Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.

Autor: Bashore FM; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America., Katis VL; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom., Du Y; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America., Sikdar A; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America., Wang D; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America., Bradshaw WJ; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom., Rygiel KA; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom., Leisner TM; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America., Chalk R; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom., Mishra S; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America., Williams CA; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America., Gileadi O; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom., Brennan PE; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom., Wiley JC; Sage Bionetworks, Seattle, WA, United States of America., Gockley J; Sage Bionetworks, Seattle, WA, United States of America., Cary GA; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America., Carter GW; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America., Young JE; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America., Pearce KH; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America., Fu H; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America., Axtman AD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.

Publikováno v: PloS one [PLoS One] 2024 Feb 15; Vol. 19 (2), pp. e0293548. Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024).

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.

Autor: Bashore FM; UNC Eshelman School of Pharmacy, Division of Chemical Biology and Medicinal Chemistry, Structural Genomics Consortium, University of North Carolina, Chapel Hill, NC, USA., Katis VL; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, Old Road Campus, University of Oxford, Headington, Oxford, OX3 7FZ, UK., Du Y; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, USA; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, USA., Sikdar A; UNC Eshelman School of Pharmacy, Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Chapel Hill, NC, USA., Wang D; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, USA; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, USA., Bradshaw WJ; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, Old Road Campus, University of Oxford, Headington, Oxford, OX3 7FZ, UK., Rygiel KA; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, Old Road Campus, University of Oxford, Headington, Oxford, OX3 7FZ, UK., Leisner TM; UNC Eshelman School of Pharmacy, Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Chapel Hill, NC, USA., Chalk R; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, Old Road Campus, University of Oxford, Headington, Oxford, OX3 7FZ, UK., Mishra S; University of Washington, Seattle, WA 98109., Williams AC; University of Washington, Seattle, WA 98109., Gileadi O; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, Old Road Campus, University of Oxford, Headington, Oxford, OX3 7FZ, UK.; Current address: Structural Genomics Consortium, Department of Medicine, Karolinska Hospital and Karolinska Institute, 171 76 Stockholm, Sweden., Brennan PE; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, Old Road Campus, University of Oxford, Headington, Oxford, OX3 7FZ, UK., Wiley JC; SAGE Bionetworks, Seattle, WA, USA., Gockley J; SAGE Bionetworks, Seattle, WA, USA., Cary GA; The Jackson Laboratory, Bar Harbor, ME, USA., Carter GW; The Jackson Laboratory, Bar Harbor, ME, USA., Young JE; University of Washington, Seattle, WA 98109., Pearce KH; UNC Eshelman School of Pharmacy, Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Chapel Hill, NC, USA., Fu H; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, USA; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, USA., Axtman AD; UNC Eshelman School of Pharmacy, Division of Chemical Biology and Medicinal Chemistry, Structural Genomics Consortium, University of North Carolina, Chapel Hill, NC, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 29. Date of Electronic Publication: 2023 Jul 29.

Subcellular origin of mitochondrial DNA deletions in human skeletal muscle.

Autor: Vincent AE; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom., Rosa HS; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom., Pabis K; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom., Lawless C; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom., Chen C; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom., Grünewald A; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.; Molecular and Functional Neurobiology Group, Luxembourg Center for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Rygiel KA; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom., Rocha MC; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom., Reeve AK; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom., Falkous G; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom., Perissi V; Department of Biochemistry, Boston University School of Medicine, Boston, MA., White K; Electron Microscopy Research Services, Newcastle University, Newcastle upon Tyne, United Kingdom., Davey T; Electron Microscopy Research Services, Newcastle University, Newcastle upon Tyne, United Kingdom., Petrof BJ; Meakins-Christie Laboratories, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada., Sayer AA; National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom., Cooper C; Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom., Deehan D; Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom., Taylor RW; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom., Turnbull DM; Wellcome Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom., Picard M; Department of Psychiatry, Division of Behavioral Medicine, Columbia University Medical Center, New York, NY.; Department of Neurology and Columbia Translational Neuroscience Initiative, H. Houston Merritt Center, Columbia University Medical Center, New York, NY.; Columbia University Aging Center, Columbia University, New York, NY.

Publikováno v: Annals of neurology [Ann Neurol] 2018 Aug; Vol. 84 (2), pp. 289-301. Date of Electronic Publication: 2018 Aug 21.

Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo.

Autor: Russell OM; Wellcome Centre for Mitochondrial Research, Institutes of Neuroscience and Cellular and Molecular Bioscience, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, Tyne and Wear, UK., Fruh I; Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland., Rai PK; Wellcome Centre for Mitochondrial Research, Institutes of Neuroscience and Cellular and Molecular Bioscience, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, Tyne and Wear, UK., Marcellin D; Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland., Doll T; Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland., Reeve A; Wellcome Centre for Mitochondrial Research, Institutes of Neuroscience and Cellular and Molecular Bioscience, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, Tyne and Wear, UK., Germain M; Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland., Bastien J; Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland., Rygiel KA; Wellcome Centre for Mitochondrial Research, Institutes of Neuroscience and Cellular and Molecular Bioscience, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, Tyne and Wear, UK., Cerino R; Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland., Sailer AW; Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland., Lako M; Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom., Taylor RW; Wellcome Centre for Mitochondrial Research, Institutes of Neuroscience and Cellular and Molecular Bioscience, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, Tyne and Wear, UK., Mueller M; Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland., Lightowlers RN; Wellcome Centre for Mitochondrial Research, Institutes of Neuroscience and Cellular and Molecular Bioscience, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, Tyne and Wear, UK., Turnbull DM; Wellcome Centre for Mitochondrial Research, Institutes of Neuroscience and Cellular and Molecular Bioscience, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, Tyne and Wear, UK. doug.turnbull@newcastle.ac.uk., Helliwell SB; Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland. stephen.helliwell@novartis.com.

Publikováno v: Scientific reports [Sci Rep] 2018 Jan 29; Vol. 8 (1), pp. 1799. Date of Electronic Publication: 2018 Jan 29.

Care of cancer patients with liver and bone metastases - the place of pharmaceutical care in a balanced plan, focused on the patient's needs and goals.

Autor: Rygiel KA; Department of Family Practice, Medical University of Silesia, Zabrze, Poland., Drozd M; Chair and Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland., Bułaś L; Department of Pharmaceutica, Medical University of Silesia, Katowice, Poland.

Publikováno v: Archives of medical science : AMS [Arch Med Sci] 2017 Oct; Vol. 13 (6), pp. 1483-1492. Date of Electronic Publication: 2016 Jun 13.