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Akademický článek

4-Phenyl-thiazole-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase do not alleviate orofacial inflammatory pain in female rats

Autor: Daniel Carr, Christopher Chin, Tiffany Chacon, Monijeh Khoja Herawi, Michael Gonzalez, Ryan West, Christophe Morisseau, Bruce D. Hammock, Stevan Pecic, Ram Kandasamy

Publikováno v: BBA Advances, Vol 6, Iss , Pp 100119- (2024)

Pain arising from trigeminal systems such as headache is common, debilitating, and current treatments (e.g., sumatriptan) are limited. New treatments that target novel mechanisms of action may be required to innovate both short- and long-term pain th

Externí odkaz: https://doaj.org/article/40c250400278494e80f2caeb253914f4

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Akademický článek

Identification and Monitoring of Nucleotide Repeat Expansions Using Southern Blotting in Drosophila Models of C9orf72 Motor Neuron Disease and Frontotemporal Dementia

Autor: Joanne Sharpe, Nikki Harper, Ryan West

Publikováno v: Bio-Protocol, Vol 12, Iss 10 (2022)

Repeat expansion diseases, including fragile X syndrome, Huntington’s disease, and C9orf72-related motor neuron disease and frontotemporal dementia, are a group of disorders associated with polymorphic expansions of tandem repeat nucleotide sequenc

Externí odkaz: https://doaj.org/article/f4b3aea7b83b44188adc4d6405fc0248

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Multi-Target Directed Ligands for the Treatment of Alzheimer’s Disease

Autor: Ryan West, Stevan Pecic

Publikováno v: ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21d35e2ee97f6c9be26d3c27d9518f33
https://doi.org/10.1124/jpet.122.183150

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Evaluation of a pharmacy technician-based medication prior authorization program

Autor: Ryan West, Jessica Brown, Will Finley, Alex S. Hill, Jeff Fenerty, Sarah Dunaway, Tiffany Miller, Jesse Bates, Ron Carico, Dustin Baum

Publikováno v: Journal of the American Pharmacists Association. 61:425-431

Background The roles of pharmacy technicians in clinical practice are being explored. Medication prior authorizations (PAs) from insurers can lead to delays in pharmacotherapy. Objective To assess the efficiency of our clinical pharmacy technicians i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a744e58256e716352eaa82d267e93e8
https://doi.org/10.1016/j.japh.2021.02.016

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Automated Generation of Novel Fragments Using Screening Data, a Dual SMILES Autoencoder, Transfer Learning and Syntax Correction

Autor: Justin Bower, Ryan West, Angelo Pugliese, Kirsten McAulay, Alan Bilsland

Publikováno v: Journal of Chemical Information and Modeling. 61:2547-2559

Fragment-based hit identification (FBHI) allows proportionately greater coverage of chemical space using fewer molecules than traditional high-throughput screening approaches. However, effectively exploiting this advantage is highly dependent on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3657a31f2c9177a95282ff3d8dfa8db4
https://doi.org/10.1021/acs.jcim.0c01226

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