Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ryoichi, Kimura"'
Autor:
Rania Soudy, Ryoichi Kimura, Aarti Patel, Wen Fu, Kamaljit Kaur, David Westaway, Jing Yang, Jack Jhamandas
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/3654b8933c2a4e488728abfc7f4098ef
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
Extracellular vesicles (EVs) are double membrane structures released by all cell types with identified roles in the generation, transportation, and degradation of amyloid-β protein (Aβ) oligomers in Alzheimer’s disease (AD). EVs are thus increasi
Externí odkaz:
https://doaj.org/article/c8e10a580cea4e278ea7bc37b0f8690f
Autor:
Ryoichi Kimura, Masuo Ohno
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 2, Pp 229-235 (2009)
Although animal models of Alzheimer's disease (AD) recapitulate β-amyloid-dependent hippocampal synaptic and cognitive dysfunctions, it is poorly understood how cortex-dependent remote memory stabilization following initial hippocampal coding is aff
Externí odkaz:
https://doaj.org/article/83006d5ded0a4d8ea568c00c389968aa
Short amylin receptor antagonist peptides improve memory deficits in Alzheimer’s disease mouse model
Autor:
Aarti Patel, Jack H. Jhamandas, Ryoichi Kimura, Wen Fu, Rania Soudy, Kamaljit Kaur, David Westaway, Jing Yang
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Recent evidence supports involvement of amylin and the amylin receptor in the pathogenesis of Alzheimer’s disease (AD). We have previously shown that amylin receptor antagonist, AC253, improves spatial memory in AD mouse models. Herein, we generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1e85264f3bbf1d6c26febbc9e56711
http://link.springer.com/article/10.1038/s41598-019-47255-9
http://link.springer.com/article/10.1038/s41598-019-47255-9
Autor:
Wen Fu, Jack H. Jhamandas, Rania Soudy, Rachel A Davey, Jing Yang, Ryoichi Kimura, Jeffrey D Zajac, Aarti Patel, David Westaway, David MacTavish
Publikováno v:
Molecular Neurobiology
Based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a class B G protein-coupled receptor (GPCR), is a potential modulator of Alzheimer’s disease (AD) pathogenesis. However, past pharmacological approaches have failed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6440906649361b0bae4fb8ede6397c
https://doi.org/10.21203/rs.3.rs-515476/v1
https://doi.org/10.21203/rs.3.rs-515476/v1
Publikováno v:
Trends in Molecular Medicine. 23:709-720
Alzheimer'sdisease (AD) is a progressive neurodegenerative disorder, characterized by senile plaques constituting extracellular deposits of β-amyloid (Aβ) fibrils. Since Aβ accumulation in the brain is considered an early event preceding, by decad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b580439c8ddffbdff96dae54ae0565f
https://doi.org/10.1016/j.molmed.2017.06.003
https://doi.org/10.1016/j.molmed.2017.06.003
Autor:
Ryoichi, Kimura
Publikováno v:
理大科学フォーラム. 33(2):24-27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::a7c1eafb7b35d949df13ac777a0a973d
http://id.nii.ac.jp/1275/00003394/
http://id.nii.ac.jp/1275/00003394/
Publikováno v:
Molecular Neurobiology. 54:748-754
Accumulation of amyloid-β peptide (Aβ) is a pathological hallmark of Alzheimer’s disease (AD). We have previously demonstrated that electrophysiological and neurotoxic effects of Aβ and human amylin are expressed via the amylin receptor. Recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5838e8ecdf40c69983e359606414a760
https://doi.org/10.1007/s12035-016-9684-x
https://doi.org/10.1007/s12035-016-9684-x
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dc317075928fbf313f240629e4262b4
https://doi.org/10.1016/j.jalz.2017.06.185
https://doi.org/10.1016/j.jalz.2017.06.185
Autor:
Dharshaun Turner, Chen Wu, Jian-Xin Shen, Lu-Yao Ma, Jie Wu, Makoto Wakui, Ryoichi Kimura, Marwan Maalouf, Kevin Ellsworth
Publikováno v:
CNS Neuroscience & Therapeutics. 18:641-646
SUMMARY Aims: To evaluate the acute effects of the mitochondrial complex I inhibitor rotenone on rat hippocampal synaptic plasticity. Methods: Electrophysiological field potential recordings were used to measure basal synaptic transmission and synapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa373388d6163c87c97b5b79b499060
https://doi.org/10.1111/j.1755-5949.2012.00337.x
https://doi.org/10.1111/j.1755-5949.2012.00337.x