Design of multi-epitope peptides containing HLA class-I and class-II-restricted epitopes derived from immunogenic Leishmania proteins, and evaluation of CD4+ and CD8+ T cell responses induced in cured cutaneous leishmaniasis subjects.

Autor: Sarra Hamrouni, Rachel Bras-Gonçalves, Abdelhamid Kidar, Karim Aoun, Rym Chamakh-Ayari, Elodie Petitdidier, Yasmine Messaoudi, Julie Pagniez, Jean-Loup Lemesre, Amel Meddeb-Garnaoui

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008093 (2020)

Human leishmaniasis is a public health problem worldwide for which the development of a vaccine remains a challenge. T cell-mediated immune responses are crucial for protection. Peptide vaccines based on the identification of immunodominant T cell ep

Externí odkaz: https://doaj.org/article/c109f096903c431e9559b673198335d1

In vitro evaluation of a soluble Leishmania promastigote surface antigen as a potential vaccine candidate against human leishmaniasis.

Autor: Rym Chamakh-Ayari, Rachel Bras-Gonçalves, Narges Bahi-Jaber, Elodie Petitdidier, Wafa Markikou-Ouni, Karim Aoun, Javier Moreno, Eugenia Carrillo, Poonam Salotra, Himanshu Kaushal, Narender Singh Negi, Jorge Arevalo, Francesca Falconi-Agapito, Angela Privat, Maria Cruz, Julie Pagniez, Gérard-Marie Papierok, Faten Bel Haj Rhouma, Pilar Torres, Jean-Loup Lemesre, Mehdi Chenik, Amel Meddeb-Garnaoui

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e92708 (2014)

PSA (Promastigote Surface Antigen) belongs to a family of membrane-bound and secreted proteins present in several Leishmania (L.) species. PSA is recognized by human Th1 cells and provides a high degree of protection in vaccinated mice. We evaluated

Externí odkaz: https://doaj.org/article/43367cf9df764d0c9cb36074fe25178c

In vitro evaluation of a soluble Leishmania promastigote surface antigen as a potential vaccine candidate against human leishmaniasis

Autor: Francesca Falconi-Agapito, Faten Bel Haj Rhouma, Maria Cruz, Mehdi Chenik, Himanshu Kaushal, Narender Singh Negi, Pilar Torres, Wafa Markikou-Ouni, Angela Privat, Rym Chamakh-Ayari, Amel Meddeb-Garnaoui, Eugenia Carrillo, Poonam Salotra, Julie Pagniez, Narges Bahi-Jaber, Rachel Bras-Gonçalves, Javier Moreno, Karim Aoun, Gérard-Marie Papierok, Jorge Arevalo, Jean-Loup Lemesre, Elodie Petitdidier

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e92708 (2014)
PLoS ONE
PLoS ONE, 2014, 9 (5), pp.e92708. ⟨10.1371/journal.pone.0092708⟩
PLoS ONE, Public Library of Science, 2014, 9 (5), pp.e92708. ⟨10.1371/journal.pone.0092708⟩
Repisalud
Instituto de Salud Carlos III (ISCIII)

PSA (Promastigote Surface Antigen) belongs to a family of membrane-bound and secreted proteins present in several Leishmania (L.) species. PSA is recognized by human Th1 cells and provides a high degree of protection in vaccinated mice. We evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc57344f8b58ac4c7cbd9ee15c0add7
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24786587/?tool=EBI