Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Ryoichi Aki"'
Autor:
Ayami Hasegawa-Haruki, Koya Obara, Nanako Takaoka, Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Ryoichi Aki, Robert M Hoffman, Yasuyuki Amoh
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0304676 (2024)
Diabetes often results in chronic ulcers that fail to heal. Effective treatment for diabetic wounds has not been achieved, although stem-cell-treatment has shown promise. Hair-follicle-associated-pluripotent (HAP)-stem-cells from bulge area of mouse
Externí odkaz:
https://doaj.org/article/d3110f468ea04a87b6e216638bcddb58
Autor:
Nanako Takaoka, Michiko Yamane, Ayami Hasegawa, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Hiroyasu Hatakeyama, Yuko Hamada, Nobuko Arakawa, Manabu Tanaka, Robert M Hoffman, Yasuyuki Amoh
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0297443 (2024)
There has been only limited success to differentiate adult stem cells into cardiomyocyte subtypes. In the present study, we have successfully induced beating atrial and ventricular cardiomyocytes from rat hair-follicle-associated pluripotent (HAP) st
Externí odkaz:
https://doaj.org/article/dacbf2db30c648da89349c16824f1989
Autor:
Koya Obara, Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Ayami Hasegawa, Nanako Takaoka, Ryoichi Aki, Robert M Hoffman, Yasuyuki Amoh
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280304 (2023)
Intracerebral hemorrhage (ICH) is a leading cause of mortality with ineffective treatment. Hair-follicle-associated pluripotent (HAP) stem cells can differentiate into neurons, glial cells and many other types of cells. HAP stem cells have been shown
Externí odkaz:
https://doaj.org/article/73c86c035326486284eb87276b8b15da
Autor:
Koya Obara, Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Michiko Yamane, Nanako Takaoka, Ryoichi Aki, Robert M Hoffman, Yasuyuki Amoh
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262755 (2022)
Chronic spinal cord injury (SCI) is a highly debilitating and recalcitrant disease with limited treatment options. Although various stem cell types have shown some clinical efficacy for injury repair they have not for SCI. Hair-follicle-associated pl
Externí odkaz:
https://doaj.org/article/dcaf24e581124e8388f39dc058a9fa45
Autor:
Michiko Yamane, Nanako Takaoka, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Robert M. Hoffman, Yasuyuki Amoh
Publikováno v:
Cells, Vol 10, Iss 4, p 864 (2021)
Hair-follicle-associated pluripotent (HAP) stem cells are located in the bulge area of hair follicles from mice and humans and have been shown to differentiate to neurons, glia, keratinocytes, smooth muscle cells, melanocytes and beating cardiac musc
Externí odkaz:
https://doaj.org/article/5686ca33d11c4e5585cc53b52553e052
Autor:
Hiroyuki Kishimoto, Masashi Momiyama, Ryoichi Aki, Hiroaki Kimura, Atsushi Suetsugu, Michael Bouvet, Toshiyoshi Fujiwara, Robert M Hoffman
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79453 (2013)
Currently-used rodent tumor models, including transgenic tumor models, or subcutaneously growing tumors in mice, do not sufficiently represent clinical cancer. We report here development of methods to obtain a highly clinically-accurate rectal cancer
Externí odkaz:
https://doaj.org/article/828b04d04f04405aaa8b3579fb8d4716
Autor:
Koya Obara, Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Ayami Hasegawa, Nanao Takaoka, Ryoichi Aki, Robert M. Hoffman, Yasuyuki Amoh
BackgroundPatients frequently experience physical, mental, and even financial distress because of acute or chronic wounds to the skin. In severe situations, the skin scars can be quite noticeable, cause persistent discomfort, restrict joint motion, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abe929843eebb7324b711b2006efe20e
https://doi.org/10.21203/rs.3.rs-1931066/v1
https://doi.org/10.21203/rs.3.rs-1931066/v1
Autor:
Nanako Takaoka, Michiko Yamane, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Robert M. Hoffman, Yasuyuki Amoh
Publikováno v:
Medical molecular morphology. 55(3)
Cardiomyocytes have been differentiated from various stem cells such as human embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC), but it is difficult to produce mature cardiomyocytes. We showed rat hair-follicle-associated pluripote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f951cf1846e5ee08e4139c21a992db
https://pubmed.ncbi.nlm.nih.gov/35536435
https://pubmed.ncbi.nlm.nih.gov/35536435
Autor:
Koya Obara, Nobuko Arakawa, Yasuyuki Amoh, Yuko Hamada, Manabu Tanaka, Robert M. Hoffman, Kyoumi Shirai, Michiko Yamane, Ryoichi Aki, Nanako Takaoka
Hair-follicle-associated pluripotent (HAP) stem cells express nestin, and are located in the bulge area of hair follicles and can differentiate to numerous types of cells. In the present study, we demonstrate that rat HAP stem cells simultaneously di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24f488ae8f1c1db958f3a6c030fd8624
https://doi.org/10.21203/rs.3.rs-1001809/v1
https://doi.org/10.21203/rs.3.rs-1001809/v1
Autor:
Yasuyuki Amoh, Ryoichi Aki, Aiko Yamazaki, Nobuko Arakawa, Koya Obara, Yuko Hamada, Robert M. Hoffman, Natsuko Tohgi, Kyoumi Shirai, Shree Ram Singh
Publikováno v:
Tissue and Cell. 59:33-38
Hair-follicle-associated pluripotent (HAP) stem cells reside in the upper part of the bulge area of the the hair follicle. HAP stem cells are nestin-positive and keratin 15-negative and have the capacity to differentiate into various types of cells i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01196050f5ceb34eb15bd9c4cbbdbdd6
https://doi.org/10.1016/j.tice.2019.06.001
https://doi.org/10.1016/j.tice.2019.06.001