Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Ryo Fukuyama"'
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28835- (2024)
Nattokinase (NK), also known as subtilisin NAT (EC 3.4.21.62), is a serine protease produced by Bacillus subtilis natto that has anti-inflammatory and fibrinolytic properties. To study whether NK prevents the progression of pathological changes in di
Externí odkaz:
https://doaj.org/article/3ae81ef3f1db4e9b94c01f47e08a8c87
Autor:
Takeshi Moriishi, Ryosuke Ozasa, Takuya Ishimoto, Takayoshi Nakano, Tomoka Hasegawa, Toshihiro Miyazaki, Wenguang Liu, Ryo Fukuyama, Yuying Wang, Hisato Komori, Xin Qin, Norio Amizuka, Toshihisa Komori
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008586 (2020)
The strength of bone depends on bone quantity and quality. Osteocalcin (Ocn) is the most abundant noncollagenous protein in bone and is produced by osteoblasts. It has been previously claimed that Ocn inhibits bone formation and also functions as a h
Externí odkaz:
https://doaj.org/article/d5d0f81ee72f41168d49071142fbdb22
Autor:
Ryo Fukuyama, Akio Shimokawa, Yasushi Kodama, Mitsugu Fujita, Yoshitaka Ohishi, Yuko Ando, Masao Koida, Hiromichi Nakamuta
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 2, Pp 214-220 (2011)
Abstract.: The benzo[b]furan derivative MU314 inhibits in vitro bone resorption as potently as β-estradiol (E2). Here, we examined the point of action on the anti-osteoporotic effects of MU314. MU314 (10 nM) suppressed lacunae formation by osteoclas
Externí odkaz:
https://doaj.org/article/9a65eb77bf734b59b6c8d17972d2ac6d
Autor:
Takeshi Moriishi, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Takafumi Maeno, Yosuke Kawai, Hisato Komori, Toshihisa Komori
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40143 (2012)
Reduced mechanical stress is a major cause of osteoporosis in the elderly, and the osteocyte network, which comprises a communication system through processes and canaliculi throughout bone, is thought to be a mechanosensor and mechanotransduction sy
Externí odkaz:
https://doaj.org/article/73231feae0de4ce2bde6f53ff982fca7
Autor:
Carolina A Yoshida, Hisato Komori, Zenjiro Maruyama, Toshihiro Miyazaki, Keishi Kawasaki, Tatsuya Furuichi, Ryo Fukuyama, Masako Mori, Kei Yamana, Kouhei Nakamura, Wenguang Liu, Satoru Toyosawa, Takeshi Moriishi, Hiroshi Kawaguchi, Kenji Takada, Toshihisa Komori
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32364 (2012)
RUNX2 and SP7 are essential transcription factors for osteoblast differentiation at an early stage. Although RUNX2 inhibits osteoblast differentiation at a late stage, the function of SP7 at the late stage of osteoblast differentiation is not fully e
Externí odkaz:
https://doaj.org/article/e639d011c37e43edae07c19f4d69c22e
Autor:
Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komori
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27487 (2011)
Bcl2 subfamily proteins, including Bcl2 and Bcl-X(L), inhibit apoptosis. As osteoblast apoptosis is in part responsible for osteoporosis in sex steroid deficiency, glucocorticoid excess, and aging, bone loss might be inhibited by the upregulation of
Externí odkaz:
https://doaj.org/article/2a5a87095d354acfbb744dbee1880200
Publikováno v:
Journal of the Japan Society for Precision Engineering. 88:345-351
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63de54afe8bc600fe064f601ef9dac46
https://doi.org/10.2493/jjspe.88.345
https://doi.org/10.2493/jjspe.88.345
Autor:
Takeshi, Moriishi, Takuro, Ito, Ryo, Fukuyama, Xin, Qin, Hisato, Komori, Hitomi, Kaneko, Yuki, Matsuo, Noriaki, Yoshida, Toshihisa, Komori
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 3173
The relationship of lacunocanalicular network structure and mechanoresponse has not been well studied. The lacunocanalicular structures differed in the compression and tension sides, in the regions, and in genders in wild-type femoral cortical bone.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3accb28a7c8077922b998779d86447
https://doi.org/10.3390/ijms23063173
https://doi.org/10.3390/ijms23063173
Autor:
Takayoshi Nakano, Toshihiro Miyazaki, Norio Amizuka, Hisato Komori, Ryosuke Ozasa, Wenguang Liu, Takuya Ishimoto, Tomoka Hasegawa, Ryo Fukuyama, Yuying Wang, Xin Qin, Takeshi Moriishi, Toshihisa Komori
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008586 (2020)
Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass. Takeshi Moriishi et al. PLOS Genetics. 2020. 5(28)doi.org/10.1371/journal.pgen.1008586
The strength of bone d
The strength of bone d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927357de183098c187bf2faa5dc880a4
https://doaj.org/article/d5d0f81ee72f41168d49071142fbdb22
https://doaj.org/article/d5d0f81ee72f41168d49071142fbdb22
Autor:
Ryo Fukuyama, Masako Ito, Tatsuya Furuichi, Toshihiro Miyazaki, Takeshi Moriishi, Toshihisa Komori
Publikováno v:
Journal of Bone and Mineral Research. 31:1366-1380
The Bcl2 family proteins, Bcl2 and BclXL, suppress apoptosis by preventing the release of caspase activators from mitochondria through the inhibition of Bax subfamily proteins. We reported that BCL2 overexpression in osteoblasts using the 2.3 kb Col1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3973e8d81485e4916110d5ad539c7a9b
https://doi.org/10.1002/jbmr.2808
https://doi.org/10.1002/jbmr.2808