Single cell analysis revealed that two distinct, unique CD4+ T cell subsets were increased in the small intestinal intraepithelial lymphocytes of aged mice

Autor: Yuki Yonemoto, Yasuhiro Nemoto, Ryo Morikawa, Nana Shibayama, Shigeru Oshima, Takashi Nagaishi, Tomohiro Mizutani, Go Ito, Satoru Fujii, Ryuichi Okamoto

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Recent advances in research suggest that aging has a controllable chronic inflammatory disease aspect. Aging systemic T cells, which secrete pro-inflammatory factors, affect surrounding somatic cells, and accelerate the aging process through chronic

Externí odkaz: https://doaj.org/article/eabcaa9857894d08ba028fb74b77537c

Polymorphisms in the hypoxia inducible factor binding site of the macrophage migration inhibitory factor gene promoter in schizophrenia.

Autor: Satoshi Okazaki, Shuken Boku, Yuichiro Watanabe, Ikuo Otsuka, Tadasu Horai, Ryo Morikawa, Atsushi Kimura, Naofumi Shimmyo, Takaki Tanifuji, Toshiyuki Someya, Akitoyo Hishimoto

Publikováno v: PLoS ONE, Vol 17, Iss 3, p e0265738 (2022)

BackgroundMacrophage migration inhibitory factor (MIF) is a multifunctional cytokine that promotes neurogenesis and neuroprotection. MIF is predominantly expressed in astrocytes in the brain. The serum MIF level and microsatellites/single nucleotide

Externí odkaz: https://doaj.org/article/e3b8d20e652343bd816168d7a3768297

Chemotherapy and COVID-19 Vaccination in Patients With Gastrointestinal Cancer.

Autor: MITSUKUNI SUENAGA, SHINICHI YAMAUCHI, RYO MORIKAWA, RIKA NOJI, YOSHIHITO KANO, MASANORI TOKUNAGA, YUSUKE KINUGASA

Publikováno v: In Vivo; May/Jun2024, Vol. 38 Issue 3, p1278-1284, 7p

Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal

Autor: Tetsuya Nakamura, Kengo Nozaki, Takashi Nagaishi, Shohei Tanaka, Mamoru Watanabe, Shigeru Oshima, Ryuichi Okamoto, Yasuhiro Nemoto, Kiichiro Tsuchiya, Yuria Takei, Ryo Morikawa, Yuki Yonemoto, Tomohiro Mizutani

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1483-1503 (2021)

Background & Aims The reason why small intestinal cancer is rarer than colorectal cancer is not clear. We hypothesized that intraepithelial lymphocytes (IELs), which are enriched in the small intestine, are the closest immune cells to epithelial cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67aa00d8964ae2eaf28a3670cd13d6cf
https://doi.org/10.1016/j.jcmgh.2021.01.014

High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage

Autor: Ryo Morikawa, Ryuichi Okamoto, Shohei Tanaka, Shigeru Oshima, Yuria Takei, Takashi Nagaishi, Yasuhiro Nemoto, Susanne Stutte, Kiichiro Tsuchiya, Mamoru Watanabe, Tetsuya Nakamura

Publikováno v: Biochemical and Biophysical Research Communications. 522:971-977

In Japan and other Asian countries, increased fat uptake induced by a westernized diet is thought to be associated with an increased incidence of inflammatory bowel disease, colorectal cancer and food allergies; however, the mechanism for this remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968584c4a455dea04ad9d1b84817e0cc
https://doi.org/10.1016/j.bbrc.2019.11.158