Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Ryo C. Yanagita"'
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101512- (2024)
Vitex rotundifolia is a folk medicinal plant that has been used to treat various diseases. We have previously found that the extract of its leaves shows cytotoxic and epithelial mesenchymal transition inhibitory effect in HHUA endometrial cells. In t
Externí odkaz:
https://doaj.org/article/b019b305a31645419d12b844a2520a08
Autor:
Yasuhiro Kawanami, Ryo C. Yanagita
Publikováno v:
Molecules, Vol 23, Iss 10, p 2408 (2018)
Oxazaborolidine catalyst (CBS catalyst) has been extensively used for catalytic borane reduction with a predictable absolute stereochemistry and high enantioselectivity. However, the use of isolated CBS catalyst sometimes has the drawback of low repr
Externí odkaz:
https://doaj.org/article/2d64d4a227ff4b7797652af6b2b59b8b
Autor:
Yumi Irie, Yuka Matsushima, Akiko Kita, Kunio Miki, Tatsuya Segawa, Masahiro Maeda, Ryo C. Yanagita, Kazuhiro Irie
Publikováno v:
Biochemical and Biophysical Research Communications. 621:162-167
Amyloid β-protein (Aβ) oligomers are involved in the early stages of Alzheimer's disease (AD) and antibodies against these toxic oligomers could be useful for accurate diagnosis of AD. We identified the toxic conformer of Aβ42 with a turn at posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3de0caacd94e1ce281559d90f2c787
https://doi.org/10.1016/j.bbrc.2022.07.010
https://doi.org/10.1016/j.bbrc.2022.07.010
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 86:1417-1422
HHUA endometrial adenocarcinoma cells aggregated into spheroids when cultured on collagen type I gels. 12-O-Tetradecanoylphorbol 13-acetate, a PKC activator, disassembled the spheroids through epithelial–mesenchymal transition and increased their p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77992d5316c5be77204f08664bb667d7
https://doi.org/10.1093/bbb/zbac136
https://doi.org/10.1093/bbb/zbac136
Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models
Autor:
Ayumi Uchino, Yumi Irie, Chihiro Tsukano, Taiji Kawase, Kenji Hirose, Yusuke Kageyama, Ikuo Tooyama, Ryo C. Yanagita, Kazuhiro Irie
Publikováno v:
ACS Chemical Neuroscience. 13:2517-2528
Oligomers of the amyloid β (Aβ) protein play a critical role in the pathogenesis of Alzheimer's disease. However, their heterogeneity and lability deter the identification of their tertiary structures and mechanisms of action. Aβ trimers and Aβ d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6381dd0e5a3d1a585e09cf901dfafd52
https://doi.org/10.1021/acschemneuro.2c00363
https://doi.org/10.1021/acschemneuro.2c00363
Autor:
Tomoki Sekido, Kosuke Yamamoto, Ryo C. Yanagita, Yasuhiro Kawamani, Yusuke Hanaki, Kazuhiro Irie
Publikováno v:
Bioorganicmedicinal chemistry. 73
A simplified analog (3) of aplysiatoxin was synthesized. Compound 3 has only one tetrahydropyran ring at positions 3-7, the A-ring of the spiroketal moiety, which is the conformation-controlling unit for the macrolactone ring. Nuclear magnetic resona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c78475f25043156e6ef2c3b6cc1ebb
https://pubmed.ncbi.nlm.nih.gov/36113282
https://pubmed.ncbi.nlm.nih.gov/36113282
Publikováno v:
Fundamental Toxicological Sciences. 8:69-73
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0774f226cf09420db0a7418260bb623c
https://doi.org/10.2131/fts.8.69
https://doi.org/10.2131/fts.8.69
Autor:
Jumpei Maki, Asami Oshimura, Chihiro Tsukano, Ryo C. Yanagita, Yutaka Saito, Yasubumi Sakakibara, Kazuhiro Irie
Publikováno v:
Chemical communications (Cambridge, England). 58(47)
The protein kinase C (PKC) family consists of ten isozymes and is a potential target for treating cancer, Alzheimer's disease, and HIV infection. Since known natural PKC agonists have little selectivity among the PKC isozymes, a new scaffold is neede
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b312ac6900e72ad5990a5129bbdae36b
https://pubmed.ncbi.nlm.nih.gov/35608215
https://pubmed.ncbi.nlm.nih.gov/35608215
Autor:
Yoshiyuki Suzuki, Keiichi Moritoki, Mizuki Kajiwara, Ryo C Yanagita, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie
Publikováno v:
Bioscience, biotechnology, and biochemistry. 86(8)
Simplified analogs of aplysiatoxin (ATX) such as 10-Me-aplog-1 exhibit potent antiproliferative activity toward human cancer cell lines by activating protein kinase C (PKC). However, the synthesis of 10-Me-aplog-1 involved a 23-step longest linear se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0d8ffc529f2cbe9a1f371c7e349f5a
https://pubmed.ncbi.nlm.nih.gov/35648459
https://pubmed.ncbi.nlm.nih.gov/35648459
Autor:
Yuka Matsushima, Yumi Irie, Yusuke Kageyama, Jean‐Pierre Bellier, Ikuo Tooyama, Takahito Maki, Toshiaki Kume, Ryo C. Yanagita, Kazuhiro Irie
Publikováno v:
ChemBioChem. 23
Amyloid β (Aβ) oligomers play a critical role in the pathology of Alzheimer's disease. Recently, we reported that a conformation-restricted Aβ42 with an intramolecular disulfide bond through cysteine residues at positions 17/28 formed stable oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f020b41f376f93e0fefcc9900b4f29
https://doi.org/10.1002/cbic.202200029
https://doi.org/10.1002/cbic.202200029