Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ryan W.J. Steel"'
Autor:
Ryan W.J. Steel, Shuxiong Chen, Lucas Huntimer, Benjamin Evert, Robyn McConville, Julie Healer, Justin A Boddey, Bernd H. A. Rehm
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-12 (2021)
NPJ Vaccines
NPJ Vaccines
The current Malaria RTS,S vaccine is based on virus-like particles (VLPs) comprising the NANP repetitive epitopes from the cicumsporozoite protein (CSP) of Plasmodium falciparum. This vaccine has limited efficacy, only preventing severe disease in ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3ff80ed1a75e01867bbc691fd24ed5
https://doaj.org/article/20819287a4164343b238a1a5bdf5f86f
https://doaj.org/article/20819287a4164343b238a1a5bdf5f86f
Autor:
Melisa Gualdrón-López, Miriam Díaz-Varela, Gigliola Zanghi, Iris Aparici-Herraiz, Ryan W.J. Steel, Carola Schäfer, Pol Cuscó, Vorada Chuenchob, Niwat Kangwangransan, Zachary P. Billman, Tayla M. Olsen, Juan R. González, Wanlapa Roobsoong, Jetsumon Sattabongkot, Sean C. Murphy, Sebastian A. Mikolajczak, Eva Borràs, Eduard Sabidó, Carmen Fernandez-Becerra, Erika L. Flannery, Stefan H.I. Kappe, Hernando A. del Portillo
Publikováno v:
Molecular & Cellular Proteomics. 21:100406
Latent liver stages termed hypnozoites cause relapsing Plasmodium vivax malaria infection and represent a major obstacle in the goal of malaria elimination. Hypnozoites are clinically undetectable, and presently, there are no biomarkers of this persi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b45c9c9d46c0502bbdf6f74b7dfa99e
https://doi.org/10.1016/j.mcpro.2022.100406
https://doi.org/10.1016/j.mcpro.2022.100406
Autor:
Helen Thomas, Will Betz, Robert L. Moritz, Bridget S. Fisher, Jim Freeth, Sara Carbonetti, Debashree Goswami, Jo Soden, Vladimir Vigdorovich, Thao Nguyen, Kristian E. Swearingen, Nicholas Dambrauskas, Brandon K. Wilder, Ryan W.J. Steel, Sudhir Kumar, Nelly Camargo, D. Noah Sather, Silvia A. Arredondo, Stefan H. I. Kappe
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Following their inoculation by the bite of an infected Anopheles mosquito, the malaria parasite sporozoite forms travel from the bite site in the skin into the bloodstream, which transports them to the liver. The thrombospondin-related anonymous prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fac39457570a01ea2751bb26beac1f
https://doi.org/10.1038/s41598-021-90722-5
https://doi.org/10.1038/s41598-021-90722-5
Autor:
Hayley E. Bullen, Helene Jousset Sabroux, Sandra Duffy, Justin A Boddey, Ryan W.J. Steel, Maria R. Gancheva, Kym N Lowes, Paul R. Gilson, Alan F. Cowman, Vicky M. Avery, Trent D. Ashton, Brad E. Sleebs, Anna Ngo, Danny W. Wilson, Molly Parkyn Schneider, Paola Favuzza, Ornella Romeo, Nghi Nguyen
Publikováno v:
Bioorganic Chemistry. 117:105359
Malaria is a devastating disease caused by Plasmodium parasites. Emerging resistance against current antimalarial therapeutics has engendered the need to develop antimalarials with novel structural classes. We recently described the identification an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d3a32c77c1259d7e0b0fbf0da3382e
https://doi.org/10.1016/j.bioorg.2021.105359
https://doi.org/10.1016/j.bioorg.2021.105359
Publikováno v:
Future Microbiology. 11:1563-1579
Malaria remains a significant public health burden with 214 million new infections and over 400,000 deaths in 2015. Elucidating relevant Plasmodium parasite biology can lead to the identification of novel ways to control and ultimately eliminate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4cf0752db64368bca7a0fca83abc58
https://doi.org/10.2217/fmb-2016-0077
https://doi.org/10.2217/fmb-2016-0077
Autor:
Janni Christensen, David B. Olsen, Kitsanapong Reaksudsan, Jennifer K. Thompson, Kai-Yuan Guo, Wai-Hong Tham, Tony Triglia, Christopher W. Boyce, Justin A Boddey, Lianyun Zhao, Nicholas Murgolo, Marissa Vavrek, Tanweer A. Khan, Alan F. Cowman, Helene Jousset Sabroux, Jocelyn Sietsma Penington, Ryan W.J. Steel, Manuel de Lera Ruiz, Brad E. Sleebs, Jonathan A. Robbins, Zhuyan Guo, Matthias Rottmann, Paola Favuzza, Anna Ngo, Lachlan Richardson, Julie Healer, John A. Mccauley, Kate E. Jarman, Sash Lopaticki, Tony Papenfuss, Melanie H. Dietrich, Mengwei Hu
Publikováno v:
Cell Host & Microbe
Summary Artemisin combination therapy (ACT) is the main treatment option for malaria, which is caused by the intracellular parasite Plasmodium. However, increased resistance to ACT highlights the importance of finding new drugs. Recently, the asparti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4561fd327b3a0109fe00b5a063d39738
https://pubmed.ncbi.nlm.nih.gov/32272073
https://pubmed.ncbi.nlm.nih.gov/32272073
Autor:
Justin A Boddey, Marc Pellegrini, Annie S. P. Yang, Pravin Rajasekaran, Sash Lopaticki, Lisa J Ioannidis, Liana Mackiewicz, Gregor Ebert, Cody C. Allison, Ryan W.J. Steel, Matthew T. O'Neill, Marcel Doerflinger, Philip Arandjelovic, Sara M. Erickson, John Silke
Publikováno v:
Cell Reports. 30:4343-4354.e4
Plasmodium sporozoites infect the liver and develop into exoerythrocytic merozoites that initiate blood-stage disease. The hepatocyte molecular pathways that permit or abrogate parasite replication and merozoite formation have not been thoroughly exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda5331a5a6030a7262a643bc73143e4
https://doi.org/10.1016/j.celrep.2020.03.032
https://doi.org/10.1016/j.celrep.2020.03.032
Autor:
Stefan H. I. Kappe, Dorender A Dankwa, Thomas Martinson, Niwat Kangwanrangsan, Anke Harupa, Ashley M. Vaughan, Nelly Camargo, Kristian E. Swearingen, William Betz, Motomi Torii, Tomoko Ishino, Vladimir Vigdorovich, Robert L. Moritz, Ryan W.J. Steel, Silvia A. Arredondo, Noah Sather, Sebastian A. Mikolajczak, Brian G. Oliver
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Within the liver, Plasmodium sporozoites traverse cells searching for a "suitable" hepatocyte, invading these cells through a process that results in the formation of a parasitophorous vacuole (PV), within which the parasite undergoes intracellular r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6da9ee3aaaf65feacc332663da0597
https://www.frontiersin.org/article/10.3389/fcimb.2018.00413/full
https://www.frontiersin.org/article/10.3389/fcimb.2018.00413/full
Autor:
Ryan W.J. Steel, Vorada Chuenchob, Jetsumon Sattabongkot, Steven P. Maher, Brian G. Oliver, Sara Carbonetti, Dennis E. Kyle, Carola Schäfer, Stefan H. I. Kappe, Vladimir Vigdorovich, Erika L. Flannery, Sebastian A. Mikolajczak, D. Noah Sather, Nicholas Dambrauskas, Wanlapa Roobsoong
Publikováno v:
Malaria Journal
Malaria Journal, Vol 17, Iss 1, Pp 1-10 (2018)
Malaria Journal, Vol 17, Iss 1, Pp 1-10 (2018)
Background Plasmodium vivax is the most geographically widespread of the human malaria parasites, causing 50,000 to 100,000 deaths annually. Plasmodium vivax parasites have the unique feature of forming dormant liver stages (hypnozoites) that can rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e021a05e7e3d488740d3fabb4df5d139
https://pubmed.ncbi.nlm.nih.gov/30333026
https://pubmed.ncbi.nlm.nih.gov/30333026
Autor:
Will Betz, Thao Nguyen, Stefan H. I. Kappe, Nelly Carmago, Isabelle Zenklusen, Hayley Cardamone, Brandon K. Sack, Claudia Daubenberger, Salim Abdulla, Sebastian A. Mikolajczak, Kamaka Ramadhani, Stephen L. Hoffman, Said Jongo, B. Kim Lee Sim, Ryan W.J. Steel, Matthew Fishbaugher, Erika L. Flannery
Publikováno v:
The Journal of infectious diseases. 217(10)
Background The assessment of antibody responses after immunization with radiation-attenuated, aseptic, purified, cryopreserved Plasmodium falciparum sporozoites (Sanaria PfSPZ Vaccine) has focused on IgG isotype antibodies. Here, we aimed to investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdece9b50caaf82f30ddb5b22cb1afa4
https://pubmed.ncbi.nlm.nih.gov/29438525
https://pubmed.ncbi.nlm.nih.gov/29438525