Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ryan Thwaites"'
Autor:
Stephanie Ascough, PhD, Pete Dayananda, MBChB, Mohini Kalyan, MSc, Seng Ung Kuong, MSc, Zoe Gardener, BSc, Emma Bergstrom, BSc, Suzanna Paterson, MbBChBAO, Satwik Kar, PhD, Vedika Avadhan, MRes, Ryan Thwaites, PhD, Ashley Sanchez Sevilla Uruchurtu, BSc, Tracy J Ruckwardt, PhD, Man Chen, MD, Deepika Nair, MS, Alexandrine Derrien-Colemyn, PhD, Barney S Graham, MD, Malcolm Begg, PhD, Edith Hessel, PhD, Peter Openshaw, ProfFMedSci, Christopher Chiu, ProfPhD
Publikováno v:
The Lancet. Healthy Longevity, Vol 3, Iss 6, Pp e405-e416 (2022)
Summary: Background: Respiratory viral infections are typically more severe in older adults. Older adults are more vulnerable to infection and do not respond effectively to vaccines due to a combination of immunosenescence, so-called inflamm-ageing,
Externí odkaz:
https://doaj.org/article/8d3c14033c20433d979206677c1a5568
Autor:
Ane Ogbe, Barbara Kronsteiner, Donal T. Skelly, Matthew Pace, Anthony Brown, Emily Adland, Kareena Adair, Hossain Delowar Akhter, Mohammad Ali, Serat-E Ali, Adrienn Angyal, M. Azim Ansari, Carolina V. Arancibia-Cárcamo, Helen Brown, Senthil Chinnakannan, Christopher Conlon, Catherine de Lara, Thushan de Silva, Christina Dold, Tao Dong, Timothy Donnison, David Eyre, Amy Flaxman, Helen Fletcher, Joshua Gardner, James T. Grist, Carl-Philipp Hackstein, Kanoot Jaruthamsophon, Katie Jeffery, Teresa Lambe, Lian Lee, Wenqin Li, Nicholas Lim, Philippa C. Matthews, Alexander J. Mentzer, Shona C. Moore, Dean J. Naisbitt, Monday Ogese, Graham Ogg, Peter Openshaw, Munir Pirmohamed, Andrew J. Pollard, Narayan Ramamurthy, Patpong Rongkard, Sarah Rowland-Jones, Oliver Sampson, Gavin Screaton, Alessandro Sette, Lizzie Stafford, Craig Thompson, Paul J. Thomson, Ryan Thwaites, Vinicius Vieira, Daniela Weiskopf, Panagiota Zacharopoulou, Oxford Immunology Network Covid-19 Response T Cell Consortium, Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinical Team, Lance Turtle, Paul Klenerman, Philip Goulder, John Frater, Eleanor Barnes, Susanna Dunachie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Understanding the immune response to SARS-CoV-2 is dependent on being able to distinguish COVID-19 immune responses from cross-reactive immune responses to other coronaviruses. Here the authors show that choice of antigens and whether an ICS, ELISPOT
Externí odkaz:
https://doaj.org/article/316bcccee68f41c8b075256474e98d3e
Autor:
Savino Spadaro, Mirae Park, Cecilia Turrini, Tanushree Tunstall, Ryan Thwaites, Tommaso Mauri, Riccardo Ragazzi, Paolo Ruggeri, Trevor T. Hansel, Gaetano Caramori, Carlo Alberto Volta
Publikováno v:
Journal of Inflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region of 40%. There has been slow but i
Externí odkaz:
https://doaj.org/article/d5508b30b55f4dfd85402c80bcae5107
Autor:
Ryan Thwaites
Publikováno v:
Journal of Leukocyte Biology. 113:351-353
Trans-epithelial migration and physical interaction are required for full activation of neutrophils during in vitro RSV infection.
Autor:
Paul Collini, Charlotte Summers, Graciela Isabel García Dorival, Andrew Ustianowski, Ryan Thwaites, Innocent Gerald Asiimwe, Lance Turtle, Thushan De Silva, Malcolm Gracie Semple, Tom Fletcher, Matthew Siggins, Patrick Lillie, Mark Lyttle, Effrossyni Gkrania-Klotsas, Ahilanandan Dushianthan, Paul Dark, David Price, Antonia Ho, Clark Russell, John Kenneth Baillie
Publikováno v:
Relph, K A, Russell, C D, Fairfield, C J, Turtle, L, De Silva, T, Siggins, M K, Drake, T M, Thwaites, R S, Abrams, S, Moore, S C, Hardwick, H E, Oosthuyzen, W, Harrison, E M, Docherty, A B, Openshaw, P J M, Baillie, J K & Semple, M G & Ho, A 2022, ' Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission ', Open forum infectious diseases, vol. 9, no. 5 . https://doi.org/10.1093/ofid/ofac179
Investigators, I S A R A E I C C C C C ISARICC & Dark, P 2022, ' Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. ', Open Forum Infectious Diseases, vol. 9, no. 5, ofac179 . https://doi.org/10.1093/ofid/ofac179
Investigators, I S A R A E I C C C C C ISARICC & Dark, P 2022, ' Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. ', Open Forum Infectious Diseases, vol. 9, no. 5, ofac179 . https://doi.org/10.1093/ofid/ofac179
Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce07cd41416a4c1baa2b4eefe096672
http://hdl.handle.net/10044/1/96777
http://hdl.handle.net/10044/1/96777
Autor:
Charlotte Summers, Andrew Ustianowski, Sarah McCafferty, Ryan Thwaites, Innocent Gerald Asiimwe, Stuart Hartshorn, Malcolm Gracie Semple, Tom Fletcher, Michael Kenneth Sullivan, Patrick Lillie, Mark Lyttle, Suzannah Lant, Jennifer Susan Lees, Effrossyni Gkrania-Klotsas, Ahilanandan Dushianthan, Paul Dark, David Price, Antonia Ho, Patrick Mark, Shona Moore, John Kenneth Baillie
Publikováno v:
Nephrology Dialysis Transplantation
Investigators, ISARICC & Dark, P 2022, ' Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. ', Nephrology, dialysis, transplantation, vol. 37, no. 2, pp. 271-284 . https://doi.org/10.1093/ndt/gfab303
Sullivan, M K, Lees, J S, Docherty, A B, Oates, G, Hardwick, H E, Russell, C D, Merson, L, Dunning, J, Nguyen-Van-Tam, J S, Openshaw, P, Harrison, E M, Baillie, J K, Investigators, ISARICC, Semple, M G, Ho, A & Mark, P B 2021, ' Acute kidney injury in patients hospitalised with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study ', PLoS Medicine . https://doi.org/10.1093/ndt/gfab303
Investigators, ISARICC & Dark, P 2022, ' Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. ', Nephrology, dialysis, transplantation, vol. 37, no. 2, pp. 271-284 . https://doi.org/10.1093/ndt/gfab303
Sullivan, M K, Lees, J S, Docherty, A B, Oates, G, Hardwick, H E, Russell, C D, Merson, L, Dunning, J, Nguyen-Van-Tam, J S, Openshaw, P, Harrison, E M, Baillie, J K, Investigators, ISARICC, Semple, M G, Ho, A & Mark, P B 2021, ' Acute kidney injury in patients hospitalised with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study ', PLoS Medicine . https://doi.org/10.1093/ndt/gfab303
Background Acute kidney injury (AKI) is common in coronavirus disease 2019 (COVID-19). This study investigated adults hospitalized with COVID-19 and hypothesized that risk factors for AKI would include comorbidities and non-White race. Methods A pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255916e2f3598cc57db18e093ed3b3eb
http://hdl.handle.net/10044/1/94930
http://hdl.handle.net/10044/1/94930
Autor:
Alexander Mentzer, David Brealey, Mahdad Noursadeghi, Charlotte Summers, Graciela Isabel García Dorival, Andrew Ustianowski, Sarah McCafferty, Ryan Thwaites, Ashley Sanchez Sevilla Uruchurtu, Lorna Finch, Innocent Gerald Asiimwe, Charlotte-Eve Short, Lance Turtle, Lauren Lett, Cameron J Fairfield, Malcolm Gracie Semple, Tom Fletcher, Manu Shankar-Hari, Matthew Siggins, Chrysa Koukorava, Patrick Lillie, Suzannah Lant, Louise Sigfrid, Effrossyni Gkrania-Klotsas, Marlies Ostermann, Ahilanandan Dushianthan, Christopher Green, Felicity Liew, Matthew O'Shea, Paul Dark, William Paxton, Clark Russell, Georgios Pollakis, Shona Moore, John Kenneth Baillie
Publikováno v:
Science Immunology
Thwaites, R, Uruchurtu, A S S, Siggins, M K, Liew, F, Russell, C D, Moore, S C, Fairfield, C, Carter, E, Abrams, S, Short, C-E, Thaventhiran, T, Bergstrom, E, Gardener, Z, Ascough, S, Chiu, C, Docherty, A B, Hunt, D, Crow, J J, Solomon, T, Taylor, G P, Turtle, L, Harrison, E M, Dunning, J, Semple, M G, Baillie, J K, Openshaw, P & The ISARIC4C Investigators, 2021, ' Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19 ', Science Immunology . https://doi.org/10.1126/sciimmunol.abg9873
Thwaites, R, Uruchurtu, A S S, Siggins, M K, Liew, F, Russell, C D, Moore, S C, Fairfield, C, Carter, E, Abrams, S, Short, C-E, Thaventhiran, T, Bergstrom, E, Gardener, Z, Ascough, S, Chiu, C, Docherty, A B, Hunt, D, Crow, J J, Solomon, T, Taylor, G P, Turtle, L, Harrison, E M, Dunning, J, Semple, M G, Baillie, J K, Openshaw, P & The ISARIC4C Investigators, 2021, ' Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19 ', Science Immunology . https://doi.org/10.1126/sciimmunol.abg9873
GM-CSF is elevated early, scaled with severity, and is central to the inflammatory response in COVID-19, but not severe influenza.
While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways that driv
While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways that driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4484013bcc4b4a6a6fa6877f6af24e
http://hdl.handle.net/10044/1/86398
http://hdl.handle.net/10044/1/86398
Autor:
Alexander Mentzer, Louisa Pollock, David Brealey, Mahdad Noursadeghi, Charlotte Summers, Graciela Isabel García Dorival, Mark Pritchard, Andrew Ustianowski, Ryan Thwaites, Quen Mok, Innocent Gerald Asiimwe, Stuart Hartshorn, Lance Turtle, Lauren Lett, Shondipon Laha, Malcolm Gracie Semple, Tom Fletcher, Chrysa Koukorava, Patrick Lillie, Ewen Harrison, Suzannah Lant, Louise Sigfrid, Meera Chand, Chloe Donohue, Ahilanandan Dushianthan, Jordan Clark, Christopher Green, Mark Peters, Sarah McDonald, Paul Dark, Luke Hodgson, Emma Thomson, Tamas Leiner, William Paxton, Georgios Pollakis, Shona Moore, Janet Scott, John Kenneth Baillie
Publikováno v:
The BMJ
Swann, OV, Holden, KA, Turtle, L, Pollock, L, Fairfield, CJ, Drake, TM, Seth, S, Egan, C, Hardwick, HE, Halpin, S, Girvan, M, Donohue, C, Pritchard, M, Patel, LB & Investigators, ISARICC 2020, ' Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. ', BMJ (Clinical research ed.) . https://doi.org/10.1136/bmj.m3249
BMJ
Swann, O V, Holden, K A, Turtle, L, Pollock, L, Fairfield, C J, Drake, T M, Seth, S, Egan, C, Hardwick, H E, Halpin, S, Girvan, M, Donohue, C, Pritchard, M, Patel, L B, Ladhani, S, Sigfrid, L, Sinha, I P, Olliaro, P L, Nguyen-Van-Tam, J S, Horby, P W, Merson, L, Carson, G, Dunning, J, Openshaw, P J M, Baillie, J K, Harrison, E M, Docherty, A B & Semple, M G 2020, ' Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom : prospective multicentre observational cohort study ', British Medical Journal (BMJ), vol. 2020, no. 370, m3249 . https://doi.org/10.1136/bmj.m3249
Swann, OV, Holden, KA, Turtle, L, Pollock, L, Fairfield, CJ, Drake, TM, Seth, S, Egan, C, Hardwick, HE, Halpin, S, Girvan, M, Donohue, C, Pritchard, M, Patel, LB & Investigators, ISARICC 2020, ' Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. ', BMJ (Clinical research ed.) . https://doi.org/10.1136/bmj.m3249
BMJ
Swann, O V, Holden, K A, Turtle, L, Pollock, L, Fairfield, C J, Drake, T M, Seth, S, Egan, C, Hardwick, H E, Halpin, S, Girvan, M, Donohue, C, Pritchard, M, Patel, L B, Ladhani, S, Sigfrid, L, Sinha, I P, Olliaro, P L, Nguyen-Van-Tam, J S, Horby, P W, Merson, L, Carson, G, Dunning, J, Openshaw, P J M, Baillie, J K, Harrison, E M, Docherty, A B & Semple, M G 2020, ' Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom : prospective multicentre observational cohort study ', British Medical Journal (BMJ), vol. 2020, no. 370, m3249 . https://doi.org/10.1136/bmj.m3249
Objective To characterise the clinical features of children and young people admitted to hospital with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK and explore factors associated with admission
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42cff7832ab2071ba8b826afac391d7
Autor:
Alexander Mentzer, Mahdad Noursadeghi, Charlotte Summers, Graciela Isabel García Dorival, CESAR LOPEZ-CAMACHO, Gavin Screaton, Andrew Ustianowski, Ryan Thwaites, Lorna Finch, Innocent Gerald Asiimwe, Anna McNaughton, Stuart Hartshorn, Robert Paton, Gary Leeming, Lance Turtle, Thushan De Silva, Lauren Lett, Maria Vittoria Mancini, Chris Davis, Wei Shen Lim, Malcolm Gracie Semple, Tom Fletcher, Katie Ahmed, Jeremy Ratcliff, Chrysa Koukorava, Patrick Lillie, Kreepa Kooblall, Oliver Sampson, Benjamin Small, Craig Thompson, Beibei Wang, Ingeborg Welters, Suzannah Lant, Paul Klenerman, Anil Sharma, Paul Matthew Ridley, Rebecca Jensen, Nigel Temperton, José Lourenço, Effrossyni Gkrania-Klotsas, James Moon, Robyn Kiy, Ahilanandan Dushianthan, Christopher Green, Mark Peters, Sarah McDonald, Paul Dark, Emma Thomson, William Paxton, Ascanio Tridente, Georgios Pollakis, Shona Moore, Dan Hawcutt, John Kenneth Baillie
Publikováno v:
Eurosurveillance
Thompson, CP, Grayson, NE, Paton, RS, Bolton, JS, Lourenço, J, Penman, BS, Lee, LN, Odon, V, Mongkolsapaya, J, Chinnakannan, S, Dejnirattisai, W, Edmans, M, Simmonds, P & Dark, P 2020, ' Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. ', Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, vol. 25, no. 42 . https://doi.org/10.2807/1560-7917.es.2020.25.42.2000685
2020, ' Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020 ', Eurosurveillance, vol. 25, no. 42 . https://doi.org/10.2807/1560-7917.ES.2020.25.42.2000685
Thompson, CP, Grayson, NE, Paton, RS, Bolton, JS, Lourenço, J, Penman, BS, Lee, LN, Odon, V, Mongkolsapaya, J, Chinnakannan, S, Dejnirattisai, W, Edmans, M, Simmonds, P & Dark, P 2020, ' Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. ', Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, vol. 25, no. 42 . https://doi.org/10.2807/1560-7917.es.2020.25.42.2000685
2020, ' Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020 ', Eurosurveillance, vol. 25, no. 42 . https://doi.org/10.2807/1560-7917.ES.2020.25.42.2000685
Background The progression and geographical distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United Kingdom (UK) and elsewhere is unknown because typically only symptomatic individuals are diagnosed. We pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377658e03103d20277d438d247686839
https://kar.kent.ac.uk/83760/1/eurosurv-25-42-6.pdf
https://kar.kent.ac.uk/83760/1/eurosurv-25-42-6.pdf
Autor:
Paul Kellam, Jacques Banchereau, Ryan Thwaites, Ling Pei Ho, Simon Blankley, Malcolm Gracie Semple, Wendy Barclay, Lydia Drumright, Mark Griffiths, Jonathan Nguyen-Van-Tam, Anne O'Garra, David Hume, Jethro Herberg, Peter Simmonds, Paul Aylin, Michael Cox, Tracy Hussell, Sebastian Johnston, John Kenneth Baillie
In the version of this article initially published, a source of funding was not included in the Acknowledgements section. That section should include the following: P.J.M.O. was supported by EU FP7 PREPARE project 602525. The error has been corrected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d72cb1420478a09be1c432869449585
http://hdl.handle.net/10044/1/67593
http://hdl.handle.net/10044/1/67593