The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings

Autor: Ryann E. Shor, Jinxiang Dai, Sun‐Young Lee, Laura Pisarsky, Irina Matei, Serena Lucotti, David Lyden, Mina J. Bissell, Cyrus M. Ghajar

Publikováno v: Molecular Oncology, Vol 16, Iss 1, Pp 130-147 (2022)

Dormant, disseminated tumor cells (DTCs) are thought to be the source of breast cancer metastases several years or even decades after initial treatment. To date, a selective therapy that leads to their elimination has not been discovered. While dorma

Externí odkaz: https://doaj.org/article/a3a3a49dc68740cfb9870a78fd1324e9

The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings

Autor: David Lyden, Laura Pisarsky, Cyrus M. Ghajar, Irina Matei, Sun-Young Lee, Serena Lucotti, Mina J. Bissell, Jinxiang Dai, Ryann E Shor

Publikováno v: Molecular Oncology
Molecular Oncology, Vol 16, Iss 1, Pp 130-147 (2022)

Dormant, disseminated tumor cells (DTCs) are thought to be the source of breast cancer metastases several years or even decades after initial treatment. To date, a selective therapy that leads to their elimination has not been discovered. While dorma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6e9d695bd3f27a618d4ca4d8d16ada
https://doi.org/10.1002/1878-0261.13031

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

Autor: Andrea R. Lim, Patrick Carlson, Emma M Schweitzer, Arko Dasgupta, Kirk C. Hansen, Cyrus M. Ghajar, Erica T. Goddard, David A. Cheresh, Sarah B Crist, Alexander S. Barrett, Ryann E Shor, Peter S. Nelson, Ilsa Coleman, Jeanna Kim, Jinxiang Dai, Candice Alexandra Grzelak

Publikováno v: Nature cell biology, vol 21, iss 2
Carlson, Patrick; Dasgupta, Arko; Grzelak, Candice A; Kim, Jeanna; Barrett, Alexander; Coleman, Ilsa M; et al.(2019). Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.. Nature cell biology, 21(2), 238-250. doi: 10.1038/s41556-018-0267-0. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/2bq96054

The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast cancer with localized disease. DTCs persist in distant tissues despite systemic administration of adjuvant chemothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a698c963e7aa07151dab145a070d532
https://europepmc.org/articles/PMC6948102/