Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ryoichi Hiruma"'
Autor:
Atsushi Kamada, Ryoichi Hiruma, Motosuke Yamanaka, Masanobu Sasho, Isao Sugiyama, Akihiko Tsuruoka, Shigeto Negi, Itaru Tsukada, Kanemasa Katsu, Yuuki Komatsu, Yoshimasa Machida
Publikováno v:
ChemInform. 26
Publikováno v:
Journal of Antimicrobial Chemotherapy. 30:633-641
Three hundred and thirty-four recent clinical isolates of Pseudomonas aeruginosa were examined for susceptibility to cefclidin, cefepime, and cefpirome. Of these strains, 28.7% were resistant to ceftazidime, and 23.4% were resistant to imipenem. Abou
Publikováno v:
Journal of Antimicrobial Chemotherapy. 26:769-781
E1040 is a new parenteral cephalosporin with a broad antibacterial spectrum and potent activity against Gram-negative bacteria including Pseudomonas aeruginosa. The in-vitro activities of E1040 against clinical isolates of Enterobacter cloacae, Ent.
Autor:
Shigeto Negi, Atsushi Kamada, Ryoichi Hiruma, Motosuke Yamanaka, Akihiko Tsuruoka, Manabu Sasho, Isao Sugiyama, Yuki Komatsu, Kanemasa Katsu, Itaru Tsukada, Yoshimasa Machida
Publikováno v:
The Journal of antibiotics. 47(12)
In an effort to find a new oral cephalosporin with well-balanced antibacterial spectrum, good oral absorbability and long plasma half-life, a series of oxyimino aminothiazolyl 3-[(E)- or (Z)-N-substituted carbamoyloxy]propenyl cephems was synthesized
Autor:
Atsushi Kamada, Isao Sugiyama, Manabu Sasho, Motosuke Yamanaka, Yoshimasa Machida, Ryoichi Hiruma, Akihiko Tsuruoka, Shigeto Negi, Yuki Komatsu, Kanemasa Katsu, Itaru Tsukada
Publikováno v:
The Journal of antibiotics. 47(12)
The synthesis and antibacterial activities of 7 beta-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-N,N - dimethylcarbamoyloxymethyl-3-cephem-4-carboxylic acid (E1100) and its analogs are described, as well as oral absorbability and in vivo acti
E1077 is a novel parenteral cephalosporin with a wide spectrum of potent antibacterial activity against aerobic and anaerobic gram-positive and gram-negative bacteria. Against methicillin-susceptible Staphylococcus aureus, E1077 was twice as active a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f67c6b9858216d827e3cc398e0d66a6
https://europepmc.org/articles/PMC190561/
https://europepmc.org/articles/PMC190561/
Publikováno v:
FEBS Letters. 181:143-148
The differences in the outer membrane permeation between two major subgroups of β-lactam antibiotics were studied. The permeation of cephalosporins was closely related to porin channels in the outer membrane. In contrast, the outer membrane permeati
Publikováno v:
FEBS Letters. (2):268-272
The lipid-bilayer permeability of cephalosporins was extensively suppressed by addition of lipopolysaccharide to liposomal membrane in proportion to the hydrophobicity of the drugs. This suggests that the polysaccharide chain layer contributes to the
Publikováno v:
FEBS Letters. (2):389-392
Phospholipid bilayer permeability of β-lactam antibiotics was determined using liposomes enclosing β-lactamase. There was good correlation between the permeability and hydrophobicity within the analogous β-lactams. However, the effect of hydrophob
Publikováno v:
Reviews of infectious diseases. 10(4)
The effect of the interaction of 3-lactamase production and outer membrane permeability on the bacterial resistance to P-lactam antibiotics was investigated using the Escherichia coli K12 substrains, which have outer membrane mutation and produce TEM