Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ryan W. Feathers"'
Autor:
Wan-Hsin Lin, Ryan W. Feathers, Lisa M. Cooper, Laura J. Lewis-Tuffin, Jiaxiang Chen, Jann N. Sarkaria, Panos Z. Anastasiadis
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Glioblastomas (GBM) are aggressive tumors that lack effective treatments. Here, we show that the Rho family guanine nucleotide exchange factor Syx promotes GBM cell growth both in vitro and in orthotopic xenografts derived from patients with GBM. Gro
Externí odkaz:
https://doaj.org/article/88293167408845f6a8a970ef58fbb1c5
Autor:
Lindy J. Pence, Antonis Kourtidis, Ryan W. Feathers, Mary T. Haddad, Sotiris Sotiriou, Paul A. Decker, Aziza Nassar, Idris T. Ocal, Sejal S. Shah, Panos Z. Anastasiadis
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1275 (2021)
Inflammatory breast cancer is a highly aggressive form of breast cancer that forms clusters of tumor emboli in dermal lymphatics and readily metastasizes. These cancers express high levels of E-cadherin, the major mediator of adherens junctions, whic
Externí odkaz:
https://doaj.org/article/e9a67536008f4bb3966bc3def37f0a12
Autor:
Louis Y El Khoury, Wan Hsin Lin, James B Smadbeck, Michael T Barrett, Dorsay Sadeghian, Alexa F McCune, Giannoula Karagouga, John C Cheville, Faye R Harris, Lindsey M Kinsella, Ryan W Feathers, Janet L Schafer Klein, Marina RS Walther-Antonio, Sarah H Johnson, Alan R Penheiter, Giuseppe Cucinella, Gabriella Schivardi, Aditya Bhagwate, Mitesh J Borad, Aaron S Mansfield, Stephen J Murphy, Andrea Mariani, George Vasmatzis, Panos Z Anastasiadis, Saravut J Weroha, Alyssa M Larish
Publikováno v:
Epigenomics. 15:283-292
This work examines differences in chromatin accessibility, methylation, and response to DNA hypomethylating agents between mismatch repair-deficient and non-mismatch repair-deficient endometrial cancer. Next-generation sequencing of a stage 1B, grade
Autor:
Jann N. Sarkaria, William F. Elmquist, Nathalie Y.R. Agar, Panos Z. Anastasiadis, Ian F. Parney, Aaron J. Johnson, Gaspar J. Kitange, Jeanette E. Eckel-Passow, Paul A Decker, Shulan Tian, James Watters, Laurent Debussche, Cedric Barriere, Fang Jin, Karen E. Parrish, Ann C. Mladek, Isabelle Meaux, Rachael A. Vaubel, Ryan W. Feathers, Shuangling Zhang, David Calligaris, Daniel J. Ma, Minjee Kim
Fig. S1: MDM2 transcript expression. RNA extracted from flank tumor xenografts from 51 PDX models was assessed by qRT-PCR for MDM2 expression in pooled triplicate samples and compared to expression in normal brain (NB). Fig. S2: MDM2 Amplification in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4d4bccac2b614bb5347cc66708c7b1
https://doi.org/10.1158/1535-7163.22505115
https://doi.org/10.1158/1535-7163.22505115
Autor:
Jann N. Sarkaria, William F. Elmquist, Nathalie Y.R. Agar, Panos Z. Anastasiadis, Ian F. Parney, Aaron J. Johnson, Gaspar J. Kitange, Jeanette E. Eckel-Passow, Paul A Decker, Shulan Tian, James Watters, Laurent Debussche, Cedric Barriere, Fang Jin, Karen E. Parrish, Ann C. Mladek, Isabelle Meaux, Rachael A. Vaubel, Ryan W. Feathers, Shuangling Zhang, David Calligaris, Daniel J. Ma, Minjee Kim
Controversy exists surrounding whether heterogeneous disruption of the blood–brain barrier (BBB), as seen in glioblastoma (GBM), leads to adequate drug delivery sufficient for efficacy in GBM. This question is especially important when using potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1456b2133a588e38554e1ad333e22fed
https://doi.org/10.1158/1535-7163.c.6537957.v1
https://doi.org/10.1158/1535-7163.c.6537957.v1
Autor:
Nadine Norton, Pooja P Advani, Daniel J Serie, Xochiquetzal J Geiger, Brian M Necela, Bianca C Axenfeld, Jennifer M Kachergus, Ryan W Feathers, Jennifer M Carr, Julia E Crook, Alvaro Moreno-Aspitia, Panos Z Anastasiadis, Edith A Perez, E Aubrey Thompson
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153411 (2016)
Invasive lobular carcinoma (ILC) comprises approximately ~10-20% of breast cancers. In general, multifocal/multicentric (MF/MC) breast cancer has been associated with an increased rate of regional lymph node metastases. Tumor heterogeneity between fo
Externí odkaz:
https://doaj.org/article/9f82f46e2f784e179860013a8cb491d0
Autor:
Stephen J. Murphy, Minetta C. Liu, Faye R. Harris, Sarah H. Johnson, George Vasmatzis, Farhad Kosari, Ryan W. Feathers, Mitesh J. Borad, James B. Smadbeck, Sowjanya Reganti, Janet L. Schaefer Klein, Lin Yang, E. Aubrey Thompson, John Cheville, Panos Z. Anastasiadis
Publikováno v:
Mayo Clinic proceedings
Objective To select optimal therapies based on the detection of actionable genomic alterations in tumor samples is a major challenge in precision medicine. Methods We describe an effective process (opened December 1, 2017) that combines comprehensive
Autor:
Wan-Hsin Lin, Ryan W. Feathers, Lisa M. Cooper, Laura J. Lewis-Tuffin, Jann N. Sarkaria, Panos Z. Anastasiadis
Glioblastomas (GBM) are aggressive tumors that lack effective treatments. Here, we show that the Rho family guanine nucleotide exchange factor Syx promotes GBM cell growth both in vitro and in orthotopic GBM patient-derived xenografts. Growth defects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb8e567738f7515eba64b7436cbed53
https://doi.org/10.1101/2021.12.03.469255
https://doi.org/10.1101/2021.12.03.469255
Autor:
George Vasmatzis, J Weroha, Andrea Mariani, Ryan W. Feathers, W-H Lin, Leila A. Jones, Alexa McCune, Stephen J. Murphy, J Lynch, Alyssa Larish, Aaron S. Mansfield, Panos Z. Anastasiadis, Matthew S. Block, Faye R. Harris, Giannoula Karagouga, A Kumar, S Sotiriou, James B. Smadbeck, John C. Cheville
Publikováno v:
E-Posters.
Autor:
Ariana Mostafa, Alvaro G. Hernandez, C. L. Wright, Jenny Drnevich, Anurup Ganguli, Jacob Berger, Vahid Faramarzi, Andrew M. Smith, Rashid Bashir, Phuong Le, George Vasmatzis, Olaoluwa O. Adeniba, Panos Z. Anastasiadis, Yongdeok Kim, Wan-Hsin Lin, Ryan W. Feathers, C. Saavedra, Karla P. Ramos-Cruz, Farhad Kosari, G. J. Pagan Diaz
Publikováno v:
Science Advances
Tiny silicon microchip–based high-throughput hanging drop arrays allow drug screening and geometric control.
Existing three-dimensional (3D) culture techniques are limited by trade-offs between throughput, capacity for high-resolution imaging
Existing three-dimensional (3D) culture techniques are limited by trade-offs between throughput, capacity for high-resolution imaging