Výsledky vyhledávání - "Rylander, Marissa"

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Using systemic modeling and Bayesian calibration to investigate the role of the tumor microenvironment on chemoresistance

Autor: Schönfeld, Sabrina, Scarabosio, Laura, Ozkan, Alican, Rylander, Marissa Nichole, Kuttler, Christina

Using a novel modeling approach based on the so-called environmental stress level (ESL), we develop a mathematical model to describe systematically the collective influence of oxygen concentration and stiffness of the extracellular matrix on the resp

Externí odkaz: http://arxiv.org/abs/2310.19688

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Environmental stress level to model tumor cell growth and survival

Autor: Schönfeld, Sabrina, Ozkan, Alican, Scarabosio, Laura, Rylander, Marissa Nichole, Kuttler, Christina

Survival of living tumor cells underlies many influences such as nutrient saturation, oxygen level, drug concentrations or mechanical forces. Data-supported mathematical modeling can be a powerful tool to get a better understanding of cell behavior i

Externí odkaz: http://arxiv.org/abs/2201.06985

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In Vitro Vascularized Liver and Tumor Tissue Microenvironments on a Chip for Dynamic Determination of Nanoparticle Transport and Toxicity

Autor: Ozkan, Alican, Ghousifam, Neda, Hoopes, P. Jack, Rylander, Marissa Nichole

This paper presents the development of a vascularized breast tumor and healthy or tumorigenic liver microenvironments-on-a-chip connected in series. This is the first description of a vascularized multi tissue-on-a-chip microenvironment for modeling

Externí odkaz: http://arxiv.org/abs/1809.09450

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In Vitro Vascularized Tumor Platform for Modeling Tumor-Vasculature Interactions of Inflammatory Breast Cancer

Autor: Gadde, Manasa, Phillips, Caleb, Ghousifam, Neda, Sorace, Anna G., Wong, Enoch, Krishnamurthy, Savitri, Syed, Anum, Rahal, Omar, Yankeelov, Thomas E., Woodward, Wendy A., Rylander, Marissa Nichole

Inflammatory breast cancer (IBC), a rare form of breast cancer associated with increased angiogenesis and metastasis, is largely driven by tumor-stromal interactions with the vasculature and the extracellular matrix (ECM). However, there is currently

Externí odkaz: http://arxiv.org/abs/1809.06312

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Mixture theory modeling for characterizing solute transport in breast tumor tissues

Autor: Chakraborty, Sreyashi, Ozkan, Alican, Rylander, Marissa Nichole, Woodward, Wendy, Vlachos, Pavlos

Solute transport is modeled using mixture theory, applied to the nanoparticle accumulation and concentration decay in the tissue space for different vascular configurations. A comparison of a single capillary configuration (SBC) with two parallel cyl

Externí odkaz: http://arxiv.org/abs/1809.05906

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