Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen Candida albicans

Autor: Leenah Alaalm, Julia L. Crunden, Mark Butcher, Ulrike Obst, Ryann Whealy, Carolyn E. Williamson, Heath E. O’Brien, Christiane Schaffitzel, Gordon Ramage, James Spencer, Stephanie Diezmann

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

The highly conserved, ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. In human pathogenic fungi, which kill more than 1.6 million patients each year worldwide, Hsp90 governs cellula

Externí odkaz: https://doaj.org/article/ca17f57cc0c64ecf8c292a3a3f97e118

Identification and phenotypic characterization of Hsp90 phosphorylation sites that modulate virulence traits in the major human fungal pathogen Candida albicans

Autor: Ryann Whealy, Julia L. Crunden, Christiane Schaffitzel, Carolyn E. Williamson, Ulrike Obst, Leenah Alaalm, Mark C. Butcher, Heath E. O’Brien, James Spencer, Stephanie Diezmann, Gordon Ramage

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Alaalm, L, Crunden, J L, Butcher, M, Obst, U, Whealy, R, Williamson, C, O'Brien, H, Berger-Schaffitzel, C H, Ramage, G, Spencer, J & Diezmann, S 2021, ' Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen Candida albicans ', Frontiers in Cellular and Infection Microbiology, vol. 11, 637836 . https://doi.org/10.3389/fcimb.2021.637836

The highly conserved, ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. In human pathogenic fungi, which kill more than 1.6 million patients each year worldwide, Hsp90 governs cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda6025d9c09fdff3737256c6e8c53f0
https://eprints.gla.ac.uk/242766/1/242766.pdf

A novel Hsp90 phospho-switch modulates virulence in the major human fungal pathogenCandida albicans

Autor: Mark C. Butcher, Ryann Whealy, Stephanie Diezmann, Carolyn E. Williamson, Ulrike Obst, Leenah Alaalm, Gordon Ramage, Heath E. O’Brien, Julia L. Crunden, Christiane Schaffitzel

The ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. Hsp90 also regulates cellular morphogenesis, drug resistance, and virulence in human pathogenic fungi, which kill more than 1.6 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76a1990477d37538cbb425d3fd1706fb
https://doi.org/10.1101/2020.09.23.309831

Characterization of Neonatal Abstinence Syndrome in Arizona from 2010-2017

Autor: Jill Hager Cocking, Jarrett J. Barber, Joseph Spadafino, Emery R. Eaves, Sara A. Clancey, Rita Wright, Ryann Whealy, Crystal M. Hepp

This study aimed to characterize the population of newborn infants with neonatal abstinence syndrome (NAS) and mothers who were opioid dependent at the time of giving birth, in Arizona. We analyzed approximately 1.2 million electronic medical records

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8417f7872e2b996fd4e5ec9bf9d4205f

Causative agents of early childhood caries: challenges and solutions in culturing and sequencing

Autor: Daryn Erickson, Viacheslav Y. Fofanov, Crystal M. Hepp, Ryann Whealy, Jill Hager Cocking

Publikováno v: Access Microbiology. 1

Dental caries, also known as cavities or dental decay, effects children at a rate five times higher than asthma in the United States. This disease is highly preventable but causes extreme pain and costs millions of dollars to treat every year. The pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5b342c3e2752c88deca4ba06d19be08
https://doi.org/10.1099/acmi.ac2019.po0124