Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Ryan Zurakowski"'
Autor:
Marilia R. Pinzone, Sam Weissman, Alexander O. Pasternak, Ryan Zurakowski, Stephen Migueles, Una O’Doherty
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Historically, naive cells have been considered inconsequential to HIV persistence. Here, we compared the contributions of naive and memory cells to the reservoirs of individuals with a spectrum of reservoir sizes and variable immunological control. W
Externí odkaz:
https://doaj.org/article/07e18e798f2e4473be66cf7c80da6216
Autor:
Emmanuele Venanzi Rullo, Marilia Rita Pinzone, LaMont Cannon, Sam Weissman, Manuela Ceccarelli, Ryan Zurakowski, Giuseppe Nunnari, Una O’Doherty
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Despite the efficacy of antiretroviral therapy (ART), HIV persists in a latent form and remains a hurdle to eradication. CD4+ T lymphocytes harbor the majority of the HIV reservoir, but the role of individual subsets remains unclear. CD4+ T cells wer
Externí odkaz:
https://doaj.org/article/3420deeaca514f978eefbad384131d6d
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Although combined anti-retroviral therapy (cART) suppresses plasma HIV viremia below the limit of detection in a majority of HIV patients, evidence is emerging that the distribution of the anti-retroviral drugs is heterogeneous in tissue. Clinical st
Externí odkaz:
https://doaj.org/article/3479a2ef5b0c4df3a00a75eadd6e72df
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-11 (2018)
Abstract Reverse transcription of HIV-1 results in the generation of a linear cDNA that serves as the precursor to the integrated provirus. Other classes of extrachromosomal viral cDNA molecules can be found in acutely infected cells including the 1-
Externí odkaz:
https://doaj.org/article/95e2bf2039da4691b86de163df8411b4
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206700 (2018)
Clinical trials are necessary in order to develop treatments for diseases; however, they can often be costly, time consuming, and demanding to the patients. This paper summarizes several common methods used for optimal design that can be used to addr
Externí odkaz:
https://doaj.org/article/a6e1e383fb5643e882b812bc2c2455d6
Autor:
Ryan Zurakowski
Publikováno v:
EBioMedicine, Vol 2, Iss 12, Pp 1867-1868 (2015)
Externí odkaz:
https://doaj.org/article/1227662716da45aa88473dc176af180d
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40198 (2012)
Mathematical models based on ordinary differential equations (ODE) have had significant impact on understanding HIV disease dynamics and optimizing patient treatment. A model that characterizes the essential disease dynamics can be used for predictio
Externí odkaz:
https://doaj.org/article/42343ccce78f48ddb47f52ded5b531fb
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27047 (2011)
The development of resistant strains of HIV is the most significant barrier to effective long-term treatment of HIV infection. The most common causes of resistance development are patient noncompliance and pre-existence of resistant strains. In this
Externí odkaz:
https://doaj.org/article/048867bd6f3e407b985d174c8cd76465
To govern organ size, shape, and function, cell-secreted diffusible molecules called morphogens spatially pattern cell differentiation, gene expression, and proliferation. Local morphogen concentration governs cell differentiation through gene regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b84b03773ac2677de3c22f84e238ec6
https://doi.org/10.1101/2023.02.26.530111
https://doi.org/10.1101/2023.02.26.530111
Publikováno v:
bioRxiv
Lymph nodes (LNs) serve as a sanctuary site for HIV viruses due to the heterogeneous distribution of the antiretrovirals (ARVs) inside the LNs. There is an ongoing debate whether this represents ongoing cycles of viral replication in the LNs or merel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1f558e033d266c53ddf69202c98e0a
https://doi.org/10.1101/2023.02.18.529086
https://doi.org/10.1101/2023.02.18.529086