Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ryohei Furumai"'
Autor:
Kazuho Nishimura, Takuya Kumazawa, Takao Kuroda, Naohiro Katagiri, Mai Tsuchiya, Natsuka Goto, Ryohei Furumai, Akiko Murayama, Junn Yanagisawa, Keiji Kimura
Publikováno v:
Cell Reports, Vol 10, Iss 8, Pp 1310-1323 (2015)
The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress. Here, we show that the 5S RNP contributes to p53 activation and promotes cellular senescence in response
Externí odkaz:
https://doaj.org/article/069e6be3279643a59b0f5e89ca0da1da
Autor:
Masashi Kajiro, Mai Tsuchiya, Yoh-Ichi Kawabe, Ryohei Furumai, Naoya Iwasaki, Yuki Hayashi, Miyuki Katano, Yuka Nakajima, Natsuka Goto, Tatsuya Watanabe, Akiko Murayama, Hisashi Oishi, Masatsugu Ema, Satoru Takahashi, Hiroyuki Kishimoto, Junn Yanagisawa
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25871 (2011)
Protein ubiquitination is a post-translational protein modification that regulates many biological conditions. Trip12 is a HECT-type E3 ubiquitin ligase that ubiquitinates ARF and APP-BP1. However, the significance of Trip12 in vivo is largely unknow
Externí odkaz:
https://doaj.org/article/03f823a97dad474ba8cd3be68901be9c
Publikováno v:
Hum Mol Genet
UBE3A is a gene responsible for the pathogenesis of Angelman syndrome (AS), a neurodevelopmental disorder characterized by symptoms such as intellectual disability, delayed development and severe speech impairment. UBE3A encodes an E3 ubiquitin ligas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c06a07e313d0c8f7b0647f2ae272ca
https://doi.org/10.1093/hmg/ddz019
https://doi.org/10.1093/hmg/ddz019
Autor:
Norikazu Nishino, Minoru Yoshida, Akiko Saito, Kenji Ogawa, Akihiro Ito, Sueharu Horinouchi, Ryohei Furumai, Satoko Maeda
Publikováno v:
Cancer Science. 102:1081-1087
Histone deacetylase inhibitors (HDACi) have been shown to exhibit anti-inflammatory activity, but their mechanism of action is poorly understood. Trichostatin A (TSA) and the cyclic tetrapeptide class inhibitor Ky-2 inhibit both lipopolysaccharide-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea67486c1a3e5155348e408fe5dd370
https://doi.org/10.1111/j.1349-7006.2011.01904.x
https://doi.org/10.1111/j.1349-7006.2011.01904.x
Autor:
Minoru Yoshida, Kazuyo Uchida, Ken Ishigami, Soichi Kojima, Misao Yoneyama, Ryohei Furumai, Yusuke Komi, Hidenori Watanabe
Publikováno v:
Cancer Science. 101:2483-2489
Spliceostatin A (SSA) is a methylated derivative of an antitumor natural product FR901464, which specifically binds and inhibits the SF3b spliceosome sub-complex. To investigate the selective antitumor activity of SSA, we focused on the regulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc82512264187ec2dc840dac03b556b6
https://doi.org/10.1111/j.1349-7006.2010.01686.x
https://doi.org/10.1111/j.1349-7006.2010.01686.x
Autor:
Qinhong Wang, Barbara K. Goodman, Xiao-Fan Wang, Ryohei Furumai, Melanie J. Jardim, Timothy P. Wakeman
Publikováno v:
Molecular Biology of the Cell. 20:3801-3809
Genomic instability in colorectal cancer is categorized into two distinct classes: chromosome instability (CIN) and microsatellite instability (MSI). MSI is the result of mutations in the mismatch repair (MMR) machinery, whereas CIN is often thought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e727497bfd5775dc21605b484b308b5
https://doi.org/10.1091/mbc.e09-04-0303
https://doi.org/10.1091/mbc.e09-04-0303
Autor:
Zahid N. Rabbani, Michael J. Campa, Brandon A. Howard, Zeljko Vujaskovic, Xiao-Fan Wang, Ryohei Furumai, Edward F. Patz
Publikováno v:
Cancer Research. 65:8853-8860
Cyclophilin A (CypA) was recently reported to be overexpressed in non–small-cell lung cancer, and represents a potentially novel therapeutic target. To determine the role of CypA in oncogenesis, stable RNA interference (RNAi)–mediated knockdown o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07a20a5bed31b6556c69696d21971f9
https://doi.org/10.1158/0008-5472.can-05-1219
https://doi.org/10.1158/0008-5472.can-05-1219
Autor:
Ryohei Furumai, Takao Kuroda, Natsuka Goto, Mai Tsuchiya, Naohiro Katagiri, Junn Yanagisawa, Kazuho Nishimura, Takuya Kumazawa, Keiji Kimura, Akiko Murayama
Publikováno v:
Cell Reports, Vol 10, Iss 8, Pp 1310-1323 (2015)
SummaryThe 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress. Here, we show that the 5S RNP contributes to p53 activation and promotes cellular senescence in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4509194909f9a774ab65000fd367444f
https://pubmed.ncbi.nlm.nih.gov/25732822
https://pubmed.ncbi.nlm.nih.gov/25732822
Autor:
Hiromi Hiyoshi, Yuki Hayashi, Hiroyuki Kishimoto, T Morishita, Yuka Nakajima, Mai Tsuchiya, Ryohei Furumai, Junn Yanagisawa, Tsuyoshi Waku, Keiji Kimura
Publikováno v:
Oncogene. 34(35)
Many types of cancer display heterogeneity in various features, including gene expression and malignant potential. This heterogeneity is associated with drug resistance and cancer progression. Recent studies have shown that the expression of a major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf99319f4917feff38b54b852c02089
https://pubmed.ncbi.nlm.nih.gov/25435366
https://pubmed.ncbi.nlm.nih.gov/25435366
Autor:
Eiichi Araki, Minoru Yoshida, Mihoshi Suefuji, Hiroshi Oiso, Noboru Furukawa, Norikazu Nishino, Ryohei Furumai, Akihiro Ito, Seiya Shimoda, Junichi Nakagawa
Publikováno v:
Biochemical and biophysical research communications. 404(1)
Hepatic gluconeogenesis is crucial for glucose homeostasis. Although sirtuin 1 (Sirt1) is implicated in the regulation of gluconeogenesis in the liver, the effects of other histone deacetylases (HDAC) on gluconeogenesis are unclear. The aim of this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1435f3e2fbea5f021c9bbb87ce47f8
https://pubmed.ncbi.nlm.nih.gov/21108932
https://pubmed.ncbi.nlm.nih.gov/21108932