Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Ryan W. Clinton"'
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Affinity Purification and Functional Characterization of Dynamin-Related Protein 1
Autor: Ryan W. Clinton, Jason A. Mears, Brianna L. Bauer
Publikováno v: Methods in Molecular Biology ISBN: 9781071606759
Methods Mol Biol
Purification of dynamin-related proteins is complicated by their oligomeric tendencies. In this chapter, we describe an established purification regime to isolate the mitochondrial fission protein Drp1 using bacterial expression. Key attributes of dy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7596e5c947ead0ac0a9bd480cc72ef15
https://doi.org/10.1007/978-1-0716-0676-6_4
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3
Steric interference from intrinsically disordered regions controls dynamin-related protein 1 self-assembly during mitochondrial fission
Autor: Natalia Stepanyants, Rajesh Ramachandran, Ryan W. Clinton, Bridget Kennedy, Emily Jue Wang, Xin Qi, Bin Lu, Patrick J. Macdonald, Jason A. Mears, Daniel R. McHugh
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-21 (2018)
Scientific Reports
The self-assembling, mechanoenzymatic dynamin superfamily GTPase, dynamin-related protein 1 (Drp1), catalyzes mitochondrial and peroxisomal fission. Distinct intrinsically disordered regions (IDRs) in Drp1 substitute for the canonical pleckstrin homo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855f1b5ff02d99fbea69b5872292e91b
https://doi.org/10.1038/s41598-018-29001-9
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5
Cryo-EM Studies of Drp1 Reveal Cardiolipin Interactions that Activate the Helical Oligomer
Autor: Christopher A. Francy, Chris Fröhlich, Ryan W. Clinton, Colleen Murphy, Jason A. Mears
Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Dynamins are mechano-chemical GTPases involved in the remodeling of cellular membranes. In this study, we have investigated the mechanism of dynamin-related protein 1 (Drp1), a key mediator of mitochondrial fission. To date, it is unclear how Drp1 as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6698c933d58cfae1cddf3e3b13ad3a96
https://pubmed.ncbi.nlm.nih.gov/28878368
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6
Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants
Autor: Huifang Xu, Angela Paul, Leo S. Payne, Scott Gridley, Edward A. Esposito, Maciej T. Luczynski, Paul H. Huang, Francis Chang, Birgit Leitinger, Ryan W. Clinton, Leo Kei Iwai, Kristen M. Naegle
Publikováno v: Biochemical Journal
Collagen is an important extracellular matrix component that directs many fundamental cellular processes including differentiation, proliferation and motility. The signalling networks driving these processes are propagated by collagen receptors such
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c387521eaf5d495273f18ce098d2aa9
http://europepmc.org/articles/PMC3893797
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7
Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro
Autor: Jason A. Mears, Ryan W. Clinton
Publikováno v: Journal of Visualized Experiments.
Studies of integral membrane proteins in vitro are frequently complicated by the presence of a hydrophobic transmembrane domain. Further complicating these studies, reincorporation of detergent-solubilized membrane proteins into liposomes is a stocha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1299d1cf61c797d0c5eec49e40aa2965
https://doi.org/10.3791/54971-v
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