Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Ryo Fukuyama"'
1
Akademický článek
Effect of nattokinase on the pathological conditions in streptozotocin induced diabetic rats
Autor: Moe Yamaguchi, Ryo Fukuyama, Mitsugu Fujita
Publikováno v: Heliyon, Vol 10, Iss 7, Pp e28835- (2024)
Nattokinase (NK), also known as subtilisin NAT (EC 3.4.21.62), is a serine protease produced by Bacillus subtilis natto that has anti-inflammatory and fibrinolytic properties. To study whether NK prevents the progression of pathological changes in di
Externí odkaz: https://doaj.org/article/3ae81ef3f1db4e9b94c01f47e08a8c87
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2
Akademický článek
Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass.
Autor: Takeshi Moriishi, Ryosuke Ozasa, Takuya Ishimoto, Takayoshi Nakano, Tomoka Hasegawa, Toshihiro Miyazaki, Wenguang Liu, Ryo Fukuyama, Yuying Wang, Hisato Komori, Xin Qin, Norio Amizuka, Toshihisa Komori
Publikováno v: PLoS Genetics, Vol 16, Iss 5, p e1008586 (2020)
The strength of bone depends on bone quantity and quality. Osteocalcin (Ocn) is the most abundant noncollagenous protein in bone and is produced by osteoblasts. It has been previously claimed that Ocn inhibits bone formation and also functions as a h
Externí odkaz: https://doaj.org/article/d5d0f81ee72f41168d49071142fbdb22
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4
Runt‐related transcription factor‐2 (Runx2) is required for bone matrix protein gene expression in committed osteoblasts in mice
Autor: Hisato Komori, Qing Jiang, Ryo Fukuyama, Kosei Ito, Toshihiro Miyazaki, Toshihisa Komori, Xin Qin, Chiharu Sakane, Yuki Matsuo
Publikováno v: Journal of Bone and Mineral Research. 36:2081-2095
Runt-related transcription factor-2 (Runx2) is an essential transcription factor for osteoblast differentiation. However, its functions after the commitment into osteoblasts are controversial and remain to be clarified. We generated enhanced green fl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d65362ae8cf0ef390246aaa4da93573
https://doi.org/10.1002/jbmr.4386
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5
Akademický článek
Anti-osteoporosis Effect of 5-Bromo-2-(4-chlorobenzoyl)-(Z)-3-(2-cyano-3-hydroxybut-2-enonyl)aminobenzo[b]furan: a Novel Selective Estrogen Receptor Modulator
Autor: Ryo Fukuyama, Akio Shimokawa, Yasushi Kodama, Mitsugu Fujita, Yoshitaka Ohishi, Yuko Ando, Masao Koida, Hiromichi Nakamuta
Publikováno v: Journal of Pharmacological Sciences, Vol 116, Iss 2, Pp 214-220 (2011)
Abstract.: The benzo[b]furan derivative MU314 inhibits in vitro bone resorption as potently as β-estradiol (E2). Here, we examined the point of action on the anti-osteoporotic effects of MU314. MU314 (10 nM) suppressed lacunae formation by osteoclas
Externí odkaz: https://doaj.org/article/9a65eb77bf734b59b6c8d17972d2ac6d
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7
Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass
Autor: Takayoshi Nakano, Toshihiro Miyazaki, Norio Amizuka, Hisato Komori, Ryosuke Ozasa, Wenguang Liu, Takuya Ishimoto, Tomoka Hasegawa, Ryo Fukuyama, Yuying Wang, Xin Qin, Takeshi Moriishi, Toshihisa Komori
Publikováno v: PLoS Genetics, Vol 16, Iss 5, p e1008586 (2020)
Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass. Takeshi Moriishi et al. PLOS Genetics. 2020. 5(28)doi.org/10.1371/journal.pgen.1008586
The strength of bone d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927357de183098c187bf2faa5dc880a4
https://doaj.org/article/d5d0f81ee72f41168d49071142fbdb22
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8
Sp7 Transgenic Mice with a Markedly Impaired Lacunocanalicular Network Induced Sost and Reduced Bone Mass by Unloading
Autor: Takeshi, Moriishi, Takuro, Ito, Ryo, Fukuyama, Xin, Qin, Hisato, Komori, Hitomi, Kaneko, Yuki, Matsuo, Noriaki, Yoshida, Toshihisa, Komori
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 3173
The relationship of lacunocanalicular network structure and mechanoresponse has not been well studied. The lacunocanalicular structures differed in the compression and tension sides, in the regions, and in genders in wild-type femoral cortical bone.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3accb28a7c8077922b998779d86447
https://doi.org/10.3390/ijms23063173
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9
Akademický článek
Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading.
Autor: Takeshi Moriishi, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Takafumi Maeno, Yosuke Kawai, Hisato Komori, Toshihisa Komori
Publikováno v: PLoS ONE, Vol 7, Iss 6, p e40143 (2012)
Reduced mechanical stress is a major cause of osteoporosis in the elderly, and the osteocyte network, which comprises a communication system through processes and canaliculi throughout bone, is thought to be a mechanosensor and mechanotransduction sy
Externí odkaz: https://doaj.org/article/73231feae0de4ce2bde6f53ff982fca7
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10
Akademický článek
SP7 inhibits osteoblast differentiation at a late stage in mice.
Autor: Carolina A Yoshida, Hisato Komori, Zenjiro Maruyama, Toshihiro Miyazaki, Keishi Kawasaki, Tatsuya Furuichi, Ryo Fukuyama, Masako Mori, Kei Yamana, Kouhei Nakamura, Wenguang Liu, Satoru Toyosawa, Takeshi Moriishi, Hiroshi Kawaguchi, Kenji Takada, Toshihisa Komori
Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32364 (2012)
RUNX2 and SP7 are essential transcription factors for osteoblast differentiation at an early stage. Although RUNX2 inhibits osteoblast differentiation at a late stage, the function of SP7 at the late stage of osteoblast differentiation is not fully e
Externí odkaz: https://doaj.org/article/e639d011c37e43edae07c19f4d69c22e
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