A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase.

Autor: Ragavan VN; Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany.; Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Bedford Park, Adelaide, SA, Australia., Nair PC; Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Bedford Park, Adelaide, SA, Australia.; Flinders Health and Medical Research Institute (FHMRI), College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Cancer Program, South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide, Adelaide, SA, Australia.; Discipline of Medicine, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia., Jarzebska N; Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany., Angom RS; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL, USA., Ruta L; Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, Perugia, Italy., Bianconi E; Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, Perugia, Italy., Grottelli S; Department of Medicine and Surgery, University of Perugia, P.le L. Sevari 1, Perugia, Italy., Tararova ND; DAPCEL, Inc., Cleveland, OH, USA., Ryazanskiy D; DAPCEL, Inc., Cleveland, OH, USA., Lentz SR; Department of Internal Medicine, The University of Iowa Carver College of Medicine, Iowa City, IA, USA., Tommasi S; Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Bedford Park, Adelaide, SA, Australia., Martens-Lobenhoffer J; Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany., Suzuki-Yamamoto T; Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan., Kimoto M; Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan., Rubets E; Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany., Chau S; Department of Cardiovascular Medicine, Mayo Clinic College of Medicine and Science, Rochester, NY, USA., Chen Y; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Hu X; Institute of Molecular Medicine, Beijing University, Beijing, China., Bernhardt N; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Spieth PM; Department of Anesthesiology and Critical Care Medicine, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany., Weiss N; Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany., Bornstein SR; Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany.; School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Mukhopadhyay D; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL, USA., Bode-Böger SM; Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany., Maas R; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU New - Research Center for New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Wang Y; Department of Cardiovascular Medicine, Mayo Clinic College of Medicine and Science, Rochester, NY, USA., Macchiarulo A; Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, Perugia, Italy., Mangoni AA; Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Bedford Park, Adelaide, SA, Australia., Cellini B; Department of Medicine and Surgery, University of Perugia, P.le L. Sevari 1, Perugia, Italy., Rodionov RN; Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany. Roman.Rodionov@uniklinikum-dresden.de.; College of Medicine and Public Health, Flinders University and Flinders Medical Center, Adelaide, SA, Australia. Roman.Rodionov@uniklinikum-dresden.de.

Publikováno v: Nature communications [Nat Commun] 2023 Jun 09; Vol. 14 (1), pp. 3392. Date of Electronic Publication: 2023 Jun 09.

Arginine, Transsulfuration, and Folic Acid Pathway Metabolomics in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.

Autor: Zinellu, Angelo¹ (AUTHOR) azinellu@uniss.it, Mangoni, Arduino A.^2,3 (AUTHOR) arduino.mangoni@flinders.edu.au

Publikováno v: Cells (2073-4409). Sep2023, Vol. 12 Issue 17, p2180. 25p.

Asymmetric Dimethylarginine Enables Depolarizing Spikes and Vasospasm in Mesenteric and Coronary Resistance Arteries.

Autor: Ng, Yu Y. Hanson, Dora, Kim A., Lemmey, Hamish A.L., Lin, JinHeng, Alden, James, Wallis, Lillian, Donovan, Lucy, Shorthose, Oliver, Leiper, Fiona C., Leiper, James, Garland, Christopher J.

Publikováno v: Hypertension (0194911X); Apr2024, Vol. 81 Issue 4, p764-775, 12p