Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Ryan Turncliff"'
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Abstract OT3-04-01: A Phase 3 study evaluating ovarian suppression following three-month leuprolide acetate in combination with endocrine therapy in premenopausal subjects with HR+, HER2-negative breast cancer (OVELIA)
Autor: Ryan Turncliff, Erika Hamilton, Kerlin Lynch, Stuart N. Atkinson
Publikováno v: Cancer Research. 83:OT3-04
Background: In US clinical practice, GnRH agonists are widely used to suppress ovarian function in pre/perimenopausal patients with breast cancer that is moderate-to high-risk for recurrence. Despite extensive use of leuprolide acetate (LA) for ovari
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40b135db5056a7b78749170dfc133476
https://doi.org/10.1158/1538-7445.sabcs22-ot3-04-01
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2
Use of Remifentanil in a Novel Clinical Paradigm to Characterize Onset and Duration of Opioid Blockade by Samidorphan, a Potent μ-Receptor Antagonist
Autor: Megan J. Shram, Ryan Turncliff, Elliot Ehrich, Bernard L. Silverman, Edward M. Sellers
Publikováno v: Journal of Clinical Psychopharmacology
A novel clinical study design was used to evaluate the blockade of a selective short-acting μ-opioid agonist (remifentanil) in 24 opioid-experienced subjects. Samidorphan (3-carboxamido-4-hydroxynaltrexone) is a novel opioid modulator with μ-antago
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5be3d6cddc7d4c280ded4a4b1a4f31f
https://doi.org/10.1097/jcp.0000000000000320
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3
Evaluation of Opioid Modulation in Major Depressive Disorder
Autor: E. Fernandez, Maurizio Fava, Elliot Ehrich, Reese T. Jones, Ryan Turncliff, Richard Leigh-Pemberton, Yangchun Du
Publikováno v: Neuropsychopharmacology
Although opioids have known antidepressant activity, their use in major depressive disorder (MDD) has been greatly limited by risk of abuse and addiction. Our aim was to determine whether opioid modulation achieved through a combination of a μ-opioi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c8e17dc1ba87c0c7f1d1ecfbdedab8
http://europepmc.org/articles/PMC4397403
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5
Relative bioavailability and safety of aripiprazole lauroxil, a novel once-monthly, long-acting injectable atypical antipsychotic, following deltoid and gluteal administration in adult subjects with schizophrenia
Autor: Yangchun Du, Elliot Ehrich, Ryan Turncliff, Marjie L. Hard, Robert Risinger
Publikováno v: Schizophrenia Research. 159:404-410
Aripiprazole lauroxil is a linker lipid ester of aripiprazole for extended-release intramuscular (IM) injection. This multicenter, randomized, open-label study evaluated the pharmacokinetics (PK), relative bioavailability, and tolerability of a singl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cea8dc1e58523568cdfe543f3a462f
https://doi.org/10.1016/j.schres.2014.09.021
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6
Exceptionally high decarboxylation rate of a primary aliphatic acyloxy radical determined by radical product yield analysis and quantitative 1 H-CIDNP spectroscopy
Autor: Ryan Turncliff, Justin Sodano, Lev R. Ryzhkov, Alicia M. Fraind, Teri Fox
Publikováno v: Journal of Physical Organic Chemistry. 24:809-820
Symmetrical (RCO2CO2R; R = XCH2CH2) and asymmetrical (RCO2CO2R′; R = C9H19CH2CH2, R′ = CH3 or m-ClC6H4) primary diacyl peroxides were thermally decomposed under different conditions to analyze the decarboxylation rates of the thermally generated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b99a14eea739c3d8419ffd48a9eb842
https://doi.org/10.1002/poc.1836
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7
Route of administration affects the ability of naltrexone to reduce amphetamine-potentiated brain stimulation reward in rats
Autor: Ryan Turncliff, Reginald L. Dean, Kristina Kriksciukaite, Krystal S. O’Neill, Irina Ostrovsky‐Day, Mark S. Todtenkopf, Daniel R. Deaver
Publikováno v: Addiction Biology. 14:408-418
Opioid receptor antagonism has been shown to attenuate behavioral and neurochemical effects of amphetamine in humans and rodents. The effects of acute (oral or subcutaneous) or extended-release naltrexone (XR-NTX) were tested on the reward-enhancing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ab1ae72c736237b523fb583b05e99c
https://doi.org/10.1111/j.1369-1600.2009.00161.x
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8
Single- and multiple-dose pharmacokinetics of samidorphan, a novel opioid antagonist, in healthy volunteers
Autor: Ryan Turncliff, Elliot Ehrich, Bernard L. Silverman, Lauren DiPetrillo
Publikováno v: Clinical therapeutics. 37(2)
Samidorphan (3-carboxamido-4-hydroxy naltrexone) is a novel opioid receptor antagonist that is currently in clinical development. The oral dose pharmacokinetics, safety, and tolerability of samidorphan were evaluated in 2 double-blind, placebo-contro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4ee987f46cfc1b12f22931f55535a5
https://pubmed.ncbi.nlm.nih.gov/25456560
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9
Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats
Autor: Daniel R. Deaver, Reginald L. Dean, Ryan Turncliff, Jean M. Bidlack, David J. Eyerman, Mark S. Todtenkopf
Publikováno v: Pharmacology, biochemistry, and behavior. 100(3)
Naltrexone is a μ-opioid receptor antagonist that has been extensively studied for its ability to block the rewarding effects of ethanol. Opioid receptors are widely distributed within the gastrointestinal tract (GIT). Typically, naltrexone is admin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1643851e6b902e9c9e1f9c32d058d2
https://pubmed.ncbi.nlm.nih.gov/22056608
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