi Nara, Hirokazu Matsumoto, Osamu Sano, Ryokichi Koyama, Hisashi Fujita, Masahiro Ito, Katsunori Nagai, Yasuhiro Imaeda, Takayuki Hattori, Keiichiro Okuhira, Osamu Ujikawa, Mika Teratani
Publikováno v:
Journal of Biological Chemistry. 292:4556-4570
Many diseases, especially cancers, result from aberrant or overexpression of pathogenic proteins. Specific inhibitors against these proteins have shown remarkable therapeutic effects, but these are limited mainly to enzymes. An alternative approach t
Autor:
Naohiro Taya, Chien-Hung Chen, Tsuneo Oda, Bi-Ching Sang, Tomoya Yukawa, Takayuki Sato, Yoshi Nara, Noriko Uchiyama, Zenyu Shiokawa, Terufumi Takagi, Satoshi Yamamoto, Ayumu Sato, Ryokichi Koyama, Nobuyuki Negoro, Gyorgy Snell, Junya Shirai, Ryosuke Katsuyama, Takashi Imada, Yoshihiro Banno, Isaac Hoffman, Tetsuji Kawamoto, Mitsunori Kono, Robert J. Skene
Publikováno v:
Journal of medicinal chemistry. 62(3)
Retinoic acid receptor-related orphan receptor γt (RORγt) agonists are expected to provide a novel class of immune-activating anticancer drugs via activation of Th17 cells and Tc17 cells. Herein, we describe a novel structure-based functionality sw
Publikováno v:
Biochemical and biophysical research communications. 503(3)
Vasoactive intestinal peptide receptor 2 (VIPR2, also known as VPAC2) is a class B G-protein coupled receptor (GPCR) and plays important roles in the physiology of central nervous system (CNS) by interaction with natural ligands; vasoactive intestina
Autor:
Osamu Sano, Ryokichi Koyama, Osamu Ujikawa, Yoko Morita, Hiroshi Nara, Nobumichi Ohoka, Norihito Shibata, Mikihiko Naito, Takayuki Hattori, Nobuo Cho, Katsunori Nagai, Yasuhiro Imaeda
Publikováno v:
Journal of medicinal chemistry. 61(2)
Targeted protein degradation using small molecules is a novel strategy for drug development. We have developed hybrid molecules named specific and nongenetic inhibitor of apoptosis protein [IAP]-dependent protein erasers (SNIPERs) that recruit IAP ub