Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Ryo Kurita"'
Autor:
Jing Liang, Yang Wan, Jie Gao, Lingyue Zheng, Jingwei Wang, Peng Wu, Yue Li, Bingrui Wang, Ding Wang, Yige Ma, Biao Shen, Xue Lv, Di Wang, Na An, Xiaoli Ma, Guangfeng Geng, Jingyuan Tong, Jinhua Liu, Guo Chen, Meng Gao, Ryo Kurita, Yukio Nakamura, Ping Zhu, Hang Yin, Xiaofan Zhu, Lihong Shi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Inherited non-hemolytic anemia is a group of rare bone marrow disorders characterized by erythroid defects. Although concerted efforts have been made to explore the underlying pathogenetic mechanisms of these diseases, the understanding of t
Externí odkaz:
https://doaj.org/article/ca931a4b72104298b6b0e6cd651f9da0
Autor:
Kirti Prasad, Nivedhitha Devaraju, Anila George, Nithin Sam Ravi, Joshua Paul, Gokulnath Mahalingam, Vignesh Rajendiran, Lokesh Panigrahi, Vigneshwaran Venkatesan, Kartik Lakhotiya, Yogapriya Periyasami, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Shaji R. Velayudhan, Gregory A. Newby, Srujan Marepally, Alok Srivastava, Kumarasamypet M. Mohankumar
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102205- (2024)
β-thalassemia/HbE results from mutations in the β-globin locus that impede the production of functional adult hemoglobin. Base editors (BEs) could facilitate the correction of the point mutations with minimal or no indel creation, but its efficienc
Externí odkaz:
https://doaj.org/article/1c5f0f013cfe4f2da711f4e85aae51fa
Autor:
Vigneshwaran Venkatesan, Abisha Crystal Christopher, Manuel Rhiel, Manoj Kumar K. Azhagiri, Prathibha Babu, Kaivalya Walavalkar, Bharath Saravanan, Geoffroy Andrieux, Sumathi Rangaraj, Saranya Srinivasan, Karthik V. Karuppusamy, Annlin Jacob, Abhirup Bagchi, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Rekha Pai, Srujan Kumar Marepally, Kumarasamypet Murugesan Mohankumar, Shaji R. Velayudhan, Melanie Boerries, Dimple Notani, Toni Cathomen, Alok Srivastava, Saravanabhavan Thangavel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 671-688 (2023)
Reactivation of fetal hemoglobin (HbF) is a commonly adapted strategy to ameliorate β-hemoglobinopathies. However, the continued production of defective adult hemoglobin (HbA) limits HbF tetramer production affecting the therapeutic benefits. Here,
Externí odkaz:
https://doaj.org/article/444686798a7c40d7a355be2ff089b162
Autor:
Deborah E. Daniels, Damien J. Downes, Ivan Ferrer-Vicens, Daniel C. J. Ferguson, Belinda K. Singleton, Marieangela C. Wilson, Kongtana Trakarnsanga, Ryo Kurita, Yukio Nakamura, David J. Anstee, Jan Frayne
Publikováno v:
Haematologica, Vol 109, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/4d782518f626402dbd7d20dbf0bff7ad
Autor:
Nikoletta Y. Papaioannou, Petros Patsali, Basma Naiisseh, Panayiota L. Papasavva, Lola Koniali, Ryo Kurita, Yukio Nakamura, Soteroula Christou, Maria Sitarou, Claudio Mussolino, Toni Cathomen, Marina Kleanthous, Carsten W. Lederer
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Introduction: Genome editing tools, such as CRISPR/Cas, TALE nucleases and, more recently, double-strand-break-independent editors, have been successfully used for gene therapy and reverse genetics. Among various challenges in the field, tolerable an
Externí odkaz:
https://doaj.org/article/0fbfbdfb3fde4f0eb2824e45f9241f24
Autor:
Bingrui Wang, Chenchen Wang, Yang Wan, Jie Gao, Yige Ma, Yingnan Zhang, Jingyuan Tong, Yingchi Zhang, Jinhua Liu, Lixian Chang, Changlu Xu, Biao Shen, Yumei Chen, Erlie Jiang, Ryo Kurita, Yukio Nakamura, Kim-Chew Lim, James Douglas Engel, Jiaxi Zhou, Tao Cheng, Xiaofan Zhu, Ping Zhu, Lihong Shi
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-19 (2022)
Abstract Ribosomal protein dysfunction causes diverse human diseases, including Diamond–Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, which are characterized by tissue-
Externí odkaz:
https://doaj.org/article/9b5ff8adcf4941ae8efd9d63a2f23084
Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2
Autor:
Anila George, Nithin Sam Ravi, Kirti Prasad, Lokesh Panigrahi, Sanya Koikkara, Vignesh Rajendiran, Nivedhitha Devaraju, Joshua Paul, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R. Velayudhan, Alok Srivastava, Kumarasamypet M. Mohankumar
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
Sickle cell anaemia (SCA) is one of the common autosomal recessive monogenic disorders, caused by a transverse point mutation (GAG > GTG) at the sixth codon of the beta-globin gene, which results in haemolytic anaemia due to the fragile RBCs. Recent
Externí odkaz:
https://doaj.org/article/5c7fcda3597440939586146c2d46906f
Autor:
Noemy Piantanida, Marta La Vecchia, Marika Sculco, Maria Talmon, Gioele Palattella, Ryo Kurita, Yukio Nakamura, Antonella Ellena Ronchi, Irma Dianzani, Steven R. Ellis, Luigia Grazia Fresu, Anna Aspesi
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Introduction: Diamond Blackfan anemia (DBA) is a rare congenital disease characterized by defective maturation of the erythroid progenitors in the bone marrow, for which treatment involves steroids, chronic transfusions, or hematopoietic stem cells t
Externí odkaz:
https://doaj.org/article/a40a9bae10f047e9b5898d2bc47dbcb9
Autor:
Deborah E. Daniels, Daniel C.J. Ferguson, Rebecca E. Griffiths, Kongtana Trakarnsanga, Nicola Cogan, Katherine A. MacInnes, Kathryn E. Mordue, Tatyana Andrienko, Ivan Ferrer-Vicens, Daniel Ramos Jiménez, Phillip A. Lewis, Marieangela C. Wilson, Maurice A. Canham, Ryo Kurita, Yukio Nakamura, David J. Anstee, Jan Frayne
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 26-39 (2021)
Developing robust methodology for the sustainable production of red blood cells in vitro is essential for providing an alternative source of clinical-quality blood, particularly for individuals with rare blood group phenotypes. Immortalized erythroid
Externí odkaz:
https://doaj.org/article/1be556ed511b484ca9104a2782e6751a
Autor:
Svetlana Soboleva, Ryo Kurita, Fredrik Ek, Hugo Åkerstrand, Rita Silvério-Alves, Roger Olsson, Yukio Nakamura, Kenichi Miharada
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
In an imaging-based screen of >3,300 compounds compounds, Soboleva et al identify HDAC inhibitors as mediators of erythroid cell enucleation. They further show that the erythroid-specific cell membrane protein, SPTA1, is downregulated in HDAC inhibit
Externí odkaz:
https://doaj.org/article/61f572de14eb48a18df29210fe97c443