Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Ryo Hotta"'
Autor:
Weikang Pan, Ahmed A. Rahman, Takahiro Ohkura, Rhian Stavely, Kensuke Ohishi, Christopher Y. Han, Abigail Leavitt, Aki Kashiwagi, Alan J. Burns, Allan M. Goldstein, Ryo Hotta
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Neurointestinal diseases cause significant morbidity and effective treatments are lacking. This study aimes to test the feasibility of transplanting autologous enteric neural stem cells (ENSCs) to rescue the enteric nervous system (ENS) in a
Externí odkaz:
https://doaj.org/article/a79ce412a55e45d297b62f324b8dce20
Autor:
Ahmed A. Rahman, Rhian Stavely, Weikang Pan, Leah Ott, Kensuke Ohishi, Takahiro Ohkura, Christopher Han, Ryo Hotta, Allan M. Goldstein
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 907-921 (2024)
Background & Aims: Intestinal inflammation is associated with loss of enteric cholinergic neurons. Given the systemic anti-inflammatory role of cholinergic innervation, we hypothesized that enteric cholinergic neurons similarly possess anti-inflammat
Externí odkaz:
https://doaj.org/article/9f96d67dcc0845259cc01b9f26ac6f70
Autor:
Ryo Hotta, Ahmed Rahman, Sukhada Bhave, Rhian Stavely, Weikang Pan, Shriya Srinivasan, Geoffrey de Couto, Luis Rodriguez-Borlado, Richard Myers, Alan J. Burns, Allan M. Goldstein
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background Enteric neuropathies, which result from abnormalities of the enteric nervous system, are associated with significant morbidity and high health-care costs, but current treatments are unsatisfactory. Cell-based therapy offers an inn
Externí odkaz:
https://doaj.org/article/3507b616264b4da0a5ab836cf0ab4178
Autor:
Richard A. Guyer, Nicole Picard, Jessica L. Mueller, Kensuke Ohishi, Abigail Leavitt, Andrew J. Murphy, Kristine M. Cornejo, Ryo Hotta, Allan M. Goldstein
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/4c7a37fb29a5493388583857495fd4f6
Autor:
Ryo Hotta, Weikang Pan, Sukhada Bhave, Nandor Nagy, Rhian Stavely, Takahiro Ohkura, Kumar Krishnan, Geoffrey de Couto, Richard Myers, Luis Rodriguez-Borlado, Alan J. Burns, Allan M. Goldstein
Publikováno v:
Cell Transplantation, Vol 32 (2023)
The enteric nervous system (ENS) is an extensive network of neurons and glia within the wall of the gastrointestinal (GI) tract that regulates many essential GI functions. Consequently, disorders of the ENS due to developmental defects, inflammation,
Externí odkaz:
https://doaj.org/article/2be94383c769473181d73fdc2d28dfb1
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 229 (2024)
Neurointestinal diseases represent a significant challenge in clinical management with current palliative approaches failing to overcome disease and treatment-related morbidity. The recent progress with cell therapy to restore missing or defective co
Externí odkaz:
https://doaj.org/article/0bda0ee17c174098b16f7b99df051f14
Autor:
Richard A. Guyer, Rhian Stavely, Keiramarie Robertson, Sukhada Bhave, Jessica L. Mueller, Nicole M. Picard, Ryo Hotta, Julia A. Kaltschmidt, Allan M. Goldstein
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112194- (2023)
Summary: The enteric nervous system (ENS) consists of glial cells (EGCs) and neurons derived from neural crest precursors. EGCs retain capacity for large-scale neurogenesis in culture, and in vivo lineage tracing has identified neurons derived from g
Externí odkaz:
https://doaj.org/article/341cb57d221b46b58225294c16e22a7f
Autor:
Timna Inlender, Einat Nissim-Eliraz, Rhian Stavely, Ryo Hotta, Allan M. Goldstein, Simcha Yagel, Michael J. Gutnick, Nahum Y. Shpigel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract In mammals, neural crest cells populate the gut and form the enteric nervous system (ENS) early in embryogenesis. Although the basic ENS structure is highly conserved across species, we show important differences between mice and humans rela
Externí odkaz:
https://doaj.org/article/5abeb2169b57401aa332f2c1e53eb7db
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Hirschsprung disease is most often characterized by aganglionosis limited to the distal colon and rectum, and mice lacking the Endothelin receptor type B (Ednrb) faithfully recapitulate this phenotype. However, despite the presence of enteric ganglia
Externí odkaz:
https://doaj.org/article/46c62c5e0999406d88eda6d6d13d4a4c
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
With a steadily aging population there is an increasing prevalence of neurological disorders. Given the lack of effective treatment strategies and a limited ability for the central nervous system (CNS) to regenerate endogenously, there is a critical
Externí odkaz:
https://doaj.org/article/ad65859861d049ecbc9b300887520757