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GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle.

Autor: Marcotte GR; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; University of Iowa, Iowa City, Iowa, USA., Miller MJ; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; University of Iowa, Iowa City, Iowa, USA., Kunz HE; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Ryan ZC; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Strub MD; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Vanderboom PM; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Heppelmann CJ; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Chau S; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Von Ruff ZD; University of Texas Medical Branch, Galveston, Texas, USA., Kilroe SP; University of Texas Medical Branch, Galveston, Texas, USA., McKeen AT; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; University of Iowa, Iowa City, Iowa, USA., Dierdorff JM; University of Iowa, Iowa City, Iowa, USA., Stern JI; Department of Neurology and., Nath KA; Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Grueter CE; University of Iowa, Iowa City, Iowa, USA., Lira VA; University of Iowa, Iowa City, Iowa, USA., Judge AR; University of Florida, Gainesville, Florida, USA.; Emmyon, Inc., Rochester, Minnesota, USA., Rasmussen BB; University of Texas Medical Branch, Galveston, Texas, USA.; Emmyon, Inc., Rochester, Minnesota, USA.; University of Texas Health Science Center, San Antonio, Texas, USA., Nair KS; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Lanza IR; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Ebert SM; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Emmyon, Inc., Rochester, Minnesota, USA., Adams CM; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Emmyon, Inc., Rochester, Minnesota, USA.

Publikováno v: JCI insight [JCI Insight] 2023 Nov 22; Vol. 8 (22). Date of Electronic Publication: 2023 Nov 22.

Multi-Omic Architecture of Obstructive Hypertrophic Cardiomyopathy.

Autor: Garmany R; Mayo Clinic Medical Scientist Training Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic Alix School of Medicine, Rochester, MN (R.G.).; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Rochester, MN (R.G., J.M.B., D.J.T., M.J.A.)., Bos JM; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Rochester, MN (R.G., J.M.B., D.J.T., M.J.A.).; Department of Cardiovascular Medicine (J.M.B., J.R.G., J.J.M., S.R.O., M.J.A.), Windland Smith Rice Genetic Heart Rhythm Clinic, Rochester, MN.; Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology (J.M.B., M.J.A.), Windland Smith Rice Genetic Heart Rhythm Clinic, Rochester, MN., Tester DJ; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Rochester, MN (R.G., J.M.B., D.J.T., M.J.A.)., Giudicessi JR; Department of Cardiovascular Medicine (J.M.B., J.R.G., J.J.M., S.R.O., M.J.A.), Windland Smith Rice Genetic Heart Rhythm Clinic, Rochester, MN., Dos Remedios CG; Mechanobiology Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, Australia (C.G.dR.)., Dasari S; Department of Quantitative Health Sciences, Division of Computational Biology (S.D., N.K.N., A.A.N.), Mayo Clinic, Rochester, MN., Nagaraj NK; Department of Quantitative Health Sciences, Division of Computational Biology (S.D., N.K.N., A.A.N.), Mayo Clinic, Rochester, MN., Nair AA; Department of Quantitative Health Sciences, Division of Computational Biology (S.D., N.K.N., A.A.N.), Mayo Clinic, Rochester, MN., Johnson KL; Proteomics Core (K.L.J., Z.C.R.), Mayo Clinic, Rochester, MN., Ryan ZC; Proteomics Core (K.L.J., Z.C.R.), Mayo Clinic, Rochester, MN., Maleszewski JJ; Department of Cardiovascular Medicine (J.M.B., J.R.G., J.J.M., S.R.O., M.J.A.), Windland Smith Rice Genetic Heart Rhythm Clinic, Rochester, MN.; Department of Laboratory Medicine and Pathology (J.J.M.), Mayo Clinic, Rochester, MN., Ommen SR; Department of Cardiovascular Medicine (J.M.B., J.R.G., J.J.M., S.R.O., M.J.A.), Windland Smith Rice Genetic Heart Rhythm Clinic, Rochester, MN., Dearani JA; Department of Cardiovascular Surgery (J.A.D), Mayo Clinic, Rochester, MN., Ackerman MJ; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Rochester, MN (R.G., J.M.B., D.J.T., M.J.A.).; Department of Cardiovascular Medicine (J.M.B., J.R.G., J.J.M., S.R.O., M.J.A.), Windland Smith Rice Genetic Heart Rhythm Clinic, Rochester, MN.; Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology (J.M.B., M.J.A.), Windland Smith Rice Genetic Heart Rhythm Clinic, Rochester, MN.

Publikováno v: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2023 Apr; Vol. 16 (2), pp. e003756. Date of Electronic Publication: 2023 Feb 20.

The secretome of senescent preadipocytes influences the phenotype and function of cells of the vascular wall.

Autor: Parvizi M; Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA., Ryan ZC; Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA., Ebtehaj S; Department of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA., Arendt BK; Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA., Lanza IR; Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA. Electronic address: lanza.ian@mayo.edu.

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2021 Jan 01; Vol. 1867 (1), pp. 165983. Date of Electronic Publication: 2020 Sep 28.