Výsledky vyhledávání

Akademický článek

TSPAN2 Is Involved in Cell Invasion and Motility during Lung Cancer Progression

Autor: Chihiro Otsubo, Ryo Otomo, Makoto Miyazaki, Yuko Matsushima-Hibiya, Takashi Kohno, Reika Iwakawa, Fumitaka Takeshita, Hirokazu Okayama, Hitoshi Ichikawa, Hideyuki Saya, Tohru Kiyono, Takahiro Ochiya, Fumio Tashiro, Hitoshi Nakagama, Jun Yokota, Masato Enari

Publikováno v: Cell Reports, Vol 7, Iss 2, Pp 527-538 (2014)

Summary: In lung cancer progression, p53 mutations are more often observed in invasive tumors than in noninvasive tumors, suggesting that p53 is involved in tumor invasion and metastasis. To understand the nature of p53 function as a tumor suppressor

Externí odkaz: https://doaj.org/article/e73b97deeab04def8cdc0bfcc1c5e983

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Plasma Xanthine Oxidoreductase Activity is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population

Autor: Fumitaka Tanaka, Kiyomi Sakata, Ryo Otomo, Takahito Nasu, Satoru Taguchi, Jiro Hitomi, Kenji Sobue, Yuka Kotozaki, Hiroto Kikuchi, Atsushi Shimizu, Makoto Sasaki, Kozo Tanno, Mamoru Satoh, Hideki Ohmomo, Takamasa Kobayashi

Publikováno v: International Journal of Environmental Research and Public Health, Vol 18, Iss 1894, p 1894 (2021)
International Journal of Environmental Research and Public Health
Volume 18
Issue 4

The purpose of this study was to investigate the association between xanthine oxidoreductase (XOR) activity and a high risk of cardiovascular disease (CVD) in a general Japanese population. The Iwate Tohoku Medical Megabank Organization pooled indivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eba1c737af33356919b16c127f57488
https://www.mdpi.com/1660-4601/18/4/1894

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Akademický článek

DNA Methylation Abnormalities and Altered Whole Transcriptome Profiles after Switching from Combustible Tobacco Smoking to Heated Tobacco Products.

Autor: Hideki Ohmomo, Sei Harada, Shohei Komaki, Kanako Ono, Yoichi Sutoh, Ryo Otomo, So Umekage, Tsuyoshi Hachiya, Kota Katanoda, Toru Takebayashi, Atsushi Shimizu

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention; Jan2022, Vol. 31 Issue 1, p269-279, 11p

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Abstract P031: Plasma Xanthine Oxidoreductase Activity is Associated With Edothelial Dysfucntion and Increased Arterial Stiffness in a General Japanese Population: the Iwate Tohoku Medical Megabank Project

Autor: Mamoru Satoh, Fumitaka Tanaka, Kiyomi Sakata, Jiro Hitomi, Kozo Tanno, Ryo Otomo, Makoto Sasaki, Yuka Kotozaki, Hideki Ohmomo, Atsushi Shimizu

Publikováno v: Circulation. 139

An increase in xanthine oxidoreductase (XOR) activity is related to various diseases such as diabetes, hypertension and obesity has been reported. However, so far the association with XOR activity and pathogenesis of atherosclerosis in a general Japa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9801fd1b2b8f0594a7a40374645dc79a
https://doi.org/10.1161/circ.139.suppl_1.p031

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The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas

Autor: Takahiro Ochiya, Ryuichi Sakai, Naomi Abe, Arata Tomiyama, Koichi Ichimura, Ryo Otomo, Masato Enari, Makoto Miyazaki, Hitoshi Nakagama, Hidenobu Suzuki, Koichi Matsuda, Toshiki Watanabe, Ayana Nakajima, Yuko Matsushima-Hibiya

Publikováno v: Cell Death Discovery, Vol 4, Iss 1, Pp 1-17 (2018)
Cell Death Discovery

Anaplastic lymphoma kinase (ALK) is an oncogenic receptor tyrosine kinase that is activated by gene amplification and mutation in neuroblastomas. ALK inhibitors can delay the progression of ALK-driven cancers, but are of limited use owing to ALK inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b112faeed47dd51951f5d28b1320cb
https://doi.org/10.1038/s41420-018-0059-0

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iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation

Autor: Ryo Otomo, Yuh Shiwa, Shohei Komaki, Hideki Ohmomo, Kenji Sobue, Makoto Sasaki, Tsuyoshi Hachiya, Ryohei Furukawa, Jiro Hitomi, Mamoru Satoh, Atsushi Shimizu

Publikováno v: Human Genome Variation

We launched an integrative multi-omics database, iMETHYL (http://imethyl.iwate-megabank.org). iMETHYL provides whole-DNA methylation (~24 million autosomal CpG sites), whole-genome (~9 million single-nucleotide variants), and whole-transcriptome (>14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42707c97f941b1cd1f830b4b75aff282
https://doi.org/10.1038/hgv.2018.8

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Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS)

Autor: Makoto Miyazaki, Ryo Otomo, Yuko Matsushima-Hibiya, Masato Enari

Publikováno v: Methods in Molecular Biology ISBN: 9781493969531

Ataxia-telangiectasia mutated (ATM) protein is a member of the phosphatidylinositol 3-phosphate kinase (PI3-K)-related protein kinase (PIKK) family and is implicated in the initiation of signaling pathways following DNA double strand breaks (DSBs) el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28aefe82bb03121dd6dc5e08197a8c8a
https://doi.org/10.1007/978-1-4939-6955-5_11

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