Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ryan T. Cirz"'
Autor:
Ivan Laponogov, Xiao-Su Pan, Dennis A. Veselkov, Ryan T. Cirz, Allan Wagman, Heinz E. Moser, L. Mark Fisher, Mark R. Sanderson
Publikováno v:
Open Biology, Vol 6, Iss 9 (2016)
As part of a programme of synthesizing and investigating the biological properties of new fluoroquinolone antibacterials and their targeting of topoisomerase IV from Streptococcus pneumoniae, we have solved the X-ray structure of the complexes of two
Externí odkaz:
https://doaj.org/article/d64ca6b4e8754697892b5dbd71819563
Publikováno v:
Antimicrobial agents and chemotherapy. 66(5)
The World Health Organization (WHO) has warned that our current arsenal of antibiotics is not innovative enough to face impending infectious diseases, especially those caused by multidrug-resistant Gram-negative pathogens. Although the current precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9aa9787bdfe0cbaca0ba30e8217e087
https://pubmed.ncbi.nlm.nih.gov/35471042
https://pubmed.ncbi.nlm.nih.gov/35471042
Autor:
Frederick Cohen, James B. Aggen, Logan D. Andrews, Zahra Assar, Jen Boggs, Taylor Choi, Paola Dozzo, Ashton N. Easterday, Cat M. Haglund, Darin J. Hildebrandt, Melissa C. Holt, Kristin Joly, Adrian Jubb, Zeeshan Kamal, Timothy R. Kane, Andrei W. Konradi, Kevin M. Krause, Martin S. Linsell, Timothy D. Machajewski, Olga Miroshnikova, Heinz E. Moser, Vincent Nieto, Thu Phan, Craig Plato, Alisa W. Serio, Julie Seroogy, Anton Shakhmin, Adam J. Stein, Alex D. Sun, Serguei Sviridov, Zhan Wang, Kenneth Wlasichuk, Wen Yang, Xiaoming Zhou, Hai Zhu, Ryan T. Cirz
Publikováno v:
ChemMedChem. 14:1560-1572
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) is a Zn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a9e4225a28b2cee6c189abdf1bd85c
https://doi.org/10.1002/cmdc.201900287
https://doi.org/10.1002/cmdc.201900287
Publikováno v:
Nucleic Acids Research
Coordinating multiple activities of complex enzymes is critical for life, including transcribing, replicating and repairing DNA. Bacterial RecBCD helicase–nuclease must coordinate DNA unwinding and cutting to repair broken DNA. Starting at a DNA en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e4b4316997e85986ce399c464a2c3b
https://pubmed.ncbi.nlm.nih.gov/32597964
https://pubmed.ncbi.nlm.nih.gov/32597964
Autor:
Ryan T Cirz, Jodie K Chin, David R Andes, Valérie de Crécy-Lagard, William A Craig, Floyd E Romesberg
Publikováno v:
PLoS Biology, Vol 3, Iss 6, p e176 (2005)
The emergence of drug-resistant bacteria poses a serious threat to human health. In the case of several antibiotics, including those of the quinolone and rifamycin classes, bacteria rapidly acquire resistance through mutation of chromosomal genes dur
Externí odkaz:
https://doaj.org/article/9528bccaaca344b591fade312f06350b
Autor:
Kevin M, Krause, Cat M, Haglund, Christy, Hebner, Alisa W, Serio, Grace, Lee, Vincent, Nieto, Frederick, Cohen, Timothy R, Kane, Timothy D, Machajewski, Darrin, Hildebrandt, Chris, Pillar, Mary, Thwaites, Danielle, Hall, Lynn, Miesel, Meredith, Hackel, Amanda, Burek, Logan D, Andrews, Eliana, Armstrong, Lee, Swem, Adrian, Jubb, Ryan T, Cirz
Publikováno v:
Antimicrobial agents and chemotherapy. 63(11)
New drugs with novel mechanisms of resistance are desperately needed to address both community and nosocomial infections due to Gram-negative bacteria. One such potential target is LpxC, an essential enzyme that catalyzes the first committed step of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e018c1e74a4ab5cd3628401115df7b3a
https://pubmed.ncbi.nlm.nih.gov/31451507
https://pubmed.ncbi.nlm.nih.gov/31451507