Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage

Autor: Maria Ercu, Michael B. Mücke, Tamara Pallien, Lajos Markó, Anastasiia Sholokh, Carolin Schächterle, Atakan Aydin, Alexa Kidd, Stephan Walter, Yasmin Esmati, Brandon J. McMurray, Daniella F. Lato, Daniele Yumi Sunaga-Franze, Philip H. Dierks, Barbara Isabel Montesinos Flores, Ryan Walker-Gray, Maolian Gong, Claudia Merticariu, Kerstin Zühlke, Michael Russwurm, Tiannan Liu, Theda U.P. Batolomaeus, Sabine Pautz, Stefanie Schelenz, Martin Taube, Hanna Napieczynska, Arnd Heuser, Jenny Eichhorst, Martin Lehmann, Duncan C. Miller, Sebastian Diecke, Fatimunnisa Qadri, Elena Popova, Reika Langanki, Matthew A. Movsesian, Friedrich W. Herberg, Sofia K. Forslund, Dominik N. Müller, Tatiana Borodina, Philipp G. Maass, Sylvia Bähring, Norbert Hübner, Michael Bader, Enno Klussmann

Publikováno v: Circulation. 146(23)

Background: Phosphodiesterase 3A ( PDE3A ) gain-of-function mutations cause hypertension with brachydactyly (HTNB) and lead to stroke. Increased peripheral vascular resistance, rather than salt retention, is responsible. It is surprising that the few

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a089736582e609c01bb8cc18aa72821
https://pubmed.ncbi.nlm.nih.gov/36259389

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

Autor: Sandrine Baltzer, Timur Bulatov, Christopher Schmied, Andreas Krämer, Benedict-Tilman Berger, Andreas Oder, Ryan Walker-Gray, Christin Kuschke, Kerstin Zühlke, Jenny Eichhorst, Martin Lehmann, Stefan Knapp, John Weston, Jens Peter von Kries, Roderich D. Süssmuth, Enno Klussmann

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 763, p 763 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 763
Int J Mol Sci

The cAMP-dependent aquaporin-2 (AQP2) redistribution from intracellular vesicles into the plasma membrane of renal collecting duct principal cells induces water reabsorption and fine-tunes body water homeostasis. However, the mechanisms controlling t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002b63594f5f82374993644552d9facf

Abstract 12201: Dissecting the Protective Effect of Phosphodiesterase 3A Hyperactivity on the Heart Using Single Nuclei Sequencing and Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Autor: Michael B Mücke, Tamara Pallien, Philip Dierks, Ryan Walker-Gray, Anastasiia Sholokh, Duncan C Miller, Sebastian Diecke, Norbert Hubner, Enno Klussmann

Publikováno v: Circulation. 144

Mutations causing hyperactivity of phosphodiesterase 3A (PDE3A) lead to autosomal dominant hypertension with brachydactyly type E. Affected patients suffer from profoundly increased blood pressure and, if untreated, die from stroke at the age of 50 y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95a25cdf12b10b5b2304f163d7c7686d
https://doi.org/10.1161/circ.144.suppl_1.12201

The role of AKAP12 in coordination of VEGF‐induced endothelial cell motility

Autor: Ryan Walker-Gray, Enno Klussmann

Publikováno v: Acta Physiologica. 228

In this issue of Acta Physiologica, Benz et al. study the role of one important protein in the cyclic AMP signaling pathway, the A-kinase anchoring (AKAP)12. The downstream effects stemming from cAMP release are tightly controlled and activate a prof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db4d73972759422f2723c442d5d1fab5
https://doi.org/10.1111/apha.13359

Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches

Autor: Florian Stengel, Ryan Walker-Gray, Matthew G. Gold

Protein phosphorylation by cyclic AMP-dependent protein kinase (PKA) underlies key cellular processes, including sympathetic stimulation of heart cells, and potentiation of synaptic strength in neurons. Unrestrained PKA activity is pathological, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3f009815ed5d5dcaf2aa93299e6185
https://europepmc.org/articles/PMC5625894/