Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Ryohei Nakajima"'
1
Discovery of a Small-Molecule Inhibitor of β-1,6-Glucan Synthesis
Autor: Makoto Takemura, Kazuhiko Someya, Akihiro Kitamura, Ryohei Nakajima, Masato Hata
Publikováno v: Antimicrobial Agents and Chemotherapy. 53:670-677
It is possible that antifungal drugs with novel modes of action will provide favorable options to treat fungal infections. In the course of our screening for antifungal compounds acting on the cell wall, a pyridobenzimidazole derivative with unique a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c6d80374e824ba321981acee4cb305
https://doi.org/10.1128/aac.00844-08
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2
Synthesis and Antifungal Activity of Rhodopeptin Analogues. 1. Modification of the East and South Amino Acid Moieties
Autor: Ryohei Nakajima, Kazuhiko Someya, Hiroaki Inagaki, Toshiharu Ohta, Haruko C. Kawato, Kiyoshi Nakayama, Akihiro Kitamura
Publikováno v: Organic Letters. 2:973-976
Structure-activity relationships of the east and south amino acid modified analogues of rhodopeptins, novel antifungal cyclic tetrapeptides isolated from Rhodococcus species Mer-N1033, have been investigated. It was observed that a basic amino acid m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45aae350c9c0558bf623940c14a15ee8
https://doi.org/10.1021/ol005631c
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3
Oral application of romurtide, a synthetic muramyl dipeptide derivative, stimulates nonspecific resistance to microbial infections and hematopoiesis in mice
Autor: Ichiro Azuma, Kenji Namba, Ryohei Nakajima, Tsuyoshi Otani
Publikováno v: Vaccine. 14:1149-1153
Romurtide given orally enhanced the nonspecific resistance against microbial infections and hematopoiesis up to the levels achieved by subcutaneous (s.c.) injection of the compound in mice. Oral romurtide conferred protection and, in consequence, enh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8b6d465653af46951c57bd91d9fb8e
https://doi.org/10.1016/0264-410x(96)00015-1
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4
In vitro and in vivo antifungal activities of DU-6859a, a fluoroquinolone, in combination with amphotericin B and fluconazole against pathogenic fungi
Autor: M Tanaka, Ryohei Nakajima, A Kitamura, K Sato, K Someya
Publikováno v: Antimicrobial Agents and Chemotherapy. 39:1517-1521
DU-6859a is an investigational fluoroquinolone agent with potent bactericidal activity, but by itself it has no antifungal activity. When combined with amphotericin B (AmB), however, DU-6859a clearly enhanced the in vitro antifungal activity of AmB a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ea9c3a5881367b508259b326793afa
https://doi.org/10.1128/aac.39.7.1517
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8
Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of beta-1,6-glucan synthesis
Autor: Jun Watanabe, Kazuhiko Someya, Hiroshi Takeshita, Hisashi Takahashi, Akihiro Kitamura, Yoichi Kimura, Ryohei Nakajima, Makoto Takemura, Katsuhiro Kawakami
Publikováno v: Bioorganicmedicinal chemistry letters. 20(13)
Based on the HTS hit compound 1a, an inhibitor of beta-1,6-glucan synthesis, we synthesized novel pyridobenzimidazole derivatives and evaluated their antifungal activity. Among the compounds synthesized, we identified the potent compound 15e, which e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fb2bd475b75de5e618436e9a8959a0
https://pubmed.ncbi.nlm.nih.gov/20605446
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9
In vitro antifungal activities of D11-2040, a beta-1,6-glucan inhibitor, with or without currently available antifungal drugs
Autor: Ryo Okumura, Hiroshi Takeshita, Masato Hata, Akihiro Kitamura, Kazuhiko Someya, Ryohei Nakajima
Publikováno v: Biologicalpharmaceutical bulletin. 33(2)
We recently reported our discovery of small molecule beta-1,6-glucan inhibitor named D75-4590 and the anti-Candida activity of its derivatives D11-2040 and D21-6076. In this study, we further evaluated the antifungal profile of D11-2040. It alone str
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8d9f54dd069c6d6c12731764e4b37b
https://pubmed.ncbi.nlm.nih.gov/20118539
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10
Large and ultrafast photoinduced reflectivity change in the charge separated phase ofEt2Me2Sb[Pd(1,3−dithiol−2−thione−4,5−dithiolate)2]2
Autor: Eric Collet, Shin-ya Koshihara, Tadahiko Ishikawa, Maciej Lorenc, Reizo Kato, Masafumi Tamura, Ken Onda, Yoichi Okimoto, Naoto Fukazawa, Ryohei Nakajima, Yoshitaka Matsubara
Publikováno v: Physical Review B. 80
A large photoinduced change in reflectivity has been observed in the low-temperature charge separated (CS) phase of a dimeric radical anion salt, ${\text{Et}}_{2}{\text{Me}}_{2}\text{Sb}{[\text{Pd}{(\text{dmit})}_{2}]}_{2}$ ($\text{dmit}=1,3$-dithiol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::062eeccfeeab0dcae38b934182881a77
https://doi.org/10.1103/physrevb.80.115108
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