Stability of the cytosine methylome during post-testicular sperm maturation in mouse.

Autor: Carolina Galan, Ryan W Serra, Fengyun Sun, Vera D Rinaldi, Colin C Conine, Oliver J Rando

Publikováno v: PLoS Genetics, Vol 17, Iss 3, p e1009416 (2021)

Beyond the haploid genome, mammalian sperm carry a payload of epigenetic information with the potential to modulate offspring phenotypes. Recent studies show that the small RNA repertoire of sperm is remodeled during post-testicular maturation in the

Externí odkaz: https://doaj.org/article/14b27601fe0b45368ddc484dd0ae983e

Stability of the cytosine methylome during post-testicular sperm maturation in mouse

Autor: Vera D. Rinaldi, Colin C. Conine, Oliver J. Rando, Fengyun Sun, Ryan W. Serra, Carolina Galan

Publikováno v: PLoS Genetics, Vol 17, Iss 3, p e1009416 (2021)
PLoS Genetics

Beyond the haploid genome, mammalian sperm carry a payload of epigenetic information with the potential to modulate offspring phenotypes. Recent studies show that the small RNA repertoire of sperm is remodeled during post-testicular maturation in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d53190ba4184d79600d43685ca0c28d
https://doaj.org/article/14b27601fe0b45368ddc484dd0ae983e

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

Autor: Oliver J. Rando, Fengyun Sun, Emiliano P. Ricci, Clémence Belleannée, Lucas Fauquier, Manuel Garber, Ryan W. Serra, Ana Bošković, Xin Zhiguo Li, Xin Y. Bing, Benjamin R. Carone, Lina Song, Craig C. Mello, Melissa J. Moore, Alper Kucukural, Alan G. Derr, Jeremy M. Shea, Robert Sullivan, Colin C. Conine, Upasna Sharma

Publikováno v: Science
Science, 2016, 351 (6271), pp.391-396. ⟨10.1126/science.aad6780⟩
Science, American Association for the Advancement of Science, 2016, 351 (6271), pp.391-396. ⟨10.1126/science.aad6780⟩

Offspring affected by sperm small RNAs Paternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests the involvement of epigenetic pathways, the mechanisms remains unclear. Two studies now show t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc388e023218bab5f4f4ff0f5856dfd6
https://hal.science/hal-02444484/document

Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4

Autor: Min Peng, Panagiotis A. Konstantinopoulos, Shawna Guillemette, Janelle A. Hayes, Michael R. Green, Sharon B. Cantor, Ryan W. Serra

Hereditary cancers derive from gene defects that often compromise DNA repair. Thus, BRCA-associated cancers are sensitive to DNA-damaging agents such as cisplatin. The efficacy of cisplatin is limited, however, by the development of resistance. One c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9075fb04a7076b1f7dff67f52a0cb1
https://europepmc.org/articles/PMC4358401/

Senescence induction in human fibroblasts and hematopoietic progenitors by leukemogenic fusion proteins

Autor: Arvindhan Nagarajan, Xiaochun Zhu, Narendra Wajapeyee, Ryan W. Serra, Shu-Zong Wang, Michael R. Green, Peter D. Solomon

Hematologic malignancies are typically associated with leukemogenic fusion proteins, which are required to maintain the oncogenic state. Previous studies have shown that certain oncogenes that promote solid tumors, such as RAS and BRAF, can induce se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437a4d215ae8f62cffc9721a4cadc8f8
https://europepmc.org/articles/PMC2890151/