Zobrazeno 1 - 4 of 4 pro vyhledávání: '"Ryohei Fujimura"'
1
Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2)
Autor: Hiroshi Tsuneki, Yuji Matsuya, Shuichi Hirono, Hiroaki Gouda, Toshiyasu Sasaoka, Kentaro Okamoto, Ryohei Fujimura, Tsutomu Wada, Kenji Sugimoto, Naoki Toyooka, Yoshinori Ichihara
Publikováno v: European Journal of Medicinal Chemistry. 62:649-660
Novel 4-substituted 2-pyridin-2-ylamides were developed using in-silico ligand-based drug design (LBDD) in an attempt to identify inhibitors of SH2-containing 5′-inositol phosphatase 2 (SHIP2), which is implicated in insulin-resistant type 2 diabet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68694f933c8a3fd298978436e8b9d2b
https://doi.org/10.1016/j.ejmech.2013.01.014
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2
Stereoselective Total Synthesis of (-)-Batzellasides A, B, and C
Autor: Yuji Matsuya, Dejun Zhou, Kenji Sugimoto, Atsushi Kato, Ryohei Fujimura, Yasuhiro Tezuka, Toru Okaki, Daishiro Minato, Ralph A. Saporito, Masataka Sekiguchi, Isao Adachi, Naoki Toyooka
Publikováno v: European Journal of Organic Chemistry. 2013:2841-2848
Total synthesis of (–)-L-batzellasides A, B, and C has been achieved in 13 steps from known lactone 2 in 12.6, 13.2, and 13.8 % overall yields, respectively. The key steps in this synthesis were the stereoselective introduction of an allyl group at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8db0bcac5a653a6404d9ab2bb6babbd
https://doi.org/10.1002/ejoc.201201567
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