Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Ryo Kominami"'
Autor:
Hiroyuki Abe, Kenya Kamimura, Shujiro Okuda, Yu Watanabe, Jun Inoue, Yutaka Aoyagi, Toshifumi Wakai, Ryo Kominami, Shuji Terai
Publikováno v:
Cancer Medicine, Vol 12, Iss 14, Pp 15650-15663 (2023)
Abstract Introduction B‐cell lymphoma/leukemia 11B (BCL11B) is a subunit of SWI/SNF chromatin remodeling complexes and functions in cell cycle regulation and apoptosis upon DNA replication stress and damages via transcription. Many malignancies wer
Externí odkaz:
https://doaj.org/article/b28136d80b664370b096168307a180cc
Autor:
Shumpei P. Yasuda, Yuki Miyasaka, Xuehan Hou, Yo Obara, Hiroshi Shitara, Yuta Seki, Kunie Matsuoka, Ai Takahashi, Eri Wakai, Hiroshi Hibino, Toyoyuki Takada, Toshihiko Shiroishi, Ryo Kominami, Yoshiaki Kikkawa
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2221 (2022)
An MSM/Ms strain was established using Japanese wild mice, which exhibit resistance to several phenotypes associated with aging, such as obesity, inflammation, and tumorigenesis, compared to common inbred mouse strains. MSM/Ms strain is resistant to
Externí odkaz:
https://doaj.org/article/b75c825ab039479b8e28c8ba546586f6
Autor:
Satoshi Kojo, Hirokazu Tanaka, Takaho A. Endo, Sawako Muroi, Ye Liu, Wooseok Seo, Mari Tenno, Kiyokazu Kakugawa, Yoshinori Naoe, Krutula Nair, Kazuyo Moro, Yoshinori Katsuragi, Akinori Kanai, Toshiya Inaba, Takeshi Egawa, Byrappa Venkatesh, Aki Minoda, Ryo Kominami, Ichiro Taniuchi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper expre
Externí odkaz:
https://doaj.org/article/0177c41482984628992633de17614903
Autor:
Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yoshimasa Aoto, Tsuyoshi Hachiya, Yasubumi Sakakibara, Yoshinori Katsuragi, Satoshi Hirose, Ryo Kominami, Ryo Goitsuka, Takuro Nakamura, Yuichi Wakabayashi
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102111 (2014)
Previous studies have shown that Meis1 plays an important role in blood development and vascular homeostasis, and can induce blood cancers, such as leukemia. However, its role in epithelia remains largely unknown. Here, we uncover two roles for Meis1
Externí odkaz:
https://doaj.org/article/1ee8ffa80179424789347212c892310d
Autor:
Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Ikuo Miura, Shigeharu Wakana, Ryo Kominami, Yuichi Wakabayashi
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97201 (2014)
Genome-wide association studies have revealed that many low-penetrance cancer susceptibility loci are located throughout the genome; however, a very limited number of genes have been identified so far. Using a forward genetics approach to map such lo
Externí odkaz:
https://doaj.org/article/ff5384b94a8949348963da849b1190d2
Autor:
Kazuhiro Okumura, Takehiko Kamijo, Koichi Matsuda, Ryo Kominami, Eriko Isogai, Kimi Araki, Megumi Saito, Yuichi Wakabayashi, Chizu Tanikawa
Publikováno v:
Journal of Investigative Dermatology. 139:1459-1469
Identification of the specific genetic variants responsible for the increased susceptibility to familial or sporadic cancers is important. Using a forward genetics approach to map such loci in a mouse skin cancer model, we previously identified a str
Autor:
Ichiro Taniuchi, Yoshinori Naoe, Yoshinori Katsuragi, Mari Tenno, Sawako Muroi, Ye Liu, Aki Minoda, Satoshi Kojo, Kazuyo Moro, Takeshi Egawa, Takaho A. Endo, Hirokazu Tanaka, Akinori Kanai, Kiyokazu Kakugawa, Toshiya Inaba, Byrappa Venkatesh, Ryo Kominami, Krutula Nair, Wooseok Seo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications
T-lineage committed precursor thymocytes are screened by a fate-determination process mediated via T cell receptor (TCR) signals for differentiation into distinct lineages. However, it remains unclear whether any antecedent event is required to coupl
Autor:
Midori Yamaguchi, Hiroshi Shitara, Kazuhiro Okumura, Ryo Kominami, Eriko Isogai, Yuichi Wakabayashi, Ikuo Miura, Megumi Saito, Andrew C. Karaplis, Choji Taya, Shigeharu Wakana, Haruka Munakata, Yasuhiro Yoshizawa
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Using a forward genetics approach to map loci in a mouse skin cancer model, we previously identified a genetic locus, Skin tumour modifier of MSM 1 (Stmm1) on chromosome 7, conferring strong tumour resistance. Sub-congenic mapping localized Parathyro
Autor:
Megumi, Saito, Kazuhiro, Okumura, Eriko, Isogai, Kimi, Araki, Chizu, Tanikawa, Koichi, Matsuda, Takehiko, Kamijo, Ryo, Kominami, Yuichi, Wakabayashi
Publikováno v:
The Journal of investigative dermatology. 139(7)
Identification of the specific genetic variants responsible for the increased susceptibility to familial or sporadic cancers is important. Using a forward genetics approach to map such loci in a mouse skin cancer model, we previously identified a str
Autor:
Miki Obata, Yukio Mishima, Kensuke Otsuka, Yoshiyuki Sakuraba, Masako Ochiai, Manabu Abe, Yoichi Gondo, Tomohiro Iwasaki, Yutaka Aoyagi, Kenji Sakimura, Toshihiro Sato, Akira Sakamaki, Yoshinori Katsuragi, Ryo Kominami, Hitoshi Nakagama, Masanori Tomita
Publikováno v:
Carcinogenesis. 36:622-631
SWI/SNF chromatin remodeling complexes constitute a highly related family of multi-subunit complexes to modulate transcription, and SWI/SNF subunit genes are collectively mutated in 20% of all human cancers. Bcl11b is a SWI/SNF subunit and acts as a