Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ryan V. Harkless"'
Autor:
Eva Tonsing-Carter, Kyle M. Hernandez, Caroline R. Kim, Ryan V. Harkless, Alyce Oh, Kathleen R. Bowie, Diana C. West-Szymanski, Mayra A. Betancourt-Ponce, Bradley D. Green, Ricardo R. Lastra, Gini F. Fleming, Sarat Chandarlapaty, Suzanne D. Conzen
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-15 (2019)
Abstract Background Non-ER nuclear receptor activity can alter estrogen receptor (ER) chromatin association and resultant ER-mediated transcription. Consistent with GR modulation of ER activity, high tumor glucocorticoid receptor (GR) expression corr
Externí odkaz:
https://doaj.org/article/15ee561df07048839912c4364c12edf6
Autor:
Suzanne D. Conzen, Balázs Györffy, Gini F. Fleming, Liewei Wang, Krishna R. Kalari, Matthew P. Goetz, Judy C. Boughey, Geoffrey L. Greene, Larischa de Wet, Caroline R. Kim, Sarah C. Styke, Charles F. Pierce, Maxwell N. Skor, Ryan V. Harkless, Kathleen R. Bowie, Kevin J. Thompson, Jason P. Sinnwell, Ricardo R. Lastra, David J. Hosfield, D. Nesli Dolcen, Eva Y. Tonsing-Carter, Masha Kocherginsky, Diana C. West
Purpose: Although high glucocorticoid receptor (GR) expression in early-stage estrogen receptor (ER)-negative breast cancer is associated with shortened relapse-free survival (RFS), how associated GR transcriptional activity contributes to aggressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e027a72cce381dcf4648a09af62b3f
https://doi.org/10.1158/1078-0432.c.6525818.v1
https://doi.org/10.1158/1078-0432.c.6525818.v1
Autor:
Suzanne D. Conzen, Balázs Györffy, Gini F. Fleming, Liewei Wang, Krishna R. Kalari, Matthew P. Goetz, Judy C. Boughey, Geoffrey L. Greene, Larischa de Wet, Caroline R. Kim, Sarah C. Styke, Charles F. Pierce, Maxwell N. Skor, Ryan V. Harkless, Kathleen R. Bowie, Kevin J. Thompson, Jason P. Sinnwell, Ricardo R. Lastra, David J. Hosfield, D. Nesli Dolcen, Eva Y. Tonsing-Carter, Masha Kocherginsky, Diana C. West
Graphical images of GR ChIP-seq peaks in regions flanking the TSSs of the n=31 GR putative direct target genes contained in the GRsig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b5f65c71a301a35e8499846e2f1e36
https://doi.org/10.1158/1078-0432.22464830
https://doi.org/10.1158/1078-0432.22464830
Autor:
Suzanne D. Conzen, Balázs Györffy, Gini F. Fleming, Liewei Wang, Krishna R. Kalari, Matthew P. Goetz, Judy C. Boughey, Geoffrey L. Greene, Larischa de Wet, Caroline R. Kim, Sarah C. Styke, Charles F. Pierce, Maxwell N. Skor, Ryan V. Harkless, Kathleen R. Bowie, Kevin J. Thompson, Jason P. Sinnwell, Ricardo R. Lastra, David J. Hosfield, D. Nesli Dolcen, Eva Y. Tonsing-Carter, Masha Kocherginsky, Diana C. West
Supplementary Figures, Materials and Methods, and Descriptions of Supplementary files Supplementary Figure 1. Ligand displacement of GC from GR LBD. Supplementary Figure 2. C297 monotherapy is not cytotoxic in vitro or in vivo. Supplementary Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e48db567b458213296fced45e7f535
https://doi.org/10.1158/1078-0432.22464827
https://doi.org/10.1158/1078-0432.22464827
Autor:
Suzanne D. Conzen, Balázs Györffy, Gini F. Fleming, Liewei Wang, Krishna R. Kalari, Matthew P. Goetz, Judy C. Boughey, Geoffrey L. Greene, Larischa de Wet, Caroline R. Kim, Sarah C. Styke, Charles F. Pierce, Maxwell N. Skor, Ryan V. Harkless, Kathleen R. Bowie, Kevin J. Thompson, Jason P. Sinnwell, Ricardo R. Lastra, David J. Hosfield, D. Nesli Dolcen, Eva Y. Tonsing-Carter, Masha Kocherginsky, Diana C. West
Patient and tumor prognostic values of study cohorts and a flow chart of the study design.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dd9d606af620d82f77058e6aa0a0bf
https://doi.org/10.1158/1078-0432.22464836.v1
https://doi.org/10.1158/1078-0432.22464836.v1
Autor:
Mayra A. Betancourt-Ponce, Diana C. West-Szymanski, Suzanne D. Conzen, Alyce Oh, Kyle M. Hernandez, Caroline R. Kim, Ricardo R. Lastra, Kathleen R. Bowie, Eva Tonsing-Carter, Bradley Green, Sarat Chandarlapaty, Ryan V. Harkless, Gini F. Fleming
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-15 (2019)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Background Non-ER nuclear receptor activity can alter estrogen receptor (ER) chromatin association and resultant ER-mediated transcription. Consistent with GR modulation of ER activity, high tumor glucocorticoid receptor (GR) expression correlates wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886a860a906146eb6f04f7ae5d6d32af
http://link.springer.com/article/10.1186/s13058-019-1164-6
http://link.springer.com/article/10.1186/s13058-019-1164-6
Autor:
Suzanne D. Conzen, Kathleen R. Bowie, Eva Tonsing-Carter, Kyle M. Hernandez, Ryan V. Harkless, Diana C. West
Publikováno v:
Cancer Research. 77:P3-05
Early-stage ER+ breast cancer with high tumor glucocorticoid receptor (GR) expression is associated with improved long term relapse-free survival compared to tumors with low GR expression. In addition, activation of GR inhibits estradiol-mediated ER+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb34bb7d3f2bf88c7e6ea8dbe426c6a8
https://doi.org/10.1158/1538-7445.sabcs16-p3-05-09
https://doi.org/10.1158/1538-7445.sabcs16-p3-05-09
Autor:
Diana C. West, D.N. Dolcen, David J. Hosfield, Ryan V. Harkless, Russell Z. Szmulewitz, Eva Tonsing-Carter, Geoffrey L. Greene, Suzanne D. Conzen, T. Long
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b6dfa8a289e15ae28b6ba2e19a6474c
https://doi.org/10.1530/endoabs.54.is10
https://doi.org/10.1530/endoabs.54.is10
Autor:
Jason P. Sinnwell, Gini F. Fleming, Caroline R. Kim, Ricardo R. Lastra, Ryan V. Harkless, David J. Hosfield, Diana C. West, Kevin J. Thompson, Krishna R. Kalari, Balazs Gyorffy, Judy C. Boughey, Charles F. Pierce, Maxwell N. Skor, Eva Tonsing-Carter, Masha Kocherginsky, Kathleen R. Bowie, Matthew P. Goetz, Larischa de Wet, D. Nesli Dolcen, Geoffrey L. Greene, Liewei Wang, Sarah C. Styke, Suzanne D. Conzen
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 24(14)
Purpose: Although high glucocorticoid receptor (GR) expression in early-stage estrogen receptor (ER)-negative breast cancer is associated with shortened relapse-free survival (RFS), how associated GR transcriptional activity contributes to aggressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59786039c050eed56f12b0e4cf2482bc
https://pubmed.ncbi.nlm.nih.gov/29636357
https://pubmed.ncbi.nlm.nih.gov/29636357
Autor:
Suzanne D. Conzen, Caroline R. Kim, Gini F. Fleming, Deniz N. Dolcen, Eva Tonsing-Carter, Kathleen R. Bowie, Ryan V. Harkless
Publikováno v:
Cancer Research. 78:2541-2541
Background: A recent effort to distinguish early-stage TNBC based on outcome and to expose driver pathways using gene profiling/cluster analysis divided TNBC into four subtypes- basal-like, mesenchymal, immunomodulatory, and luminal androgen receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e07a5abfc329ab1ed66947cc4d25102
https://doi.org/10.1158/1538-7445.am2018-2541
https://doi.org/10.1158/1538-7445.am2018-2541