Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Ryan Urak"'
Autor:
Ryan Urak, Saghar Pahlavanneshan, Brenna Gittins, Ryotaro Nakamura, John A. Zaia, John H. Baird, Mary C. Clark, Stephen J. Forman, Xiuli Wang
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Not available.
Externí odkaz:
https://doaj.org/article/5ab30dc22dbb477c8947a229c3b6269b
Autor:
Dennis Awuah, Lin Li, Lindsay Williams, Ryan Urak, Maciej Kujawski, Stephen J. Forman, John E. Shively, Xiuli Wang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Bispecific T cell engaging antibodies (bsAbs) have emerged as novel and powerful therapeutic agents for redirecting T cells towards antigen-specific tumor killing. The cell surface glycoprotein and SLAM family member, CS1, exhibits stable an
Externí odkaz:
https://doaj.org/article/d8b4c88f6fe24aa3a0c46cae4a0598c2
Autor:
Stephen J Forman, Xiuli Wang, Ryan Urak, John Baird, Mary C Clark, John Zaia, Ryotaro Nakamura, Saghar Pahlavanneshan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/434e7441c84040f1a608c471de9b43f3
Autor:
Min Guan, Laura Lim, Leo Holguin, Tianxu Han, Vibhuti Vyas, Ryan Urak, Aaron Miller, Diana L. Browning, Liliana Echavarria, Shasha Li, Shirley Li, Wen-Chung Chang, Tristan Scott, Paul Yazaki, Kevin V. Morris, Angelo A. Cardoso, M. Suzette Blanchard, Virginia Le Verche, Stephen J. Forman, John A. Zaia, John C. Burnett, Xiuli Wang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 344-359 (2022)
T cells engineered to express HIV-specific chimeric antigen receptors (CARs) represent a promising strategy to clear HIV-infected cells, but to date have not achieved clinical benefits. A likely hurdle is the limited T cell activation and persistence
Externí odkaz:
https://doaj.org/article/c35d7761f02247f9aa1379d906dc6325
Single-cell analysis by mass cytometry reveals CD19 CAR T cell spatiotemporal plasticity in patients
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The adaptive T cell immune response requires cellular plasticity to generate distinct subsets with diverse functional and migratory capacities. Studies of CAR T cells have primarily focused on a limited number of phenotypic markers in blood, represen
Externí odkaz:
https://doaj.org/article/6ffbd62bb6cf438c8703bb53592feabb
Autor:
Ryan Urak, Brenna Gittins, Citradewi Soemardy, Nicole Grepo, Lior Goldberg, Madeleine Maker, Galina Shevchenko, Alicia Davis, Shirley Li, Tristan Scott, Kevin V. Morris, Stephen J. Forman, Xiuli Wang
Publikováno v:
Cancers, Vol 15, Iss 10, p 2848 (2023)
Short hairpin RNAs (shRNAs) have emerged as a powerful tool for gene knockdown in various cellular systems, including chimeric antigen receptor (CAR) T cells. However, the elements of shRNAs that are crucial for their efficacy in developing shRNA-con
Externí odkaz:
https://doaj.org/article/b5accecf042a46e989ebd1044beff2b1
Autor:
Stephen J Forman, Xiuli Wang, Ryan Urak, Miriam Walter, Min Guan, Tianxu Han, Vibhuti Vyas, Sheng-Hsuan Chien, Brenna Gittins, Mary C Clark, Sally Mokhtari, Angelo Cardoso, Don J Diamond, John Zaia, Ryotaro Nakamura
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/3a1427b2df1e43c0b87e330a814dd039
Autor:
Saul J. Priceman, Ethan A. Gerdts, Dileshni Tilakawardane, Kelly T. Kennewick, John P. Murad, Anthony K. Park, Brook Jeang, Yukiko Yamaguchi, Xin Yang, Ryan Urak, Lihong Weng, Wen-Chung Chang, Sarah Wright, Sumanta Pal, Robert E. Reiter, Anna M. Wu, Christine E. Brown, Stephen J. Forman
Publikováno v:
OncoImmunology, Vol 7, Iss 2 (2018)
Advancing chimeric antigen receptor (CAR)-engineered adoptive T cells for the treatment of solid cancers is a major focus in the field of immunotherapy, given impressive recent clinical responses in hematological malignancies. Prostate cancer may be
Externí odkaz:
https://doaj.org/article/629ee7d73f44415b8d4d8a86e5399e0c
Autor:
Christine E. Brown, Stephen J. Forman, Xiuli Wang, Ryan Urak, Renate Starr, David K. Ann, Yue Qi, Brenda Aguilar, Cheng-Fu Kuo, Joseph R. Pecoraro, Dongrui Wang, Xin Yang, Robyn A. Wong, Darya Alizadeh
Supp Fig 1 Compares IL2 alone to manufacturing platform. Supp Fig 2 Product post-enrichment. Supp Fig 3 Additional characterization of IL2 and IL15 cultured CAR-T cells. Supp Fig 4 Heat map comparing CD4 gene expression differences in IL2 and IL15 cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3d552e9c4d51afd712cc3efe930c70
https://doi.org/10.1158/2326-6066.22542318
https://doi.org/10.1158/2326-6066.22542318
Autor:
Stephen J. Forman, Christine E. Brown, Tanya Siddiqi, Leslie Popplewell, Mary C. Clark, Sandra H. Thomas, Lihua E. Budde, Larry W. Kwak, Hong Qin, Saul J. Priceman, Jianying Zhang, Xiwei Wu, Jinhui Wang, Lu Yang, N. Achini Bandara, Aniee Sarkissian, Alfonso Brito, Brenda Aguilar, Wen-Chung Chang, Vibhuti Vyas, Laura Lim, Miriam Walter, Lihong Weng, Ryan Urak, Christian Huynh, Xiuli Wang
Lymphomas with central nervous system (CNS) involvement confer a worse prognosis than those without CNS involvement, and patients currently have limited treatment options. T cells genetically engineered with CD19-targeted chimeric antigen receptors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3556227d6d0bf66deaa44d3d6fbcc271
https://doi.org/10.1158/2326-6066.c.6550309.v1
https://doi.org/10.1158/2326-6066.c.6550309.v1