Výsledky vyhledávání - "Ryogo Hayashi"

Efficacy of TAK-457, a Novel Intravenous Triazole, against Invasive Pulmonary Aspergillosis in Neutropenic Mice

Autor: Naomi Kitamoto, Katsumi Itoh, Takashi Ichikawa, Ryogo Hayashi, Yuji Iizawa, Kenji Okonogi, Tomoyuki Kitazaki

Publikováno v: Antimicrobial Agents and Chemotherapy. 46:283-287

TAK-457 is an injectable prodrug of TAK-456, which is a novel oral triazole compound with potent antifungal activity. The in vivo efficacy of TAK-457 was evaluated in two models of invasive pulmonary aspergillosis with CDF1mice and CBA/J mice with tr

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https://doi.org/10.1128/aac.46.2.283-287.2002

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Optically Active Antifungal Azoles. XII. Synthesis and Antifungal Activity of the Water-Soluble Prodrugs of 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone

Autor: Takashi Ichikawa, Masami Yamada, Yoshihiro Matsushita, Tomoyuki Kitazaki, Kenji Okonogi, Ryogo Hayashi, Yutaka Kiyota, Masashi Yamaguchi, Katsumi Itoh

Publikováno v: Chemical and Pharmaceutical Bulletin. 49:1102-1109

1-[(1R, 2R)-2-(2, 4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (1: TAK-456) was selected as a candidate for clinical trials, but since its water-solubility was insufficient fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7635b9fdb28588c8963640464888d49a
https://doi.org/10.1248/cpb.49.1102

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Optically Active Antifungal Azoles. X. Synthesis and Antifungal Activity of N-[4-(Azolyl)phenyl]- and N-[4-(Azolylmethyl)phenyl]-N'-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-azolones

Autor: Ryogo Hayashi, Tomoyuki Kitazaki, Yoshihiro Matsushita, Kenji Okonogi, Akihiro Tasaka, Hiroshi Hosono, Takashi Ichikawa, Katsumi Itoh

Publikováno v: Chemical and Pharmaceutical Bulletin. 48:1935-1946

New optically active antifungal azoles, N-14-(azolyl)phenyl]- and N-14-(azolylmethyl)phenyl]-N'-[(IR,2R)-2(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(IH-1,2,4-triazol-1-yl)propyllazolones (1, 2, 3), were prepared in a stereocontrolled manner. Compound

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https://doi.org/10.1248/cpb.48.1935

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Optically Active Antifungal Azoles. VIII. Synthesis and Antifungal Activity of 1-((1R,2R)-2-(2,4-Difluoro- and 2-Fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-3-(4-substituted phenyl)-2(1H,3H)-imidazolones and 2-Imidazolidinones

Autor: Tomoyuki Kitazaki, Katsumi Itoh, Ryogo Hayashi, Norikazu Tamura, Hiroshi Hosono, Yoshihiro Matsushita, Kenji Okonogi, Akihiro Tasaka

Publikováno v: Chemical and Pharmaceutical Bulletin. 47:351-359

New optically active antifungal azoles, 1-[(1R,2R)-2-(2,4-difluoro- and 2-fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl ]-3-(4- substituted phenyl)-2(1H,3H)-imidazolones (1,2) and 2-imidazolidinones (3,4), were prepared in a stereo

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https://doi.org/10.1248/cpb.47.351

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Optically Active Antifungal Azoles. VI. Synthesis and Antifungal Activity of N-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-N'-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones and 5(1H,4H)-tetrazolones

Autor: Norikazu Tamura, Tomoyuki Kitazaki, Ryogo Hayashi, Katsumi Itoh, Kenji Okonogi, Yoshihiro Matsushita, Akihiro Tasaka

Publikováno v: Chemical and Pharmaceutical Bulletin. 44:314-327

A new series of optically active antifungal azoles, N-[(1R, 2R)-2-(2, 4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-N'-(4-substituted phenyl)-3(2H, 4H)-1, 2, 4-triazolones (1, 2) and 5(1H, 4H)-tetrazolones (3), were prepared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e34390bb3a6cde8012ae5185666a9f
https://doi.org/10.1248/cpb.44.314

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Enterococcus faecalis aggravates pyelonephritis caused by Pseudomonas aeruginosa in experimental ascending mixed urinary tract infection in mice

Autor: Toshiyuki Yamazaki, K Okonogi, N Tsuchimori, Ryogo Hayashi, A Shino

Publikováno v: Infection and Immunity. 62:4534-4541

Mixed urinary tract infection was caused by simultaneous inoculation of 10(4) CFU each of Enterococcus faecalis TN2005 and Pseudomonas aeruginosa P9 into the bladders of CBA/J mice. Both organisms proliferated in the kidneys, and viable cell counts o

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https://doi.org/10.1128/iai.62.10.4534-4541.1994

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Optically Active Antifungal Azoles. II. Synthesis and Antifungal Activity of Polysulfide Derivatives of (2R,3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Autor: Katsumi Itoh, Kenji Okonogi, Akihiro Tasaka, Yoshihiro Matsushita, Norikazu Tamura, Ryogo Hayashi, Katsunori Teranishi

Publikováno v: Chemical and Pharmaceutical Bulletin. 41:1043-1048

In an effort to find potent antifungal agents, a variety of optically active triazole derivatives with a polysulfide structure, 3, 4 and 5, were prepared and evaluated for antifungal activity against Candida albicans in vitro and in vivo. The symmetr

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https://doi.org/10.1248/cpb.41.1043

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Therapeutic effect of cefozopran (SCE-2787), a new parenteral cephalosporin, against experimental infections in mice

Autor: Akira Imada, Ryogo Hayashi, Kenji Okonogi, Toshiyuki Yamazaki, Yuji Iizawa, Tomoyuki Iwahi

Publikováno v: Antimicrobial Agents and Chemotherapy. 37:100-105

The therapeutic effect of cefozopran (SCE-2787), a new semisynthetic parenteral cephalosporin, against experimental infections in mice was examined. Cefozopran was more effective than cefpiramide and was as effective as ceftazidime and cefpirome agai

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https://doi.org/10.1128/aac.37.1.100

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Optically Active Antifungal Azoles. I. Synthesis and Antifungal Activity of (2R,3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol and Its Stereoisomers

Autor: Katsunori Teranishi, Norikazu Tamura, Katsumi Itoh, Yoshihiro Matsushita, Kenji Okonogi, Ryogo Hayashi, Akihiro Tasaka

Publikováno v: Chemical and Pharmaceutical Bulletin. 41:1035-1042

(2R,3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl )-2-butano l [(2R,3R)-7] and its stereoisomers [(2S,3R)-, (2S,3S)- and (2R,3S)-7] were prepared from the optically active oxiranes 6 by a newly developed ring-opening reaction and eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdacbc4c7ad90feb1f7414e1321fc601
https://doi.org/10.1248/cpb.41.1035

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