Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ryoichi Waki"'
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 17, Iss 1 (2014)
Purpose. This study aimed to develop a novel approach for predicting the oral absorption of low-solubility drugs by considering regional differences in solubility and permeability within the gastrointestinal (GI) tract. Methods. Simulated GI fluids w
Externí odkaz:
https://doaj.org/article/7759b5ba8beb45da918272b434f28c4e
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 15, Iss 4 (2012)
Purpose. The bile acids, phospholipids, inorganic ions, and pH in luminal fluid are very important factors for the dissolution and oral absorption of solid drugs. In this study, we evaluated the regional differences in these factors in the rat GI tra
Externí odkaz:
https://doaj.org/article/d3b18a85d8ec46f28facdf7b769d7141
Publikováno v:
Drug Metabolism and Pharmacokinetics. 28:485-490
It is well known that large differences exist in the bioavailability of orally administered drugs between species. Dissolution is the first step in the oral absorption of solid drugs. In this study, we measured the in vivo luminal concentrations of g
Autor:
Saulius Juodkazis, Takahiro Ebisui, Shigeki Matsuo, Koichi Nishimura, Tatsuya Okada, Hiroaki Misawa, Ryoichi Waki
Publikováno v:
Advanced Materials. 18:1361-1364
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 17, Iss 1 (2014)
Purpose. This study aimed to develop a novel approach for predicting the oral absorption of low-solubility drugs by considering regional differences in solubility and permeability within the gastrointestinal (GI) tract. Methods. Simulated GI fluids w
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 15, Iss 4 (2012)
Purpose. The bile acids, phospholipids, inorganic ions, and pH in luminal fluid are very important factors for the dissolution and oral absorption of solid drugs. In this study, we evaluated the regional differences in these factors in the rat GI tra