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of 10
pro vyhledávání: '"Ryan W. Huyck"'
Autor:
Vijay Gottipati, Anna Marley, William L. McPheat, Bronson A. Haynes, Lindsey Glenn, Jerry L. Nadler, Göran I. Hansson, Ryan W. Huyck, Anca D. Dobrian
Publikováno v:
Prostaglandins & Other Lipid Mediators. 136:23-32
The 12-lipoxygenase (12LO) pathway is a promising target to reduce islet dysfunction, adipose tissue (AT) inflammation and insulin resistance. Optimal pre-clinical models for the investigation of selective12LO inhibitors in this context have not yet
Autor:
Joshua M. Turner, Vanessa L. Correll, Allison Mathiesen, Nektarios Barabutis, Eric J. Lehrer, Ryan W. Huyck, Anca D. Dobrian, Li Fang Yang, O. John Semmes, Bronson A. Haynes, William McPheat
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Endothelial cells (EC) in obese adipose tissue (AT) are exposed to a chronic proinflammatory environment that may induce a mesenchymal-like phenotype and altered function. The objective of this study was to establish whether endothelial-to
Autor:
Catherine H. Bianchi, Andrew D. Halleran, Margaret S. Saha, Mark E. Pownall, Sudip Paudel, Molly J. Hillenbrand, Ryan W. Huyck, Claire E. Tocheny, Grace E. Solini
Publikováno v:
Developmental biology
As an essential feature of development, robustness ensures that embryos attain a consistent phenotype despite genetic and environmental variation. The growing number of examples demonstrating that embryos can mount a compensatory response to germline
Autor:
Ryan W. Huyck, Avennette Pinto, Ashley J James, Omnia U Gaafar, Bronson A. Haynes, Anca D. Dobrian, Meghan E Carter, Marjorie Day
Publikováno v:
Journal of Visualized Experiments.
Obesity is accompanied by an extensive remodeling of adipose tissue primarily via adipocyte hypertrophy. Extreme adipocyte growth results in a poor response to insulin, local hypoxia, and inflammation. By stimulating the differentiation of functional
Autor:
Brian A. Rabe, Margaret S. Saha, Andrew D. Halleran, Morgan Sehdev, Ryan W. Huyck, Cheyenne C. Williams
Publikováno v:
Gene Expression Patterns. 17(1):38-44
The tweety family of genes encodes large-conductance chloride channels and has been implicated in a wide array of cellular processes including cell division, cell adhesion, regulation of calcium activity, and tumorigenesis, particularly in neuronal c
Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds
Autor:
Haree K. Pallera, Angela Pineros-Fernandez, Magdielis Gregory Rivera, Anca D. Dobrian, Brittany P. Lassiter, Ryan W. Huyck, Mary Ann Clements, Neel K. Krishna, Jerry L. Nadler, George T. Rodeheaver, Antoinette F. Hood, Kenji M. Cunnion, Patrick S. Cottler, Pamela S. Hair
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170500 (2017)
PLoS ONE, Vol 12, Iss 1, p e0170500 (2017)
Diabetic non-healing wounds are a major clinical problem. The mechanisms leading to poor wound healing in diabetes are multifactorial but unresolved inflammation may be a major contributing factor. The complement system (CS) is the most potent inflam
Autor:
Eric J. Lehrer, Ashley James, Ryan W. Huyck, Bronson A. Haynes, Anca D. Dobrian, Giann J Bhatt
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
The mechanisms underlying vascular dysfunction in adipose tissue (AT) in obesity are not clearly understood. Our hypothesis is that in response to pro-inflammatory cytokines (PIC) present in obese AT, endothelial cells (EC) can de-differentiate and a
Publikováno v:
Protein Expression and Purification. 85:86-93
The metal response element binding transcription factor-1 (MTF-1) is an important stress response, heavy metal detoxification, and zinc homeostasis factor in eukaryotic organisms from Drosophila to humans. MTF-1 transcriptional regulation is primaril
Publikováno v:
Molecular and cellular biology. 28(13)
Herein, the mechanisms of transactivation of gene expression by mouse metal response element-binding transcription factor 1 (MTF-1) were investigated. Evidence obtained from coimmunoprecipitation assays revealed that exposure of the cells to zinc res
Publikováno v:
Neurotoxicology and Teratology. :102-113
Methylmercury (MeHg) is a widespread environmental toxin that preferentially and adversely affects developing organisms. To investigate the impact of MeHg toxicity on the formation of the vertebrate nervous system at physiologically relevant concentr