Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ryan W. O'Meara"'
Autor:
Matías Alvarez-Saavedra, Yves De Repentigny, Doo Yang, Ryan W. O’Meara, Keqin Yan, Lukas E. Hashem, Lemuel Racacho, Ilya Ioshikhes, Dennis E. Bulman, Robin J. Parks, Rashmi Kothary, David J. Picketts
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 862-875 (2016)
Exercise has been argued to enhance cognitive function and slow progressive neurodegenerative disease. Although exercise promotes neurogenesis, oligodendrogenesis and adaptive myelination are also significant contributors to brain repair and brain he
Externí odkaz:
https://doaj.org/article/9b6b65d29dbe477783fc4f4ada236722
Autor:
Lukas E. Hashem, Yves De Repentigny, Rashmi Kothary, Ilya Ioshikhes, David J. Picketts, Robin J. Parks, Matías Alvarez-Saavedra, Ryan W. O'Meara, Lemuel Racacho, Dennis E. Bulman, Keqin Yan, Doo Yang
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 862-875 (2016)
Indexación: Web of Science Exercise has been argued to enhance cognitive function and slow progressive neurodegenerative disease. Although exercise promotes neurogenesis, oligodendrogenesis and adaptive myelination are also significant contributors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c1432dabd803f1a3a62708108ed744
https://pubmed.ncbi.nlm.nih.gov/27732860
https://pubmed.ncbi.nlm.nih.gov/27732860
Publikováno v:
Journal of Signal Transduction
Multiple sclerosis is characterized by repeated demyelinating attacks of the central nervous system (CNS) white matter tracts. To tailor novel therapeutics to halt or reverse disease process, we require a better understanding of oligodendrocyte biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01ffc4daf260e84225c5266775727f6
https://doi.org/10.1155/2011/354091
https://doi.org/10.1155/2011/354091
Publikováno v:
Journal of neurochemistry. 136(3)
Integrin-linked kinase (ILK), a focal adhesion protein, brokers the link between cytoskeleton, cell membrane, and extracellular environment. Here, we demonstrate a role for ILK in laminin-2-mediated adhesion in primary murine oligodendrocytes (OLs) -
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed745d22e773fb15b013c548f1f020e
https://pubmed.ncbi.nlm.nih.gov/26614167
https://pubmed.ncbi.nlm.nih.gov/26614167
Autor:
Marc-Olivier Deguise, Rashmi Kothary, John-Paul Michalski, Sarah E. Cummings, Emily McFall, Ryan W. O'Meara, Sabrina Gibeault, Yves De Repentigny
Publikováno v:
Human Molecular Genetics. :ddw385
The childhood neurodegenerative disease spinal muscular atrophy (SMA) is caused by loss-of-function mutations or deletions in the Survival Motor Neuron 1 (SMN1) gene resulting in insufficient levels of survival motor neuron (SMN) protein. Classically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38819a46348de37c227bfe1aacd3881a
https://doi.org/10.1093/hmg/ddw385
https://doi.org/10.1093/hmg/ddw385
Autor:
Kevin G. Young, Samantha F. Kornfeld, Rashmi Kothary, Anisha Lynch-Godrei, Andrew Ferrier, Yves De Repentigny, Sabrina Gibeault, Kunal Bhanot, Tadasu Sato, Ryan W. O'Meara
A newly identified lethal form of hereditary sensory and autonomic neuropathy (HSAN), designated HSAN-VI, is caused by a homozygous mutation in the bullous pemphigoid antigen 1 (BPAG1)/dystonin gene (DST). The HSAN-VI mutation impacts all major neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77434f8b0d47a37e812894c768be79a9
https://europepmc.org/articles/PMC3990168/
https://europepmc.org/articles/PMC3990168/
Autor:
Peter Rippstein, Rashmi Kothary, Ryan W. O'Meara, Kunal Bhanot, Carrie L. Anderson, John-Paul Michalski
Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. Here, through the use of conditional knock-out mice, we demonstrate a requirement for ILK in oligodendrocyte different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2283cfa1c12e35235e4d5c3f7eb0385
https://europepmc.org/articles/PMC6619710/
https://europepmc.org/articles/PMC6619710/
Autor:
Tadasu Sato, Sheng T. Hou, Susan X. Jiang, Yves De Repentigny, Rashmi Kothary, Ryan W. O'Meara, Scott D. Ryan, Andrew Ferrier
Publikováno v:
Molecular Biology of the Cell
ETOC: The diverging contributions of the cytoskeletal linker proteins dystonin-a1 and dystonin-a2 to pathology in dystonia musculorum are largely unknown. Sensory neurodegeneration results primarily from the loss of the dystonin-a2 isoform, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6526f59534762b328fdb1f9f2dc2215
https://doi.org/10.1091/mbc.e11-06-0573
https://doi.org/10.1091/mbc.e11-06-0573
Publikováno v:
Journal of Visualized Experiments : JoVE
Identifying the molecular mechanisms underlying OL development is not only critical to furthering our knowledge of OL biology, but also has implications for understanding the pathogenesis of demyelinating diseases such as Multiple Sclerosis (MS). Cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321499718517f353bf8eac9cb6ded76d
https://doi.org/10.3791/3324
https://doi.org/10.3791/3324
Autor:
Carin Christou, Rashmi Kothary, Robin J. Parks, Milagros Risco Quiroz, Adam C. Smith, Robert M. Lanthier, Karen L. Powell, Ian A. J. Lorimer, Ryan W. O'Meara, Kathy L. Poulin
Publikováno v:
Journal of virology. 84(19)
Adenovirus (Ad) vectors are the most commonly used system for gene therapy applications, due in part to their ability to infect a wide array of cell types and tissues. However, many therapies would benefit from the ability to target the Ad vector onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a6854337963e1eca2571ab0272e6c5
https://pubmed.ncbi.nlm.nih.gov/20631131
https://pubmed.ncbi.nlm.nih.gov/20631131